Oral Hydration in Rotavirus Diarrhœa: A Double Blind Comparison of Sucrose With Glucose Electrolyte Solution

Sack, DavidA.; Eusof, A; Merson, M H; Black, R. C.; Chowdhury, AzadM.A.K.; Ali, Mohammad; Islam, Soriful; Brown, K. H.

doi:10.1016/s0140-6736(78)91687-2

Cited by 149 publications

(35 citation statements)

References 14 publications

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“…Parents from intravenous rehydration group were given choice of holding room or inpatient intravenous therapy. than five days prior to the emergency room visit; (4) there was no history of antibiotic usage, either within one week before enter¬ ing the study or during the study period; (5) there were no chronic diseases present; and (6) they were dehydrated, based on clinical criteria (see below). Infants who required intensive care or who were significantly hypernatremic-defined as having a serum sodium concentration greater than 160 mEq/L-were excluded from the study.…”

Section: Patients and Methods Patient Selectionmentioning

confidence: 99%

Outpatient Oral Rehydration in the United States

Listernick¹,

Zieserl²,

Davis

1986

Arch Pediatr Adolesc Med

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Section: Patients and Methods Patient Selectionmentioning

confidence: 99%

Outpatient Oral Rehydration in the United States

Listernick¹,

Zieserl²,

Davis

1986

Arch Pediatr Adolesc Med

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“…This solution was originally evaluated in adults with cholera or cholera-like (toxigenic) diarrhoea, the category of patients for whom it was primarily designed. Later, however, its use was extended to children with non-toxigenic diarrhoea, including rotavirus gastroenteritis 25. In the underdeveloped world, diarrhoeal disease is often associated with large stool sodium losses 24.…”

Section: Fluid Managementmentioning

confidence: 99%

Guidelines for managing acute gastroenteritis based on a systematic review of published research

Murphy¹

1998

Archives of Disease in Childhood

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This paper is intended to provide evidencebased recommendations about the assessment and clinical management of infants and children with acute gastroenteritis. These guidelines were derived from a systematic review of published research. The diagnosis of gastroenteritis is not addressed; this is often presumptive and is based on a history of acute diarrhoea in the absence of other likely explanations. Microbiological investigation is not necessary in every case, but may be important in patients who require admission to hospital, in those who have bloody or mucoid diarrhoea suggesting colitis, in high risk patients such as those with an immune deficiency, and in cases where there is diagnostic uncertainty. Clinicians should apply general medical knowledge and clinical judgment in using these guidelines. Scope of guidelinesThe topics addressed are: assessment of the risk of dehydration; assessment of the degree of dehydration; oral rehydration therapy (ORT); strategies for rehydration and maintenance of hydration; management of hypernatraemic dehydration; nutritional management during and after the illness; and the role of pharmacological agents including antidiarrhoeals and antimicrobials. Systematic review: search strategy and evaluation of the evidenceThe search was performed using the MEDLINE and Cinahl databases, and covered the years 1966-97. Some relevant articles were also identified from the references cited in publications identified from these databases. The search was limited to studies of human subjects published in English. Subject headings employed were: "gastroenteritis", "diarrhoea", "rehydration solutions", "dehydration", and "hypernatraemia". Textword searches were also done using the terms "infectious diarrh$", "oral rehydration solution$", and "hypernatr$ dehydration". For each topic the terms "review", "metaanalysis", "randomised controlled trial", "cohort study", and "case control study" were applied. The Cochrane Library database of systematic reviews was searched under subject headings. Evidence from the medical literature and the strength of the recommendations given were then categorised according to a previously described scheme (table 1).

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“…The result indicated that treatment with QWBZP could promote the absorption of sodium and glucose. The mechanism of ORS on rehydration was based on glucose-facilitated sodium transport [46] , while the mechanism of QWBZP on treating rotavirus diarrhea would be more complex and involved in improving the digestive and absorptive function, protecting intestinal mucosa cells from damage induced by rotavirus, and clearance of rotavirus.…”

Section: Discussionmentioning

confidence: 99%

Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder

He¹,

He²,

Wu³

et al. 2001

WJG

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AIM To observe the effects of Qiwei Baizhu Powder (QWBZP) on rotaviral gastroenteritis in children and in animal models.METHODS Enrolled patients were divided into two groups, and one group was treated with oral rehydration solution (ORS) and the other treat ed with oral liquid of QWBZP. Neonate mice were orally infected with 50 µ µ µ µ µL rotavirus suspension (4×10 8 PFU/mL) and treated with ORS or oral liquid of QWBZP, respectively.RESULTS Eighty-three cases of rotaviral gastroenteritis treated with QWBZP revealed a better efficacy than that treated with ORS (χ χ χ χ χ 2 = 10.87, P<0.05). The contents of sodium and glucose as well as number of patients with positive human rotavirus antigen in stool in QWBZP group were all less than that in ORS group. In a nimal models, QWBZP was found effective in treating rotavirus gastroenteritis in neonate NIH mice, as compared with control groups. In QWBZP group, the mortality of infected mice was decreased by 73.3%, the body weight of infected mice was increased, the contents of sodium and glucose as well as number of mice with positive rotavirus antigen in feces were significantly reduced, and the pathological changes such as damage of small intestinal mucosa and villi were also obviously alleviated.CONCLUSION QWBZP has effects on improving the absorptive function of small intestine, shortening the duration of diarrhea and rotavirus shedding from stool and alleviating the pathological changes of small intestine induced by rotavirus.Subject headings gastroenteritis/drug therapy; rotavirus infections/drug therapy; Qiwei baizhu powder/therapeutic use; disease models, animal

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Oral Hydration in Rotavirus Diarrhœa: A Double Blind Comparison of Sucrose With Glucose Electrolyte Solution

Cited by 149 publications

References 14 publications

Outpatient Oral Rehydration in the United States

Outpatient Oral Rehydration in the United States

Guidelines for managing acute gastroenteritis based on a systematic review of published research

Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder

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