Oral Insulin Delivery: a Patent Review

Abstract

Insulin, on oral administration, is very troublesome because of its limited bioavailability. The evolution of oral insulin delivery formulations is greatly desired for non-invasive therapy by overcoming its low bioavailability, GIT enzymatic deactivation, poor lipophilicity and low stability. Different approaches have been proposed to boost oral insulin bioavailability in insulin-delivery systems and emerging effective therapies by using nanoparticle formulation, nanocapsid, modified chitosan particles, polydopamine microcapsules, and nanoliposomes. The present review includes patents and patent applications that were published between 2017 and January 2022.

Computational formulation study of insulin on biodegradable polymers

“…13,14 Moreover, researchers are further investigating several methods for increasing the bioavailability of oral insulin, including absorption enhancers, enzyme inhibitors and polymers enteric coatings. 15,16…”

“…13,14 Moreover, researchers are further investigating several methods for increasing the bioavailability of oral insulin, including absorption enhancers, enzyme inhibitors and polymers enteric coatings. 15,16 Polymers derived from natural sources exhibit biocompatibility, biodegradability, and mucoadhesion properties which make them suitable for drug delivery. 17 Apparently, researchers in literature already used nanoparticle carrier adjuvants composed of nontoxic natural polymers along with biologicals are best suited to extreme gastric and thermal conditions like body.…”