2019
DOI: 10.1097/md.0000000000016689
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Oral ibuprofen is superior to oral paracetamol for patent ductus arteriosus in very low and extremely low birth weight infants

Abstract: Paracetamol (acetaminophen) has been proposed as an alternative medication for closing hemodynamically significant patent ductus arteriosus (PDA). However, the clinical outcomes remain inconclusive in very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. The aim of this study was to compare the efficacy and safety of oral paracetamol and ibuprofen for pharmacological closure of PDA in premature infants from a real-world study. This retrospective study enrolled 255 pr… Show more

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Cited by 12 publications
(28 citation statements)
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“…There were a total of 1547 subjects from 10 studies. 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 The studies enrolled neonates ≤28 weeks (1 study), ≤30 weeks (2 studies), ≤32 weeks (2 studies), ≤34 weeks (2 studies), and ≤37 weeks (3 studies) of gestational age. Birthweights varied across studies.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…There were a total of 1547 subjects from 10 studies. 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 The studies enrolled neonates ≤28 weeks (1 study), ≤30 weeks (2 studies), ≤32 weeks (2 studies), ≤34 weeks (2 studies), and ≤37 weeks (3 studies) of gestational age. Birthweights varied across studies.…”
Section: Resultsmentioning
confidence: 99%
“…Lu et al also investigates high dose oral ibuprofen (10 mg/kg/day oral ibuprofen for 3 days), the high dose ibuprofen was shown to have a higher rate of ductal closure compared to standard dose ibuprofen and paracetamol. 13 High dose ibuprofen was shown to be associated with an increase in bilirubin, however, it was reported to have little clinical significance. Bagheri et al study 17 also reported the use of high dose ibuprofen (an initial dose of 20 mg/kg, followed by 10 mg/kg at 24 and 48 h), the study used a higher initial dose compared to Lu et al study.…”
Section: Discussionmentioning
confidence: 99%
“…Estudos anteriores compararam a eficácia e a segurança das formas orais dos medicamentos para o tratamento de hsPCA. 1,2,[10][11][12][13] Além disso, existem poucos estudos sobre as formas IV. Um estudo de Roofthooft et al 14 relatou que o tratamento com paracetamol IV não é eficaz para fechamento de PCA em bebês com MBPN após falha do tratamento com ibuprofeno IV.…”
Section: Discussionunclassified
“…9 Em estudos anteriores, que compararam a eficácia da terapia com paracetamol e ibuprofeno para hsPCA, foram utilizadas formas orais. 1,2,[10][11][12][13][14][15] Com base nesses estudos, uma metanálise recentemente publicada na Cochrane afirma que são necessários estudos antes de qualquer sugestão de uso rotineiro do paracetamol no tratamento da PCA em recémnascidos. Combinando-se os resultados dos estudos incluídos, a taxa de sucesso do paracetamol para fechar uma PCA foi maior do que a do placebo e semelhante à do ibuprofeno e indometacina.…”
Section: Introductionunclassified
“…All preterm infants received echocardiography within 5 days after birth or when clinically indicated. Infants with hsPDA received oral ibuprofen (Shanghai Johnson Pharmaceutical Co., Ltd R Specification: 15 ml: 0.6 g) at a daily dose of 10 mg/(kg•day) for 3 consecutive days (4,15). Successful PDA closure was defined as the absence of PDA shunt confirmed by echocardiography 24-72 h after the treatment.…”
Section: Patients and Data Collectionmentioning
confidence: 99%