“…In fact, in the available literature (see below), although usually patients have ascertained IgE-mediated CMA, the immunological changes were investigated less in depth than for aeroallergen immunotherapy, the induction protocols were largely variable, and long-term data are few. Moreover, it is still unclear whether oral desensitization is only the first step toward permanent desensitization or it induces only a transient tolerance [20]. On the other hand, in westernized countries and in real life, the continuous or frequent ingestion of foods, such as cow's milk or hen's egg, after the achievement of desensitization is per se easy to do by patients.…”