Oral health in liver transplant children administered cyclosporin A or tacrolimus

Wondimu, Biniyam; Németh, Andrea H.; Modéer, Thomas

doi:10.1046/j.0960-7439.2001.00305.x

Cited by 35 publications

(32 citation statements)

References 19 publications

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“…Frequent cases of green dental discolouration (50–61.3%) in children with hyperbilirubinaemia and biliary atresia were reported [23, 26]. In the present study they occurred in all children with an early childhood medical history of jaundice.…”

Section: Discussionsupporting

confidence: 56%

Oral health and liver function in children and adolescents with cirrhosis of the liver

Olczak‐Kowalczyk

Kowalczyk²,

Krasuska-Sławińska

et al. 2014

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IntroductionPeople with cirrhosis of the liver are predisposed to developing oral lesions. The occurrence and type of lesion depend on the degree of liver function impairment and its type, and on the severity and duration of systemic diseases. In children, the age at which the early symptoms of liver disease are experienced is also of great importance.AimTo assess the prevalence of oral pathological lesions in children and adolescents with cirrhosis of the liver, and their correlation with the degree of liver function impairment.Material and methodsClinical and laboratory results of liver function tests (Model of End-Stage Liver Disease/Score of Paediatric End-Stage Liver Disease, Child-Pugh score) were assessed in 35 patients with cirrhosis of the liver. The average age of the patients was 10.7 ±4.74 years. All patients also had their oral cavities examined (mucosa, gingiva – GI, hygiene – PLI, teeth – dmft/dmfs and DMFt/DMFs, DDE Index and Candida spp. presence) and this was then correlated to the degree of liver function impairment.ResultsAccording to the Child-Pugh scale, 16 patients were class A and 19 were class B/C. Jaundice during the first 3 years of life occurred in 9 patients. Mucosal lesions were found in 26 out of 35 patients (74%), including 10 out of 16 (63%) in Child-Pugh group A, and 16 out of 19 (84%) in group B/C (NS – non significant). Oral candidiasis occurred more often in class B/C than in class A (47.4% vs. 12.5%; p < 0.05). The GI index (Gingival Index) and PLI index (Dental Plaque Index) did not differ between the groups (A vs. B/C) but correlated in the whole group (R = 0.58) as well as in subgroups A (R = 0.65) and B/C (R = 0.59). Dmft/dmfs and DMFt/DMFs indexes did not differ between groups A and B/C, and neither did the DMFt/DMFs in patients with/without enamel defects.ConclusionsOral mucosal lesions are commonly found in children with cirrhosis of the liver. Advanced liver disease promotes oral candidiasis. Severity of gingivitis correlates with the presence of dental plaque.

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Section: Discussionsupporting

confidence: 56%

Oral health and liver function in children and adolescents with cirrhosis of the liver

Olczak‐Kowalczyk

Kowalczyk²,

Krasuska-Sławińska

et al. 2014

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“…An increased PI among children with a history of liver impairment was similarly documented by Baygin et al [11] and Olczak-Kowalczyk et al [3]. Also, Wondimu et al [21] found an increased visible PI among pediatric liver transplant recipients. The poor oral hygiene detected among children with a history of CLD indicates a need for improvement in preventive oral health care.…”

Section: Discussionsupporting

confidence: 58%

Oral Health Status of Kuwaiti Children with a History of Chronic Liver Disease

2019

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Objective: To investigate the oral health status and dental manifestations of children with a history of chronic liver disease (CLD) compared to healthy children.Subjects and Methods: Twenty children (15 boys and 5 girls) with a history of CLD were compared to 20 healthy controls matched for age and gender. The clinical examination was carried out by the same dentist. Caries prevalence, using the decayed, missing, and filled primary and permanent teeth indices (dmft/DMFT), was recorded. Developmental enamel defects, plaque scores, and gingival overgrowth were also investigated. Results: No statistically significant differences were found in mean dmft scores for children with a history of CLD (4.9 ± 5.4) and for healthy individuals (3.9 ± 4.5). However, the mean DMFT score was significantly higher (p =0.025) in children with CLD (4.2 ± 4.6) compared to controls (1.7 ± 1.6). The mean decayed teeth parameter (DT) was also significantly higher in children with CLD (p =0.004). All patients with CLD exhibited enamel defects compared to only 33% in the control group (p< 0.05). A higher mean plaque index was observed in children with a history of CLD (p< 0.001). Also, a positive correlation for gingival overgrowth was noted in patients with a history of CLD (p< 0.05). Green staining was evident only in the permanent dentition of 1 child with CLD. Conclusion: Children with a history of CLD exhibited a high caries prevalence, high plaque scores, and more enamel defects compared to healthy subjects. Gingival overgrowth is less prevalent among pediatric liver transplant patients on tacrolimus therapy.

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“…A intervenção cirúrgica pode ser benéfica temporariamente, mas a recidiva da hiperplasia gengival é inevitável enquanto o uso da ciclosporina for continuado. Uma alternativa, dependendo da gravidade do aumento gengival, é a troca da ciclosporina pelo tacrolimus (Wondimu et al, 2001). …”

Section: Complicações Orais Decorrentes Da Terapia Imunossupressoraunclassified

“…A pigmentação dentária por bilirrubina é uma das principais alterações odontológicas apresentadas nos portadores de doenças colestáticas. Os estudos de Hosey et al (1995), Wondimu et al (2001) A literatura mostrou nos últimos anos uma forte associação entre úlceras orais e uso de sirolimus. Em alguns estudos tem sido observado alta incidência de úlceras orais após troca de drogas inibidoras de calcineurina para o sirolimus e ainda que as lesões tendem a regredir após semanas de interrupção ou ajuste da dose da droga (Campistol et al, 2010).…”

Section: Hipertrofia De Pregas Sublinguaisunclassified

Avaliação de manifestações bucais em pacientes pediátricos submetidos ao transplante hepático

Vivas¹

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Oral health in liver transplant children administered cyclosporin A or tacrolimus

Abstract: No difference in caries experience or enamel defect was observed between the CsA and TAC group.

Cited by 35 publications

References 19 publications

Oral health and liver function in children and adolescents with cirrhosis of the liver

Oral health and liver function in children and adolescents with cirrhosis of the liver

Oral Health Status of Kuwaiti Children with a History of Chronic Liver Disease

Avaliação de manifestações bucais em pacientes pediátricos submetidos ao transplante hepático

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