Oral immunotherapy for milk allergy

Yeung, Joanne P; ., .; Alizadehfar, Reza

doi:10.1002/14651858.cd009542

Cited by 48 publications

(65 citation statements)

References 22 publications

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“…[361][362][363] OIT has been studied most extensively and shown to be effective for several food allergens (eg, milk, egg, and peanut) for providing protection against life-threatening reactions during therapy (desensitization) and for the potential of developing tolerance when therapy is discontinued. [364][365][366][367][368][369][370][371][372][373][374] Although promising, OIT is also associated with frequent adverse allergic reactions, and thus it is not ready for widespread clinical use. Diets containing extensively heated (baked) milk and egg might be an alternative approach to OIT in approximately 70% of affected patients if findings of efficacy are maintained with improved safety profiles.…”

Section: Section Vii: Management Of Food Allergy and Food-dependent mentioning

confidence: 99%

Food allergy: A practice parameter update—2014

Bernstein¹,

Blessing-Moore²,

Khan³

et al. 2014

Journal of Allergy and Clinical Immunology

708

564

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Section: Section Vii: Management Of Food Allergy and Food-dependent mentioning

confidence: 99%

Food allergy: A practice parameter update—2014

Bernstein¹,

Blessing-Moore²,

Khan³

et al. 2014

Journal of Allergy and Clinical Immunology

708

564

View full text Add to dashboard Cite

“…A Cochrane meta-analysis of five research trials assessing 196 children with cow's milk allergy determined clinical efficacy of OIT (62 and 27% children receiving OIT could ingest a full and a partial serving of milk, respectively) [102]. Only 8% tolerated a full serving with none tolerating a partial serving in the control group.…”

Section: Current Research Into Novel Routes Of Administration Oralmentioning

confidence: 99%

Current developments for improving efficacy of allergy vaccines

Sandrini

Rolland

O’Hehir

2015

Expert Review of Vaccines

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Allergic diseases are prevalent worldwide. Allergen immunotherapy (AIT) is a current treatment for allergy, leading to modification of the natural course of disease. Mechanisms of efficacy include Treg through release of IL-10 and TGF-β and specific IgG4 blocking antibodies. Subcutaneous and sublingual routes are popular, but uptake is limited by inconvenience and safety concerns. Inclusion criteria limit application to a small proportion of allergic patients. New forms of immunotherapy are being investigated for more efficacious, convenient and safer options with promising advances in recent years. The rationale of reducing vaccine allergenicity to increase safety while improving immunogenicity led to investigation of T-cell epitope-based peptides and recombinant allergen derivatives. Additionally, different routes of administration and adjuvants and adjunct therapies are being explored. This review discusses the current status of AIT and recent advances to improve clinical efficacy, safety and long-term immune tolerance.

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“…Auch mehrere Metaanalysen konnten die Wirksamkeit hinsichtlich einer Desensibilisierung unter OIT verifizieren [8][9][10][11]. In einer Metaanalyse aus dem Jahr 2013 wurde die Wirksamkeit und Sicherheit von OIT und SLIT (sublinguale Immuntherapie) bei verschiedenen Nahrungsmittelallergien untersucht [8].…”

Section: Desensibilisierung Unter Oitunclassified

“…Dabei zeigte sich, dass Patienten unter OIT ein signifikant niedrigeres Risiko aufwiesen, auf das entsprechende Nahrungsmittel unter Provokation zu Studienende zu reagieren als Patienten der Kontrollgruppen (RR 0,19; 95 %-Konfidenzintervall [KI] 0,09-0,37). Auch Metaanalysen zur OIT bei Kuhmilchoder Hühnereiallergie konnten bei einem Großteil der Patienten eine gute Wirksamkeit in Hinblick auf eine Desensibilisierung zeigen [9][10][11]. Jedoch wiesen die Autoren daraufhin hin, dass die Daten auf einer geringen Anzahl randomisierter, kontrollierter Studien mit kleinem Studienkollektiv und stark unterschiedlichen Studiendesigns basieren.…”

Section: Desensibilisierung Unter Oitunclassified

Allergenspezifische Immuntherapie von Nahrungsmittelallergien im Kindesalter. Aktueller Stand und Perspektiven

Trendelenburg

Blümchen

2016

Bundesgesundheitsbl

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During recent years increasing research has been conducted on casual treatment options for food allergy, with focus on oral immunotherapy (OIT) for hen's egg, cow's milk and peanut allergy. Several studies could show that OIT leads to desensitization or an increase of threshold. However, severe adverse events during this treatment are not uncommon. Whether OIT leads to a sustained, 'robust' development of tolerance in patients has not yet been thoroughly investigated. Besides OIT, some studies on sublingual (SLIT) and epicutaneous immunotherapy (EPIT) were performed, aiming to improve the safety profile. Furthermore, there are some pilot studies investigating a combined treatment of SLIT and OIT or a combined use of anti-IgE treatment or probiotic supplementation with OIT. Further placebo-controlled trials with larger sample size are needed in order to develop standardized protocols before immunotherapy may be used as a therapeutic option for food allergy outside of clinical trials.

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Oral immunotherapy for milk allergy

Cited by 48 publications

References 22 publications

Food allergy: A practice parameter update—2014

Food allergy: A practice parameter update—2014

Current developments for improving efficacy of allergy vaccines

Allergenspezifische Immuntherapie von Nahrungsmittelallergien im Kindesalter. Aktueller Stand und Perspektiven

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