Oral Health and Quality of Life in Candidates for Liver Transplantation

Lins, Liliane; Aguiar, Inácio; Carvalho, Fernando Martins; Souza, Lucca S; Sarmento, Viviane Almeida; Codes, Liana; Bittencourt, Paulo Lisboa; Paraná, Raymundo; Bastos, Jorge

doi:10.1016/j.transproceed.2017.01.049

Cited by 18 publications

(25 citation statements)

References 18 publications

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“…A total of 45 studies for health-related quality of life were included (see Supplementary Material). 26,31,38,49,59–99 Except for two international studies, the majority of studies reported data from Europe (21) and North America (11), and there were five from China. Most of the studies were cross-sectional and outpatient-based.…”

Section: Health-related Quality Of Life Of Patients With End-stage LImentioning

confidence: 99%

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

et al. 2018

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Background:End-stage liver disease is a common cause of morbidity and mortality worldwide, yet little is known about its symptomatology and impact on health-related quality of life.Aim:To describe symptom prevalence and health-related quality of life of patients with end-stage liver disease to improve care.Design:Systematic review.Data sources:We searched eight electronic databases from January 1980 to June 2018 for studies investigating symptom prevalence or health-related quality of life of adult patients with end-stage liver disease. No language restrictions were applied. Meta-analyses were performed where appropriate.Results:We included 80 studies: 35 assessing symptom prevalence, 41 assessing health-related quality of life, and 4 both. The instruments assessing symptoms varied across studies. The most frequently reported symptoms were as follows: pain (prevalence range 30%–79%), breathlessness (20%–88%), muscle cramps (56%–68%), sleep disturbance (insomnia 26%–77%, daytime sleepiness 29.5%–71%), and psychological symptoms (depression 4.5%–64%, anxiety 14%–45%). Erectile dysfunction was prevalent (53%–93%) in men. The health-related quality of life of patients with end-stage liver disease was significantly impaired when compared to healthy controls or patients with chronic liver disease. Compared with compensated cirrhosis, decompensation led to significant worsening of both components of the 36-Item Short Form Survey although to a larger degree for the Physical Component Summary score (decrease from average 6.4 (95% confidence interval: 4.0–8.8); p < 0.001) than for the Mental Component Summary score (4.5 (95% confidence interval: 2.4–6.6); p < 0.001).Conclusion:The symptom prevalence of patients with end-stage liver disease resembled that of patients with other advanced conditions. Given the diversity of symptoms and significantly impaired health-related quality of life, multidisciplinary approach and timely intervention are crucial.

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Section: Health-related Quality Of Life Of Patients With End-stage LImentioning

confidence: 99%

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

et al. 2018

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“…Previous studies have observed that candidates for liver transplantation have shown inadequate oral hygiene . Moreover, most of the studies state that liver transplant candidates (LTCs) present worst periodontal status, greater clinical attachment loss, and greater alveolar bone loss, when compared with healthy controls. However, some of these studies present limitations such as lack of a non‐cirrhotic control group or controls who were not matched for predictors of periodontitis .…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] Moreover, most of the studies state that liver transplant candidates (LTCs) present worst periodontal status, [10][11][12][13][14][15][16] greater clinical attachment loss, 9 and greater alveolar bone loss, 17,18 when compared with healthy controls. However, some of these studies present limitations such as lack of a non-cirrhotic control group [10][11][12]15,16 or controls who were not matched for predictors of periodontitis. 14 Furthermore, although Oettinger-Barak et al 9,17,18 have included a control group matched by age and sex, no matching or adjustment was made for smoking status and diabetes, which are two important risk factors for periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Periodontal status of liver transplant candidates and healthy controls

Profio

Inoue

Marui

et al. 2018

Journal of Periodontology

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“…Later, numerous studies have reported poor oral health status before and after transplantation [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. These reports highlighted the need for oral hygiene sensitization, as well a tight pre-and post-transplant multidisciplinary oral care [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. However, literature remains contradictory regarding the impact of periodontal diseases for the organ-transplant success [31,[33][34][35]43,44].…”

Section: Of 13mentioning

confidence: 99%

Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

et al. 2020

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This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications.

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Oral Health and Quality of Life in Candidates for Liver Transplantation

Cited by 18 publications

References 18 publications

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis

Periodontal status of liver transplant candidates and healthy controls

Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

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