Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases

Abstract

This meta-analysis aimed to compare Marfan syndrome (MFS) patients with non-MFS populations based on orofacial health status to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, for articles published between 1 January 2000 and 17 February 2022. PRISMA guidelines were followed to carry out this systematic review. We used the PECO system to classify people with MFS based on whether or not they had distinctive oral health characteristics compared to the non-MFS population. The following are some examples of how PECO is used: P denotes someone who has MFS; E stands for a medical or genetic assessment of MFS; C stands for people who do not have MFS; and O stands for the orofacial characteristics of MFS. Using the Newcastle–Ottawa Quality Assessment Scale, independent reviewers assessed the articles’ methodological quality and extracted data. Four case-control studies were analyzed for meta-analysis. Due to the wide range of variability, we were only able to include data from at least three previous studies. There was a statistically significant difference in bleeding on probing and pocket depth between MFS and non-MFS subjects. MFS patients are more prone to periodontal tissue inflammation due to the activity of FBN1 and MMPs. Early orthodontic treatment is beneficial for the correction of a narrow upper jaw and a high palate, as well as a skeletal class II with retrognathism of the lower jaw and crowding of teeth.

Association between Pre-Pregnancy Overweightness/Obesity and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

“…The following data were extracted from the included studies: first author, year of publication, country, study design, and characteristics of participants (sample size, mean age, mean BMI), conception method, causes of infertility, diagnostic criteria for PCOS, the outcome variables and the definition of outcomes. The quality of the selected studies was assessed using the Newcastle-Ottawa quality assessment scale with a maximum score of 9 representing the highest quality [ 31 , 32 ].…”

Marfan syndrome

“…6,7 Management People affected by MFS can have average lifespans with proper treatment, such as cardiovascular medications and regular specialist follow-ups. 6,17,18 Proper treatment includes the appropriate comprehensive multidisciplinary team (cardiologist, clinical geneticist, ophthalmologist, orthopedist, and cardiothoracic surgeon) 3 and other specialists as required. [19][20][21] The CDC recommends evaluation by a cardiologist and cardiothoracic surgeon yearly.…”