Oral Immunization of Mice with Metabolic Antigens of Trichinella spiralis Larvae: Effects on the Kinetics of Intestinal Cell Response including Mast Cells and Polymorphonuclear Eosinophils

Tronchin, G.; DuToit, Ernette D; Vernes, A; Biguet, J.

doi:10.2307/3280345

Cited by 17 publications

(8 citation statements)

References 4 publications

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“…Similar observations have been made in infections of guinea pigs with Trichostrongylus colubriformis [25], and in rats [14] and mice [31] infected with T. spiralis . After challenge in fection with S. ratti, eosinophil infiltration occurred more quickly and in greater degree.…”

Section: Discussionsupporting

confidence: 68%

“…Re cent studies, however, have not supported the concept that mucosal mast cells are integral to the expulsion of worms. There was no change in the expulsion of N. brasiliensis in mast-cell-deficient mice [3,31], nor were there any significant differences in mast cell counts in a number of strains of mice with varying ca pacities to expel Trichuris mûris [15]. Nevertheless, there must be reasons for the increases in the numbers of lamina propria mast cells and globule leucocytes in worm infections.…”

Section: Discussionmentioning

confidence: 99%

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Kinetics of Intestinal Lamina propria Mast Cells, Globule Leucocytes, Intraepithelial Lymphocytes, Goblet Cells and Eosinophils in Murine Strongyloidiasis

Carroll

Mayrhofer

Dawkins

et al. 1984

Int Arch Allergy Immunol

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The changes in numbers of 6 cell populations in the intestine of mice at various intervals after primary and challenge infections with Strongyloides ratti have been quantified. The number of lamina propria mast cells increased 8 days after primary infection and reached a peak at 12 days. After secondary infection, there was a transient fall in mast cell numbers followed by a slow increase. Globule leucocytes showed a similar trend early in the primary infection and had reached normal levels after 28 days. After challenge infection, there was an early and rapid increase in their numbers. Granular intraepithelial lymphocytes did not alter significantly during the first 14 days, but were significantly greater 28 days after primary infection; they did not vary significantly after challenge infection. However, numbers of non-granular intraepithelial lymphocytes increased 10 days after infection, were elevated prior to the secondary infection at 28 days, then declined in numbers nearly 2 weeks after challenge infection. Goblet cells increased significantly 12 days after primary infection then declined rapidly. After challenge infection, there was an accelerated increase in numbers. Eosinophil numbers increased 4 days after infection, reached a peak at 12 days and then declined. After challenge infection, there was an augmented and accelerated increase in eosinophil numbers followed by rapid decline. The role of the various cells types in host defences against worms or in containment of the inflammatory responses evoked by these parasites are discussed.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Kinetics of Intestinal Lamina propria Mast Cells, Globule Leucocytes, Intraepithelial Lymphocytes, Goblet Cells and Eosinophils in Murine Strongyloidiasis

Carroll

Mayrhofer

Dawkins

et al. 1984

Int Arch Allergy Immunol

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“…These findings are in aeeordanee with earlier studies stating that eosinophil granuloeytes in intestinal traet are loeated mainly in lamina propria (3,5,21). Also, the inerease of the numbers of eosinophil granuloeytes in jejunum of parasitized do gs eonfirms the previous findings about response to parasitic agents of intestinal mueosa (14,16,34,41,42).…”

Section: Di̇scussi̇onsupporting

confidence: 76%

“…Experiments in the mıce (7,11,14,41,46), rats (24, 25, 27, 29, 39), guinea pigs (16), turkeys (8), sheep (19) and human (9) have shown that infeetions with helmints and protozoan parasites are assoeiated with pronouneed intestinal mastoeytosis, eosinophilia, plasmaeytosis and increased antibody produetion.…”

Section: Di̇scussi̇onmentioning

confidence: 99%

Eosinophil Granulocytes and Plasma Cells in Jejunal Mucosa of Dogs Naturally Infected With or Without Intestinal Parasites

Ülker;SANDIKÇI¹

2000

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…In mast-cell-deficient W/Wv mice, expulsion of T. spiralis [3] and N. brasiliensis [7] are described to be delayed although in these studies worms were ultimately expelled. Uber et al [35] found no delay of N. brasiliensis expulsion in W/Wv mice, and reconstitution of M MC responses by transplanta tion of bone marrow from congenic + /+ mice did not accelerate worm expulsion [6], In several other murine strains [34] MMC responses do not corre spond with worm expulsion. Similar results were ob tained with our experiments.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Serotonin in Intestinal Mastocytopoiesis and Inflammation during a <i>Trichinella spiralis </i>Infection in Mice

Parmentier¹,

Vries

Ruitenberg

et al. 1987

Int Arch Allergy Immunol

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The involvement of serotonin in the regulation of intestinal mastocytopoiesis and inflammation has been investigated in mice infected with Trichinella spiralis. Two serotonin antagonists, methysergide and ketanserin, were examined for their ability to interfere with jejunal pathology comprising the influx of mucosal mast cells and other inflammatory cells during an infection with T. spiralis and with worm expulsion. In vitro analysis of the frequence of mast cell precursors in bone marrow, blood, spleen and intestinal tissue suggested that the mucosal mast cell response during a T. spiralis infection is probably due to invasion and local maturation in the gut of mast cell precursors, and may be mediated by T-cell-derived mast cell growth factors. Since both serotonin antagonists inhibited the mucosal mast cell response in T. spiralis-infected mice and diminished the influx of eosinophilic granulocytes, goblet cell hyperplasia, and villous atrophy, it was concluded that during a T. spiralis infection in mice release of serotonin may provide an environment that facilitates the local influx in the gut of inflammatory cells. Since worm expulsion was not affected by the serotonin antagonists, these results suggest that worm expulsion can occur without a mast cell and or eosinophilic granulocyte influx. The role of serotonin release by as yet unidentified serotonin-containing cells in the gut in relation with T cell regulation is discussed.

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Oral Immunization of Mice with Metabolic Antigens of Trichinella spiralis Larvae: Effects on the Kinetics of Intestinal Cell Response including Mast Cells and Polymorphonuclear Eosinophils

Cited by 17 publications

References 4 publications

Kinetics of Intestinal Lamina propria Mast Cells, Globule Leucocytes, Intraepithelial Lymphocytes, Goblet Cells and Eosinophils in Murine Strongyloidiasis

Kinetics of Intestinal Lamina propria Mast Cells, Globule Leucocytes, Intraepithelial Lymphocytes, Goblet Cells and Eosinophils in Murine Strongyloidiasis

Eosinophil Granulocytes and Plasma Cells in Jejunal Mucosa of Dogs Naturally Infected With or Without Intestinal Parasites

Involvement of Serotonin in Intestinal Mastocytopoiesis and Inflammation during a <i>Trichinella spiralis </i>Infection in Mice

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