Oral Health-Related Quality of Life and the Use of Oral and Topical Nonsteroidal Anti-Inflammatory Drugs for Pericoronitis

Alalwani, Abdullah; Buhara, Oğuz; Tüzüm, Mustafa Şenol

doi:10.12659/msm.918085

Cited by 8 publications

(14 citation statements)

References 23 publications

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“…Two ongoing RCTs were found (NCT03919942 and NCT03576105). Thus, we included seven RCTs [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ] in this systematic review. The flowchart of the search and screening of studies for the present review is shown in Figure 1 presents the flowchart of the study selection process.…”

Section: Resultsmentioning

confidence: 99%

“…This systematic review included seven RCTs conducted in the Middle East, three from Turkey [ 12 , 13 , 14 ], 1 in Saudi Arabia [ 15 ] and 1 in Iran [ 16 ]. One study was performed in England [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study [ 18 ] did not report the country that it was conducted. Two studies [ 12 , 15 ] registered their study protocol. Only one study [ 15 ] reported following CONSORT [ 19 ] to conduct the study.…”

Section: Resultsmentioning

confidence: 99%

“…For the inclusion criteria, most of the included studies considered participants presenting pain [ 12 , 15 , 16 ], localized swelling [ 12 , 15 , 16 ], trismus [ 15 , 18 ], lymphadenopathy [ 13 , 16 ], recurrent infections [ 15 ] and malaise [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

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Interventions for Early-Stage Pericoronitis: Systematic Review of Randomized Clinical Trials

et al. 2022

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Background: To investigate the efficacy and safety of interventions for early stage pericoronitis. Methods: We searched for randomized controlled trials (RCTs) in databases from inception to July 2020, without language restriction. RCTs assessing adolescents and adults were included. Results: Seven RCT with clinical diversity were included, so, it was not possible to conduct meta-analyses. Individual study data showed an improvement in oral health quality of life in favor of topical benzydamine versus diclofenac capsule (Mean difference (MD) −1.10, 95% Confidence interval (CI) −1.85 to −0.35), and no difference between topical benzydamine and flurbiprofen capsule (MD −0.55 95% CI −1.18 to 0.0). There was no difference between diclofenac and flurbiprofen capsules (MD 0.55, 95% CI −0.29 to 1.39). An imprecise estimate of effects was found for all outcomes, considering (i) oral versus topic pharmacological treatment, (ii) different oral pharmacological treatments, (iii) pharmacological treatment associated with laser versus placebo laser, (iv) pharmacological treatment associated with different mouthwashes, and (v) conventional treatment associated to antimicrobial photodynamic therapy versus conventional treatment, with low to very low certainty of evidence. Conclusions: Until future well-designed studies can be conducted, the clinical decision for early stage pericoronitis should be guided by individual characteristics, settings and financial aspects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Interventions for Early-Stage Pericoronitis: Systematic Review of Randomized Clinical Trials

et al. 2022

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“…Thus, pain relief should be an integral part of pericoronitis treatment. The analgesics of choice should be nonsteroidal anti-inflammatory drugs (NSAIDs) [ 66 ]. Whether by administering local anesthesia or topical anesthesia, pain management is also an essential part of local treatment as it increases patient compliance during the procedure.…”

Section: Part A: Pericoronitis Evidence-based Therapymentioning

confidence: 99%

A Review of Evidence-Based Recommendations for Pericoronitis Management and a Systematic Review of Antibiotic Prescribing for Pericoronitis among Dentists: Inappropriate Pericoronitis Treatment Is a Critical Factor of Antibiotic Overuse in Dentistry

Schmidt

Kunderová

Pilbauerova

et al. 2021

IJERPH

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This work provides a narrative review covering evidence-based recommendations for pericoronitis management (Part A) and a systematic review of antibiotic prescribing for pericoronitis from January 2000 to May 2021 (Part B). Part A presents the most recent, clinically significant, and evidence-based guidance for pericoronitis diagnosis and proper treatment recommending the local therapy over antibiotic prescribing, which should be reserved for severe conditions. The systematic review includes publications analyzing sets of patients treated for pericoronitis and questionnaires that identified dentists' therapeutic approaches to pericoronitis. Questionnaires among dentists revealed that almost 75% of them prescribed antibiotics for pericoronitis, and pericoronitis was among the top 4 in the frequency of antibiotic use within the surveyed diagnoses and situations. Studies involving patients showed that antibiotics were prescribed to more than half of the patients with pericoronitis, and pericoronitis was among the top 2 in the frequency of antibiotic use within the monitored diagnoses and situations. The most prescribed antibiotics for pericoronitis were amoxicillin and metronidazole. The systematic review results show abundant and unnecessary use of antibiotics for pericoronitis and are in strong contrast to evidence-based recommendations summarized in the narrative review. Adherence of dental professionals to the recommendations presented in this work can help rapidly reduce the duration of pericoronitis, prevent its complications, and reduce the use of antibiotics and thus reduce its impact on patients' quality of life, healthcare costs, and antimicrobial resistance development.

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Assessment of a combined mouthwash on pain relief in pericoronitis: a randomized clinical study

Arekhi,

Mortazavi,

Bahramnejad

et al. 2024

BMC Oral Health

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Background Pericoronitis, an inflammation near wisdom teeth, often occurs when they are partially emerged, especially in the lower jaw. Commonly, the gingiva partially envelops the tooth. Treatments vary from gingival surgery to extraction. This study assessed the efficacy of a mouthwash with Chlorhexidine, Benzydamine, Nanosilver, Amoxicillin, and Metronidazole for pain reduction and enhancement of maximum mouth opening in acute pericoronitis cases. Materials and methods In this randomized controlled clinical trial conducted at the Gorgan Dental Faculty, 48 pericoronitis patients were randomized into two groups. The control group used a 0.12% chlorhexidine mouthwash, while the case group used a mouthwash containing Chlorhexidine, Benzydamine, Nanosilver, Amoxicillin, and Metronidazole. The study recorded Visual Analog Scale (VAS) scores for 7 days, and Maximum mouth opening (MMO) was measured at the start and after 7 days. The analysis was performed using SPSS v20. Results In this study, we compared the effects of a combined mouthwash with those of a chlorhexidine mouthwash on pericoronitis in 48 patients, with an average age of 21.56 years. No significant difference in pain reduction was observed between the groups; however, both groups exhibited decreased pain and improved MMO post-treatment. The gender distribution was balanced across both groups. Conclusion The results indicate that both chlorhexidine mouthwash and combined mouthwash significantly improved maximum mouth opening. Nonetheless, there were no notable differences in efficacy between the two groups. These findings suggest that these mouthwashes may be beneficial for oral hygiene, warranting further in-depth research. Trial registration Registered on 12/03/2023, registration number IRCT20230104057046N1.

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Oral Health-Related Quality of Life and the Use of Oral and Topical Nonsteroidal Anti-Inflammatory Drugs for Pericoronitis

Cited by 8 publications

References 23 publications

Interventions for Early-Stage Pericoronitis: Systematic Review of Randomized Clinical Trials

Interventions for Early-Stage Pericoronitis: Systematic Review of Randomized Clinical Trials

A Review of Evidence-Based Recommendations for Pericoronitis Management and a Systematic Review of Antibiotic Prescribing for Pericoronitis among Dentists: Inappropriate Pericoronitis Treatment Is a Critical Factor of Antibiotic Overuse in Dentistry

Assessment of a combined mouthwash on pain relief in pericoronitis: a randomized clinical study

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