Oral Immunotherapy

Todoric, Krista; Merrill, Sarah

doi:10.1016/j.pop.2022.11.006

Cited by 2 publications

(2 citation statements)

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“…Small studies on multiple-food OIT have suggested a similar safety and efficacy profile [ 6 , 7 ]. The effects of OIT may be dependent on the starting or maintenance dose (or goal), duration, and frequency of dosing as well as patient-specific factors, such as age and food-specific IgE levels [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Review of Shared Decision-Making, Published Protocols, and Post-desensitization Strategies in Oral Immunotherapy (OIT)

Laubach,

Kim,

Greenhawt

et al. 2024

Curr Allergy Asthma Rep

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Purpose of Review The aim of this review is to highlight key published oral immunotherapy (OIT) protocols and post-desensitization strategies for the major food allergens and to cover important concepts to consider when evaluating OIT for food-allergic patients. Shared decision-making should help identify patient and family values which will help influence the type of evidence-based protocol and maintenance strategy to use. Recent Findings With food OIT emerging as a treatment option, there is a pressing need for patients, physicians, and other providers to have a nuanced understanding of the management choices available to them. There are now randomized controlled trials (RCT) of OIT for peanut, egg, milk, and wheat, and reports of cohorts of patients who have undergone OIT for tree nuts and sesame clinically. The current published protocols contain significant diversity in terms of starting dose, build-up schedule, maintenance dose, and even the product used for desensitization. Emerging data can help direct the long-term maintenance strategy for patients on OIT. Summary Based on patient and family values elicited through the shared decision-making process, an OIT protocol may be selected that balances the level of desensitization, potential side effects, frequency of clinic visits, and potential to induce sustained unresponsiveness, among other factors. Once maintenance dosing is reached, most patients will need to maintain regular exposure to the food allergen to remain desensitized. The option to transition to commercial food products with equivalent amounts of food protein as the OIT maintenance dose would simplify the dosing process and perhaps improve palatability as well. Less frequent or decreased OIT dosing can provide practical benefits but may affect the level of desensitization and safety for some patients.

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Section: Introductionmentioning

confidence: 99%

A Review of Shared Decision-Making, Published Protocols, and Post-desensitization Strategies in Oral Immunotherapy (OIT)

Laubach,

Kim,

Greenhawt

et al. 2024

Curr Allergy Asthma Rep

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show abstract

“…As the effects of oral immunotherapy may be influenced by duration, it is kindly suggested to provide additional details elucidating the significance of the 27-day protocol and the newly introduced 15-day protocol. 6 Such clarification would greatly assist readers in comprehending the rationale behind the decisions made during the study.…”

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confidence: 99%