This discussion paper focuses on some particularly challenging aspects of bridging primary care and oral health care for low health literacy populations. Because of the lack of physical proximity between most dental and medical practices, even in some co-located places, many patients and providers have diffi culty navigating this divide. This discussion paper expands on three of the recommendations from a paper commissioned for the Roundtable on Health Literacy of the National Academies of Sciences, Engineering, and Medicine. The discussion paper focuses on the weak links in the integration process of communication, coordination, and referral across professions. Examples and health literacy solutions are presented, such as having personnel assist patients with navigation, electronic tools for appointments and guidance, shared electronic health records, referral guidelines, and educational curricula for health care providers to increase their interprofessional knowledge and practice. Health literacy strategies and systems are needed to establish formal communication, collaboration, and referral networks across professions at all levels. Practice-based research can advance the most eff ective models. Our vision is a patient-centered health home that includes bidirectional access and communication across oral health and primary care.