Oral health status in epileptic children

Gürbüz, Taşkın; Tan, Hüseyin

doi:10.1111/j.1442-200x.2009.02965.x

Cited by 31 publications

(38 citation statements)

References 21 publications

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“…The dental conditions of epilepsy patients were significantly worse than non-epileptic age-matched groups. furthermore, poorly controlled epilepsy patients had worse oral health compared to patients who had better controlled epilepsy (29).…”

Section: Discussionmentioning

confidence: 99%

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Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

Oktay¹,

Alev²,

Öztürk³

et al. 2016

Marmara Pharm J

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ABSTRACTvalproic acid (2-n-propylpentanoic acid, vPA), the most widely used antiepileptic drug, has potential adverse effects and it can disrupt the oxidant and antioxidant balance. Edaravone (3-methyl-1-phenyl-2-pyrazoline-5-one, EDA) is a potent free radical scavenger. In this study, the effect of EDA on gingiva in vPA induced toxicity was investigated. female Sprague Dawley rats were randomly divided into four groups: control group, EDA (30 mg/kg/day) given group, vPA (0.5 g/kg/day) given group, and vPA+EDA (in same dose and time) given group. EDA and vPA were given intraperitoneally for seven days. Total protein, lipid peroxidation (LPO), sialic acid (SA) and reduced glutathione (GSH) levels and catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), myeloperoxidase (mPO), alkaline phosphatase (ALP), acid phosphatase (ACP), sodium potassium ATPase (na + /K + -ATPase) and tissue factor (Tf) activities were determined in gingiva homogenates. The vPA-induced increases were statistically significant for mPO (p<0.01), ACP (p<0.01), na + /K + -ATPase (p<0.05) and Tf (p<0.01) activities, but not for LPO level and ALP activities. EDA treatment markedly blunted all such elevated anomalies. Conclusively, vPA induced oxidative and inflammatory gingival tissue damage, reactions that were appreciably reversed by concurrent administration of EDA.

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Section: Discussionmentioning

confidence: 99%

“…These drugs alter the metabolism and cause osteopenia and osteomalacia by leading clearance of vitamin D (29). Anticonvulsant drugs cause changes in bone metabolism and calcium levels and these drugs may lead to a decrease in bone mass (39).…”

Section: Discussionmentioning

confidence: 99%

Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

Oktay¹,

Alev²,

Öztürk³

et al. 2016

Marmara Pharm J

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“…The subjects that took antiepileptic medicines had significantly higher OHI-S index (2.50), unlike the subjects not taking medicine (1.53), (p=0.0001; Z=4.92). In the study by Gurbuz, who looked at epileptic patients, achieved a lower DMFt number value (3.5±3.79) [8].…”

Section: Discussionmentioning

confidence: 99%

The impact of antiepileptic drugs on the condition of the oral cavity in children and youth affected with epilepsy

Mielnik−Błaszczak

Skawińska

Michałowski

et al. 2015

Polish Journal of Public Health

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Introduction. Epilepsy is one of the most common neurological disorders. Epileptic patients taking antiepileptic pharmaceuticals often suffer from hypertrophic changes in gums. It is well established that dental hypertrophies within the alveolar tissue appear more often in children and young people being treated for epilepsy than adults. Aim. The aim of the study was to determine the influence of antiepileptic drug therapy on the oral cavity of both children and young people suffering from epilepsy. Material and methods. The investigation consisted of a clinical examination and a questionnaire looking at 107 individuals of both sexes, all aged between 6 and 18. They were all residents of the Lublin region. The study looked at the individuals residing in the Social Care Center in Lublin and patients treated at the Children’s Clinical Hospital in Lublin. The oral analysis included an examination of hard tissues, the state of oral hygiene according to Green and Vermillion (OHI-S), periodontal treatment needs (CPITN), status of gums and mucosal membrane pathological assessment of the oral cavity and determination of developmental disturbances of teeth (intensity of tooth decay expressed as DMFt). Results. The patients who took antiepileptic drugs had greater treatment needs in tissues of periodontium - determined by the value of CPITN index - (1.68±0.60), unlike those subjects who had not taken any medicine (0.96±0.29), (p=0.0001; Z=-3.20). It was stated that the value of the DMFt index had been significantly higher in those subjects who had been taking antiepileptic medicines (6.80±5.16), unlike the subjects not taking medicine (4.65±3.72), (p=0.02; Z=2.40). In subjects taking antiepileptic drugs, the OHI-S index was significantly higher (2.50) unlike those subjects who had not taken any medicine (1.53), (p=0.0001; Z=4.92). Conclusions. The findings demonstrate that the hard dental tissues in children taking antiepileptic drugs require much more care. They have a higher simplified index of oral hygiene and higher index for periodontal treatment needs. Disturbances related to oral mucosal cavity and dental abnormalities occurred more frequently in children ingesting antiepileptic agents

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“…Gurbuz et al (Gurbuz & Tan, 2010) found a traumatic anterior dental injury rate of 68.8% in children with epilepsy in Erzurum, Turkey. This probably resulted from insufficient seizure control or from placing hard objects between the teeth of patients during seizures.…”

Section: Dental Status and Oral Health 421 Traumamentioning

confidence: 99%

Epilepsy and Oral Health

Gürbüz¹

2011

Novel Aspects on Epilepsy

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Oral health status in epileptic children

Abstract: Epileptic children are at an increased risk of developing caries and gingivitis compared with healthy subjects.

Cited by 31 publications

References 21 publications

Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

Edaravone ameliorates valproate-induced gingival toxicity by reducing oxidative-stress, inflammation and tissue damage

The impact of antiepileptic drugs on the condition of the oral cavity in children and youth affected with epilepsy

Epilepsy and Oral Health

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