Oral Infection and Vascular Disease

Meurman, Jukka H.; Sanz, Mariano; Janket, Sok-Ja

doi:10.2174/1567270000704010032

Cited by 9 publications

(11 citation statements)

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“…[2] As a result of high prevalence of both coronary artery disease (CAD) and periodontal disease it has led to a hypothesis that these might be connected. [3]…”

Section: Introductionmentioning

confidence: 99%

Assessment of the effect of periodontal treatment in patients with coronary artery disease: A pilot survey

Rastogi

Singhal

Sethi

et al. 2012

Journal of Cardiovascular Disease Research

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Background:Periodontitis is a chronic inflammatory condition believed to cause a low but long lasting systemic inflammatory reaction which in turn contributes to the development of atherosclerosis. Recent data suggests that around 40% cases of coronary artery disease remain unaccounted despite the identification of the classical risk factors.Objectives:To evaluate the efficacy of non surgical periodontal therapy on the levels of serum inflammatory markers in subjects with chronic periodontitis and known coronary artery disease.Materials and Methods:Twenty subjects with known coronary artery disease (CAD) were recruited from the Department of Cardiology, CSM Medical University, Lucknow, India, for this study. Periodontal disease was measured through the clinical parameters bleeding on probing (BOP) and probing depth (PD). All subjects received non surgical periodontal therapy that included oral hygiene instructions and meticulous scaling and root planing. Systemic levels of inflammatory markers such as high-sensitivity C reactive proteins (hsCRP), tumor necrosis factor-α (TNF-α), and white blood cell (WBC) counts were measured prior to and 1 month after periodontal therapy.Results:Subjects experienced significant reductions in bleeding on probing (BOP) and probing depth (PD), indicating improvement in overall periodontal health. In all subjects, high-sensitivity C reactive proteins (hsCRP), and WBC counts were reduced significantly,; however, tumor necrosis factor-α (TNF-α) levels showed no statistically significant reduction.Conclusion:In this study, periodontal treatment resulted in a significant decrease in bleeding on probing (BOP) and probing depth (PD), and this treatment lowered the serum inflammatory markers (hsCRP and WBC counts) in patients with coronary artery disease. This may result in a decreased risk for coronary artery disease in the periodontally treated patients.

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“…[2] As a result of high prevalence of both coronary artery disease (CAD) and periodontal disease it has led to a hypothesis that these might be connected. [3]…”

Section: Introductionmentioning

confidence: 99%

Assessment of the effect of periodontal treatment in patients with coronary artery disease: A pilot survey

Rastogi

Singhal

Sethi

et al. 2012

Journal of Cardiovascular Disease Research

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“…Of note, IL-6, together with other pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNFa) and Interleukin-1 (IL-1), can inhibit triglyceride synthesis and, at the same time, can promote insulin resistance in various target tissue, highlighting the complex interplay between metabolic and biochemical inflammatory pathways in CV [ 19 ]. These markers have also been found to be elevated in patients receiving statin therapy, despite their cholesterol levels being well controlled [ 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. This scenario suggests that inflammation may indeed play a significant role in cardiovascular risk, even in patients who are already taking statins [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: The Link Between Inflammation and Cardiovascular Riskmentioning

confidence: 99%

“…These markers have also been found to be elevated in patients receiving statin therapy, despite their cholesterol levels being well controlled [ 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. This scenario suggests that inflammation may indeed play a significant role in cardiovascular risk, even in patients who are already taking statins [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: The Link Between Inflammation and Cardiovascular Riskmentioning

confidence: 99%

“…However, recent studies only proved and emphasized the significance of the role of inflammation in cardiovascular risk [ 9 , 10 , 11 , 12 , 13 , 14 ]. Furthermore, inflammation is a pivotal player not only as a systemic condition but also as a substantial determinant of CV risk in localized settings such as the oral cavity [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Inflammation Beats Cholesterol: A Comment on the Unequivocal Driver of Cardiovascular Disease Risk

Vaccarezza

Galassi

2023

JCM

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Despite advancements in the current standard of care, cardiovascular diseases continue to hold the top spot as the leading cause of mortality worldwide. The development of atherosclerosis is the most common culprit behind ailments such as myocardial infarction, stroke, and peripheral vascular disease. Consequently, it imposes a significant burden on life expectancy, quality of life, morbidity, and societal costs. Both increased cholesterol levels and the activation of the inflammatory cascade are known as cardiovascular risk facts. Their relative weight is in the spotlight of curent biomedical research. Newly published data shed light on the role of inflammation in determining cardiovascular risk irrespective of cholesterol levels and cholesterol-lowering therapies.

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“…It was reported that elderly individuals without dementia were found to have an average of only 2.7 fillings whereas elderly individuals with dementia or Alzheimer's disease averaged 7.8 teeth with fillings (1)(2)(3)(4). A recent authoritative review showed a clear association between cavities, gum health and heart disease (5). Connection between diabetes as well as heart disease and dental decay have been associated for decades (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Dental Patient: Human Being or Only A Set of Teeth ??

Singh¹,

Gupta²,

Bhatia³

et al. 2014

Journal of Oral Health and Community Dentistry

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The practise of dentistry involves working with patients, who come to us with specific dental problem with a blind faith in us. It is very important that we dentists see our patients as human beings first and not just as a set of teeth. It is rightly said, "Mouth is a Mirror of the Health". Many of the oral diseases are also associated with systemic conditions including stress, diabetes, genetic disorders or age related diseases. Care should be also emphasized on the surrounding environment which equally contributes to the health of the patient.The aim of this article is to create awareness on the human aspect of our patients, to look beyond teeth and the things we can do to care for our patients as a whole and also the environment.

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Oral Infection and Vascular Disease

Cited by 9 publications

References 0 publications

Assessment of the effect of periodontal treatment in patients with coronary artery disease: A pilot survey

Assessment of the effect of periodontal treatment in patients with coronary artery disease: A pilot survey

Inflammation Beats Cholesterol: A Comment on the Unequivocal Driver of Cardiovascular Disease Risk

Dental Patient: Human Being or Only A Set of Teeth ??

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