Oral immunization with recombinant hepatitis E virus antigen displayed on the Lactococcus lactis surface enhances ORF2-specific mucosal and systemic immune responses in mice

Gao, Shandian; Li, Dandan; Liu, Ying; Zha, Enhui; Zhou, Tiezhong; Yue, Xiqing

doi:10.1016/j.intimp.2014.10.032

Cited by 29 publications

(15 citation statements)

References 26 publications

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“…Previous studies have reported that there are alterations in its expression in animal models of bone defects or fractures 31–34 . Changes in the microstructure could cause fluid flow in the bone matrix, which would change the mechanical environment surrounding the osteocytes 11 .…”

Section: Discussionmentioning

confidence: 99%

The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact

Diao

et al. 2017

Sci Rep

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Osseointegration is the key to implant stability and occlusal support. Biomechanical response and remodeling of peri-implant bone occurs under impact loading. Sclerostin participates in bone formation and resorption through Wnt and RANKL pathways. However the mechanism of microdamage and expression of sclerostin in peri-implant bone under impact load is still unclear. In present study, specific impact forces were applied to the implants with favorable osseointegration in rabbits. The microdamage of peri-implant bone and the expression of sclerostin, β-catenin and RANKL during the process of bone damage and remodeling were investigated by micro-CT, histology, immunofluorescence and RT-qPCR analysis. Interface separation and trabecular fracture were found histologically, which were consistent with micro-CT analyses. Throughout remodeling, bone resorption was observed during the first 14 days after impact, and osseointegration and normal trabecular structure were found by 28 d. The expression of sclerostin and RANKL increased after impact and reached a maximum by 14 d, then decreased gradually to normal levels by 28 d. And β-catenin expression was opposite. Results indicated that sclerostin may involve in the peri-implant bone damage caused by impact and remodeling through Wnt/β-catenin and RANKL/RANK pathways. It will provide a new insight in the diagnosis and treatment for patients suffering impact.

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Section: Discussionmentioning

confidence: 99%

The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact

Diao

et al. 2017

Sci Rep

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“…Additionally, other studies reported a dendritic cell maturation effect and cytokine secretion induction [101]. Notwithstanding the hopeful nature of recombinant LABs as vectors for mucosal vaccines and the promising results obtained from murine tests, some characteristics have to be considered, namely that the vaccine strains, although mentioned as GRAS, could not be labelled as avirulent due to the potential transition of antibiotic selection markers into microbes [102]. The advancement of LAB based vaccines requires considereation of various aspects like the role or location of each antigen expressed and route of administration (as different routes will have different immune effects).…”

Section: Lactic Acid Bacteria-based Vaccinesmentioning

confidence: 99%

Edible Vaccines: Promises and Challenges

Kurup

Thomas

2019

Mol Biotechnol

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Vaccines are biological preparations that improve immunity to particular diseases and form an important innovation of 19th century research. It contains a protein that resembles a disease-causing microorganism and is often made from weak or killed forms of the microbe. Vaccines are agents that stimulate the body's immune system to recognize the antigen. Now, a new form of vaccine was introduced which will have the power to mask the risk side of conventional vaccines. This type of vaccine was produced from plants which are genetically modified. In the production of edible vaccines, the gene-encoding bacterial or viral disease-causing agent can be incorporated in plants without losing its immunogenic property. The main mechanism of action of edible vaccines is to activate the systemic and mucosal immunity responses against a foreign diseasecausing organism. Edible vaccines can be produced by incorporating transgene in to the selected plant cell. At present edible vaccine are developed for veterinary and human use. But the main challenge faced by edible vaccine is its acceptance by the population so that it is necessary to make aware the society about its use and benefits. When compared to other traditional vaccines, edible vaccines are cost effective, efficient and safe. It promises a better prevention option from diseases.

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“…The Open Reading Frame (ORF) 2 encodes the capsid protein against which all neutralizing antibodies are targeted ( Figure 6 ). Therefore all of the efforts to develop a safe and effective vaccine have focused on ORF2 [ 72 ]. Vaccine antigens have been cloned in insects, yeast, baculovirus, etc.…”

Section: Hepatitis E Virusmentioning

confidence: 99%

Hepatitis Vaccines

Ogholikhan

Schwarz

2016

Vaccines

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Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B globally. Given the lack of a hepatitis C vaccine, the many challenges facing the production of a hepatitis C vaccine will be shown, along with current and former vaccination trials. As there is no current FDA-approved hepatitis E vaccine, we will present vaccination data that is available in the rest of the world. Finally, we will discuss the existing challenges and questions facing future endeavors for each of the hepatitis viruses, with efforts continuing to focus on dramatically reducing the morbidity and mortality associated with these serious infections of the liver.

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Oral immunization with recombinant hepatitis E virus antigen displayed on the Lactococcus lactis surface enhances ORF2-specific mucosal and systemic immune responses in mice

Cited by 29 publications

References 26 publications

The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact

The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact

Edible Vaccines: Promises and Challenges

Hepatitis Vaccines

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