Aim The aim of this qualitative study was to explore the role of parents of children with Down syndrome (DS) and the role of special education teachers in creating and maintaining oral health behaviors in children with (DS) in primary school in Jeddah. Methods The information was collected through semi-structured interviews with 45 participants, 18 parents and 27 teachers. All interviews conducted in Arabic, then transcription in English, general thematic analysis was adopted in this study. Results A number of barriers related to maintaining good oral health for children are mentioned due to: Saudi lifestyle, routine and cultural standards. Moreover, there was a lack of knowledge related to promoting oral health and children's demand to brush their teeth. A preventable visit to the dentist was not necessary according to the participants, as it was required only when seeking treatment. The teachers agreed on the importance of having a school program to promote oral health and expressed willingness to participate in it; however, they also expressed their lack of knowledge about promoting it. This study concluded that Jeddah residents are keen to maintain the health of their children but do not know the correct ways to do this; moreover, they have some concern about doing so. A number of interventions are needed to improve children's oral health; these interventions need to target parents, teachers and children.Conclusion: the participants showed oral health was something they valued, and confidence for educating children and improving their oral health was low.