Oral immunotherapy for food allergy: Translation from studies to clinical practice?

Pouessel, G.; Lezmi, Guillaume

doi:10.1016/j.waojou.2023.100747

Cited by 15 publications

(16 citation statements)

References 76 publications

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“…While OIT has proven effective in inducing desensitization to numerous food allergens, as stated in the EAACI recommendations for OIT, "only a minority will experience postdiscontinuation effectiveness [9]." Additionally, OIT comes with several drawbacks, such as a gradual timeline, allergen-specific targeting, and frequent adverse events, highlighting the need for improvements [8,[13][14][15][16][17]. Notably, a substantial percentage (43-86%) of FA-afflicted children globally exhibit allergies to multiple foods, making sequential OIT for various allergens burdensome for both patients and families [18][19][20][21].…”

Section: Andandmentioning

confidence: 99%

Role of biologics in severe food allergy

Dinardo,

Cafarotti,

Fierro

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review This review examine the dynamic landscape of food allergy treatment within the context of emerging biologics. Our purpose is to comprehensively evaluate the potential benefits, challenges, and transformative impact associated with the utilization of biologics in comparison to conventional therapeutic modalities. Recent findings This document synthesizes recent scientific investigations to various biologics, such as omalizumab, ligelizumab, dupilumab, and tezepelumab, providing a nuanced understanding of their roles in oral immunotherapy, rapid desensitization, and overall food allergy management. Recent studies and clinical trials highlight the impact of anti-IgE treatment on food allergies, revealing critical findings such as dose-related efficacy, facilitation of rapid desensitization in peanut allergies, and the sustained positive outcomes observed in individuals with multifood allergies. Summary The use of biologics presents a groundbreaking approach in the treatment of food allergies. The multifaceted action of these agents, along with their potential to overcome the challenges associated with traditional therapies, marks a significant advancement. Despite the persisting challenges of economic constraints and the need for further safety studies, biologics offer a promising avenue for improving the quality of life for individuals with food allergies. Ongoing research and collaborative efforts are imperative to fully realize the transformative potential inherent in these emerging therapeutic frontiers.

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Section: Andandmentioning

confidence: 99%

Role of biologics in severe food allergy

Dinardo,

Cafarotti,

Fierro

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Oral immunotherapy (OIT) is being increasingly implemented as a means of inducing food-specific tolerance (or sustained unresponsiveness) in food allergic patients. 152 Many of the studies…”

Section: Iag Nos Is and Manag Ementmentioning

confidence: 99%

“…Formal studies, ideally involving placebo‐controlled trials, will be important to determine the relevance of biologics to AGS management. Oral immunotherapy (OIT) is being increasingly implemented as a means of inducing food‐specific tolerance (or sustained unresponsiveness) in food allergic patients 152 . Many of the studies have been in children, but OIT also shows promise in adults 153 .…”

Section: Diagnosis and Managementmentioning

confidence: 99%

Tick bites, IgE to galactose‐alpha‐1,3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

Wilson,

Erickson,

Levin

et al. 2024

Allergy

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The recent recognition of a syndrome of tick‐acquired mammalian meat allergy has transformed the previously held view that mammalian meat is an uncommon allergen. The syndrome, mediated by IgE antibodies against the oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non‐primate mammals. Thus, fittingly, this allergic disorder is now called the alpha‐gal syndrome (AGS). The syndrome is strikingly regional, reflecting the important role of tick bites in sensitization, and is more common in demographic groups at risk of tick exposure. Reactions in AGS are delayed, often by 2–6 h after ingestion of mammalian meat. In addition to classic allergic symptomatology such as urticaria and anaphylaxis, AGS is increasingly recognized as a cause of isolated gastrointestinal morbidity and alpha‐gal sensitization has also been linked with cardiovascular disease. The unusual link with tick bites may be explained by the fact that allergic cells and mediators are mobilized to the site of tick bites and play a role in resistance against ticks and tick‐borne infections. IgE directed to alpha‐gal is likely an incidental consequence of what is otherwise an adaptive immune strategy for host defense against endo‐ and ectoparasites, including ticks.

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“…While specific and comprehensive data on the global prevalence of food allergies is limited, the World Allergy Organization (WAO) has estimated, based on data from 89 countries, that over 250 billion individuals throughout the globe are already affected by allergy diseases. This prevalence is expected to increase to 4 billion individuals by 2050 [ 200 , 201 , 202 , 203 ]. Food is a crucial source of health and nutrition, yet it is still a mystery why some food items can induce an allergic response in the body, which is the primary focus of research on food allergies.…”

Section: Allergenicity From Egg Proteinsmentioning

confidence: 99%

The Impact of Processing and Extraction Methods on the Allergenicity of Targeted Protein Quantification as Well as Bioactive Peptides Derived from Egg

et al. 2023

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This review article discusses advanced extraction methods to enhance the functionality of egg-derived peptides while reducing their allergenicity. While eggs are considered a nutrient-dense food, some proteins can cause allergic reactions in susceptible individuals. Therefore, various methods have been developed to reduce the allergenicity of egg-derived proteins, such as enzymatic hydrolysis, heat treatment, and glycosylation. In addition to reducing allergenicity, advanced extraction methods can enhance the functionality of egg-derived peptides. Techniques such as membrane separation, chromatography, and electrodialysis can isolate and purify specific egg-derived peptides with desired functional properties, improving their bioactivity. Further, enzymatic hydrolysis can also break down polypeptide sequences and produce bioactive peptides with various health benefits. While liquid chromatography is the most commonly used method to obtain individual proteins for developing novel food products, several challenges are associated with optimizing extraction conditions to maximize functionality and allergenicity reduction. The article also highlights the challenges and future perspectives, including optimizing extraction conditions to maximize functionality and allergenicity reduction. The review concludes by highlighting the potential for future research in this area to improve the safety and efficacy of egg-derived peptides more broadly.

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Oral immunotherapy for food allergy: Translation from studies to clinical practice?

Cited by 15 publications

References 76 publications

Role of biologics in severe food allergy

Role of biologics in severe food allergy

Tick bites, IgE to galactose‐alpha‐1,3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

The Impact of Processing and Extraction Methods on the Allergenicity of Targeted Protein Quantification as Well as Bioactive Peptides Derived from Egg

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