Oral Health-Related Quality of Life in Children and Adolescents with Osteogenesis Imperfecta: cross-sectional study

Najirad, Mohammadamin; Shin, Mang; Rauch, Frank; Sutton, V. Reid; Lee, Brendan; Retrouvey, Jean-Marc; Esfandiari, Shahrokh

doi:10.1101/424812

Cited by 6 publications

(11 citation statements)

References 21 publications

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“…Tosi et al () reported health issues encountered by adults with OI throughout their lifespan. For instance, about 50% of individuals with OI are born with dentinogenesis imperfecta (Biria, Abbas, Mozaffar, & Ahmadi, ), which affects the quality of life of children, adolescents, and adults (Najirad et al, ). Second, the present review excluded case reports on skeletal manifestations because it was addressed by the OI community (Forlino et al, ; Forlino & Marini, ; Rauch & Glorieux, ), and rather focused on the extra skeletal manifestations of OI due to paucity of research.…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations of osteogenesis imperfecta in adulthood: An integrative review of quantitative studies and case reports

Chougui

Addab

Palomo

et al. 2020

American J of Med Genetics Pt A

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Osteogenesis imperfecta (OI) is a rare genetic disorder of the bones caused by a mutation in Type I collagen genes. As adults with OI are aging, medical concerns secondary to OI may arise. This integrative review sought to review, appraise, and synthesize the clinical manifestations faced by adults with OI. Four electronic bibliographic databases were searched. Published quantitative, qualitative, and mixed‐methods studies, as well as case reports from 2000 to March 2019, addressing a clinical manifestation in adulthood, were reviewed. Eligible studies and case reports were subsequently appraised using the Mixed Methods Appraisal Tool and Case Report Checklist, respectively. Twenty quantitative studies and 88 case reports were included for review regardless of the varying methodological quality score. These studies collectively included 2,510 adults with different OI types. Several clinical manifestations were studied, and included: hearing loss, cardiac diseases, pregnancy complications, cerebrovascular manifestations, musculoskeletal manifestations, respiratory manifestations, vision impairment, and other clinical manifestations. Increased awareness may optimize prevention, treatment, and follow‐up. Opportunities to enhance the methodological quality of research including better design and methodology, multisite collaborations, and larger and diverse sampling will optimize the generalizability and transferability of findings.

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Section: Discussionmentioning

confidence: 99%

Clinical manifestations of osteogenesis imperfecta in adulthood: An integrative review of quantitative studies and case reports

Chougui

Addab

Palomo

et al. 2020

American J of Med Genetics Pt A

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“…The latter seems to be related to vertically small jaws and consequent anterior growth rotation of the lower jaw [10]. The quality of life of patients with OI may be impaired by aesthetic and, especially, functional concerns related to both DI and malocclusions, typically reverse overjet, posterior crossbite and open bite [12,13]. The aetiological sequences behind these occlusal features are only partly understood.…”

Section: Introductionmentioning

confidence: 99%

Dental and dentoalveolar dimensions in individuals with osteogenesis imperfecta

Waltimo‐Sirén

Tuurala

Säämäki

et al. 2021

Acta Odontologica Scandinavica

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Objective: This cross-sectional study compared tooth and dental arch dimensions of individuals with Osteogenesis imperfecta (OI) and healthy controls. Material and Methods: The 37 OI patients and 37 controls were aged 10 to 74 years. Mesio-distal tooth size, dental arch dimensions, and palatal height were measured from dental models. The differences between the patient and control groups were analysed statistically with a t-test, chi-square test, and Mann-Whitney U test. Results: The average mesio-distal tooth size of individuals with OI was smaller by 0.1 to 0.8 mm, corresponding to 1.4 to 7.3% of the size of the tooth. The patients and controls showed similar anteriorposterior lengths of maxillary and mandibular arches. The OI patient group exhibited increasingly wider maxillary dental arches posterior to the canines and a shallow palate. Conclusions: Reduced tooth size is a developmental feature of OI and a shallow palate a characteristic possibly associated with previously documented imparity of vertical jaw development. Observed posterior widening of the dental arches may follow from altered tongue position. Smaller tooth size can be favourable from orthodontic point of view in alleviating crowding, but it might further predispose to fracturing of teeth which is a considerable risk associated with dentine abnormality. The shallow jawbones may initiate development of posterior open bite, rare in general population but relatively often encountered in OI.

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“…Dental problems such as dentinogenesis imperfecta (DI), agenesis, impacted teeth, and ectopic eruption contribute to malocclusion in this population [10,11]. These anomalies that develop in early life and worsen with age in the OI population can lead to difficulties chewing, biting, and speaking and can cause pain and discomfort [12].…”

Section: Introductionmentioning

confidence: 99%

The impact of osteogenesis imperfecta severity on oral health-related quality of life in Spain: a cross-sectional study

Elfituri,

De Nova,

Najirad

2024

Orphanet J Rare Dis

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Background Osteogenesis imperfecta (OI) affects dental and craniofacial development; therefore, it can influence oral health-related quality of life (OHRQoL). The objective of this study was to explore the influence of the severity of OI on OHRQoL in adults older than eighteen years residing in Spain. Method Adults with OI were recruited from the Spanish Association of Crystal Bone (AHUCE) foundation. OHRQoL was evaluated using the Spanish version of the Oral Health Impact Profile questionnaire (OHIP-14sp), oral hygiene habits, and a dental care survey. Clinical and radiological dental examinations were performed to evaluate the patients’ oral conditions. Results A total of 65 adults (n = 46 females) aged between nineteen and sixty-two years who were diagnosed with OI and classified as type I, III, and IV (n = 20, 14, and 31, respectively) participated in this research. The total OHIP-14sp scores were significantly greater (worse) for type III (23 [SD = 10]) and type IV (21.4 [SD = 12]) than for type I (13.8 [SD = 6]) (P < 0.05). The negative impact of OHRQoL was due to the association of type III OI with all domains except for the handicap domain, while type IV OI was associated with the physical disability, social disability, and handicap domains (P < 0.05 for all). Conclusion The severity of OI negatively impacted OHRQoL in adults. This association was statistically significant.

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Oral Health-Related Quality of Life in Children and Adolescents with Osteogenesis Imperfecta: cross-sectional study

Cited by 6 publications

References 21 publications

Clinical manifestations of osteogenesis imperfecta in adulthood: An integrative review of quantitative studies and case reports

Clinical manifestations of osteogenesis imperfecta in adulthood: An integrative review of quantitative studies and case reports

Dental and dentoalveolar dimensions in individuals with osteogenesis imperfecta

The impact of osteogenesis imperfecta severity on oral health-related quality of life in Spain: a cross-sectional study

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