Oral imazalil exposure induces gut microbiota dysbiosis and colonic inflammation in mice

Jin, Cuiyuan; Zeng, Zhaoyang; Fu, Zhengwei; Jin, Yuanxiang

doi:10.1016/j.chemosphere.2016.06.105

Cited by 106 publications

(56 citation statements)

References 58 publications

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“…The problems of IMZ toxicity and side effects observed in previous studies mainly result from its harmful influence on reproduction, neurobehavior, and acute hepatotoxin . In a previous study, we reported that acute exposure to high doses of IMZ (25, 50, and 100 mg/kg/day) induced gut microbiota dysbiosis and colonic inflammation in male ICR mice . More recently, we also observed that IMZ exposure not only resulted in microbiota dysbiosis in the gut, but also induced hepatic metabolism disorder in adult zebrafish .…”

Section: Discussionmentioning

confidence: 67%

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Jin

Luo

et al. 2018

Environmental Toxicology

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Imazalil (IMZ), which is a widely used fungicide, can accumulate in the body and threaten an animal's health. However, this fungicide has adverse effects on aquatic organisms and ultimately affects human health when it leaches into the environment. Our research tried to determine that if IMZ might cause liver damage and its potential to cause-related diseases. In this study, male adult C57BL/6 mice were exposed to 0.1, 0.5, or 2.5 mg/kg body weight IMZ in drinking water for 15 weeks. Then, we evaluated the liver damage at the physiological, biochemical, and transcriptome levels in mice after chronic IMZ exposure. We observed serious ballooning degeneration of hepatocytes in the IMZ-treated groups. And IMZ induced oxidative stress and caused the disorders of bile acid metabolism in mice. In addition, the transcriptome data showed that IMZ has substantial influence on several pathways, including metabolic pathways for drug metabolism, RNA transport, and bile secretion. We further confirmed that the mRNA expression of the key genes involved in oxidative stress and bile acid metabolism were changed of mice exposed to IMZ. Our data suggested that chronic IMZ exposure could induce hepatotoxicity in mice at the physiological, biochemical, and transcriptome levels.

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Section: Discussionmentioning

confidence: 67%

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Jin

Luo

et al. 2018

Environmental Toxicology

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“…In addition, LA‐fed female mice had more Enterococcus faecalis , which was reported to attenuate pro‐inflammatory cytokine secretions through JNK and p38 signaling pathways. Moreover, decreased abundance of Desulfovibrio , which converted sulfate to sulfide, and less abundant Mucispirillum schaedleri may also contribute to relieved inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…However, LA treatment enhanced the growth of pro-inflammatory species Lactobacillus in male mice. For LA-receiving female mice, we found reduced growth of proinflammatory species Mucispirillum schaedleri, Clostridium XIVa and Desulfovibrio, [28] and enhanced growth of anti-inflammatory species Enterococcus faecalis. [29] Taken together, both ALA and LA exert a sex-dependent effect on gut microbiota composition in DIO mice.…”

Section: Ala and La Sex-dependently Alter Gut Microbiota Compositionmentioning

confidence: 98%

Essential Fatty Acids Linoleic Acid and α‐Linolenic Acid Sex‐Dependently Regulate Glucose Homeostasis in Obesity

Zhuang

Shou

Wang

et al. 2018

Molecular Nutrition Food Res

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“…Oxidative stress is tightly associated with hepatic toxicity and is often caused by environmental heavy metals. Metal‐induced alterations in antioxidant enzyme activities have been extensively studied . Pb has been found to derail the antioxidant defense system by interfering with the metals that are essential for antioxidant enzyme activities, supporting the role of oxidative stress in lead hepatotoxicity .…”

Section: Discussionmentioning

confidence: 99%

Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

Luo

Shen

Zhou

et al. 2019

Environmental Toxicology

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Lead (Pb), a non-essential heavy metal, is a major global environmental contaminant with serious toxicological consequences. In the present study, the effects on hepatotoxicity of mice with chronic exposure to low doses of Pb were evaluated. While oral exposure to 0.03 or 0.1 mg/L Pb for 15 weeks in male adult mice had no significant effect on body weights, Pb exposure resulted in liver histopathological effects and increase of hepatic activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). In addition, hepatic reactive oxygen species (ROS) and malondialdehyde (MDA) significantly accumulated after treatment. Conversely, glutathione (GSH) decreased significantly in both 0.03 and 0.1 mg/L Pb-treated groups. Moreover, the hepatic activities of superoxide dismutase 1 (SOD) and catalase (CAT) increased significantly following treatment with 0.1 mg/L Pb for 15 weeks, concomitant with increases in transcriptions of hepatic Sod, Cat, and Gpx. Furthermore, transcriptions of hepatic metallothionein (MT), zinc transporter 5 (Znt5) and copper transporter 1 (Ctr1), and subsequent protein levels were also increased in liver of mice when exposed to 0.1 mg/L Pb for 15 weeks. In addition, the transcriptome data showed that Pb has substantial influence on several pathways, including PPAR signaling pathways, AMPK signaling pathways, fatty acid metabolism, and drug metabolism. Our data suggested that chronic Pb exposure could induce hepatotoxicity at the physiological, biochemical, and transcriptomic levels in mice. K E Y W O R D Shepatotoxicity, oxidative stress, gene expression, Pb

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Oral imazalil exposure induces gut microbiota dysbiosis and colonic inflammation in mice

Cited by 106 publications

References 58 publications

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels

Essential Fatty Acids Linoleic Acid and α‐Linolenic Acid Sex‐Dependently Regulate Glucose Homeostasis in Obesity

Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice

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