Oral hyposensitization in <i>Parthenium</i> dermatitis

Srinivas, CR; Krupashankar, D S; Kk, Singh; Balachandran, C; Shenoi, Shrutakirthi D

doi:10.1111/j.1600-0536.1988.tb02814.x

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…Parthenium dermatitis occurs in both rural and urban populations. Due to the fact that the eczema, which is difficult to treat and does not disappear spontaneously, can heal without treatment, if the patient merely moves to an area where the plant is not found, it would appear that direct and indirect plant contact are of considerably more importance than pollen (8,18,24,31). This is supported by the very high degree of sensitization (>50%) in the male workers employed in the manual removal of Parthenium (29).…”

Section: Airborne Allergensmentioning

confidence: 99%

Compositae dermatitis: a survey

Paulsen

1992

Contact Dermatitis

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Compositae dermatitis in an allergic contact dermatitis, frequently chronic, triggered by plants of the Compositae family. The condition, which is seen, in particular, in middle-aged and elderly persons, typically starts in the summer months with an acute eczema either corresponding to areas exposed to light and air, or corresponding to areas of plant contact; it disappears spontaneously during the fall of the year. Repeated exposure over a number of years may cause severe intractable dermatitis affecting the patient throughout the year. The responsible allergens are sesquiterpene lactones, and investigations to date indicate that the frequency of the allergy is similar to that seen with some of the contact allergens of the standard patch test series. The diagnosis, however, is difficult, partly due to the fact that the clinical picture may be mistaken for a photodermatosis, and partly owing to the difficulty in obtaining commercially available allergens for patch testing. The diagnosis is therefore based on testing with plant extracts, which can cause pronounced local reactions and possibly active sensitization. A survey is given of the possible modes of sensitization, sex and age distribution, the relationship to photosensitivity and atopy, as well as the possible treatment. It is conclude~, on the basis of the chronic nature of the disease, and the diagnostic and treatment problems, that continued intensive research into the condition is urgently needed.

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Section: Airborne Allergensmentioning

confidence: 99%

Compositae dermatitis: a survey

Paulsen

1992

Contact Dermatitis

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“…In the only case report of its kind, Srinivas et al (20) tried oral hyposensitization in a patient with parthenium dermatitis using crushed leaves. The patient’s symptoms, however, recurred on discontinuation of therapy.…”

Section: Discussionmentioning

confidence: 99%

Oral hyposensitization in patients with contact dermatitis from Parthenium hysterophorus

Handa¹,

Sahoo²,

Sharma³

2001

Contact Dermatitis

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Parthenium hysterophorus is the commonest cause of airborne contact dermatitis in northern India. Treatment is mostly palliative and consists of repeated courses of antihistamines and topical and/or systemic corticosteroids. We have evaluated the effect of oral hyposensitization as an alternative therapeutic modality. In 70% of those patients who completed the study, there was a gradual improvement in their clinical status, as evident from a fall in their clinical severity score for eczema. 30% of patients had an exacerbation during the course of the study and hence hyposensitization in them was stopped. Patients tolerated therapy well and no significant side-effects were seen, except for abdominal pain, 'heartburn' and cheilitis.

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“…future science group Immunotherapy of allergic contact dermatitis Review Pariser et al An uncontrolled, open trial in one person [103] Srinivas et al An uncontrolled, open trial in one person [104] Handa et al [49]. The first report claiming a successful desensitization in 11 out of 12 patients with Rhus dermatitis achieved by intramuscular injections of 'homologous vegetable toxins' was published by Strickler in 1918 [71].…”

Section: Clinical Trials Of Immunotherapy With Haptensmentioning

confidence: 98%

Immunotherapy of Allergic Contact Dermatitis

Śpiewak

2011

Immunotherapy

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The term 'immunotherapy' refers to treating diseases by inducing, enhancing or suppressing immune responses. As allergy is an excessive, detrimental immune reaction to otherwise harmless environmental substances, immunotherapy of allergic disease is aimed at the induction of tolerance toward sensitizing antigens. This article focuses on the historical developments, present state and future outlook for immunotherapy with haptens as a therapeutic modality for allergic contact dermatitis. Inspired by the effectiveness of immunotherapy in respiratory allergies, attempts were undertaken at curing allergic contact dermatitis by means of controlled administration of the sensitizing haptens. Animal and human experiments confirmed that tolerance to haptens can be induced most effectively when the induction of tolerance precedes attempted sensitization. In real life, however, therapy is sought by people who are already sensitized and an effective reversal of hypersensitivity seems more difficult to achieve. Decades of research on Rhus hypersensitivity led to a conclusion that immunotherapy can suppress Rhus dermatitis, however, only to a limited degree, for a short period of time, and at a high risk of side effects, which makes this method therapeutically unprofitable. Methodological problems with most available studies of immunotherapy of contact allergy to nickel make any definite conclusions impossible at this stage.

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Oral hyposensitization in Parthenium dermatitis

Cited by 15 publications

References 6 publications

Compositae dermatitis: a survey

Compositae dermatitis: a survey

Oral hyposensitization in patients with contact dermatitis from Parthenium hysterophorus

Immunotherapy of Allergic Contact Dermatitis

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