Oral health-related quality of life in patients with early rheumatoid arthritis is associated with periodontal inflammation and painful temporomandibular disorders: a cross-sectional study

Abstract

Objectives To evaluate oral health-related quality of life (OHRQoL) in early rheumatoid arthritis (ERA) patients and individuals at risk of rheumatoid arthritis (RA) compared to healthy controls, and to explore possible associated factors. Materials and methods Fifty ERA patients, 50 at-risk individuals, and 50 age and gender matched healthy controls were recruited. OHRQoL (Oral Health Impact Profile-14 (OHIP-14)); number of decayed, missing, and filled teeth (DMFT); denture use; periodontal inflamed surface area (PISA); xerostomia (xerostomia inventory (XI)); and possible TMD (-pain) diagnoses were recorded. The groups were compared on these variables. Subsequently, backward multiple regression analyses were performed for the ERA and at-risk groups, with OHRQoL as the dependent variable and gender, age, DMFT, denture use, PISA, XI, non-painful TMD, and TMD pain as independent variables. Results At-risk individuals had higher XI scores (U = 789.5, z = -3.181, p = 0.001, r = -0.32) and higher prevalence of TMD pain (p = 0.046, OR = 4.57; 95% CI 0.92–22.73) than healthy controls and higher OHIP-14 scores than the ERA group (U = 894.5, z = -2.418, p = 0.016, r = -0.24), while no difference in OHIP-14 was found between the control group and both other groups. For ERA patients, OHRQoL was associated with PISA and TMD pain (R2 = 0.498, p < 0.001). For at-risk individuals, OHRQoL was associated with XI score (R2 = 0.410, p < 0.001). Conclusions Alertness of health professionals to TMD pain and periodontal inflammation in ERA patients and to xerostomia and TMD pain in at-risk individuals is recommended. Clinical relevance The results of this study address orofacial aspects that require attention of health professionals in the timeframe around RA onset. Trial registration: Dutch National Trial Register (NTR, NTR6362)

Evaluation of oral health-related quality of life in a sample of Iraqi patients with rheumatoid arthritis: a case-control study

“…In line with age, gender exhibited a positive but weak prediction with OHIP-14 scores, yet this effect was not statistically significant (p > 0.05). This suggests that, in this study, gender differences did not significantly predict oral health impact, aligning with the findings of Branco et al and Kroese et al [7,15].…”

“…The interquartile range of the OHIP-14 scores suggests that some patients and controls may experience varying degrees of impact on oral health within each group. Similar outcomes have been reported in various published studies [7,14,15].…”

Periodontal Inflamed Surface Area (PISA) associates with composites of salivary cytokines

“…Several studies have shown that PISA is associated with several systemic diseases including CVD [ 27 ], dementia [ 28 ], rheumatoid arthritis [ 29 ] kidney disease [ 30 ], diabetes [ 31 ]. PISA has also been found to be associated with plasma CRP [ 30 , 32 ], a measure of systemic inflammation.…”

Oral Health and Frailty in Community-Dwelling Older Adults in the Northern Netherlands: A Cross-Sectional Study

“…Secondly, even though the OHIP-NL14 is associated with numerous oral health indicators, this study did not include a physical assessment of the dental status by an oral health care professional and oral health was self-reported. However, it has been reported that oral health assessed by dental health care professionals often agrees with self-reported oral health [26,41]. Considering the OHIP-NL14 as a measurement for oral health allows for a shift from traditional medical/dental criteria, such as teeth count or oral pain, to an oral health assessment that focuses on a person's social and emotional experience and physical functioning.…”