Oral IBGard™ Before Colonoscopy: A Single-Center Double-Blinded, Randomized, Placebo-Controlled Trial

Han, James Y.; Moosvi, Zain; Duh, Erica; Park, Sunhee; Albers, Gregory; Samarasena, Jason; Karnes, William E.

doi:10.1007/s10620-020-06383-3

Cited by 1 publication

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies [17,22,25] have proposed that the administration of antispasmodic agents may ease colonic spasms, primarily by inhibiting smooth muscle and relaxing the colon wall. Common antispasmodic agents [25–27] that are currently used include glucagon, peppermint oil, scopolamine, and butyl bromide; however, these antispasmodics have various adverse effects, such as nausea, vomiting, delayed hypoglycaemia, cardiovascular events, and allergic reactions [8,17,28,29]. Therefore, the use of these drugs is limited, particularly for older adults or patients with comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Intestinal topical lidocaine spray improves the efficacy and safety of endoscopic sigmoid polypectomy

Lü¹,

Xiong²,

Wang

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

Background and aims Endoscopic polypectomy can prevent colorectal cancer. Adequate surgical field visualization is crucial to complete resection. To prevent visual field loss caused by intestinal peristalsis, we investigated the efficacy and safety of topical lidocaine spraying during the endoscopic sigmoid polypectomy (ESP). Methods Retrospective analysis was performed on 100 ESP patients admitted from July 2021 to October 2021, among which 50 patients received lidocaine (case group) and other 50 patients received normal saline (control group). Lidocaine or saline was sprayed on the colonic mucosa within 5 cm above and below the polyps before polypectomy. The en-bloc resection rate (EBRR) and complete resection rate (CRR) were primarily evaluated. Secondary outcomes included EBRR for polyps located in the 5–11 o’clock position, sigmoid colon peristalsis frequency, degree of exposure to the surgical field, operative times, and adverse events. Results There were no significant differences in the basic demographic characteristics between the two groups. EBRR and CRR in the case group were 72.9% and 95.8%, and in the control group were 53.3% and 91.1%, respectively. The EBRR of sigmoid polyps located at the 5–11 o’clock positions was significantly higher in the case group (82.8%) than in the control group (56.7%) (P = 0.03). Sigmoid colonic peristalsis was significantly inhibited after lidocaine spraying (P < 0.01). There was no statistical difference in the operative times and adverse event rates between the two groups. Conclusion Topical spraying lidocaine around polyps can safely and effectively reduce intestinal peristalsis, thus improving the EBRR of sigmoid polypectomy.

show abstract