Oral Hairy Leukoplakia in Immunocompetent Patients Revisited with Literature Review

Alramadhan, Saja A.; Bhattacharyya, Indraneel; Cohen, Donald M.; Islam, Mohammed N.

doi:10.1007/s12105-021-01287-8

Cited by 9 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Candida infection has been found in 34% of OLK, and Candida invasion is a significant risk factor for malignant transformation in OLK. EBV infection 7 is also strongly associated with the malignant transformation of OLK. The oral microbial environment is complex.…”

Section: Discussionmentioning

confidence: 99%

Rapid diagnosis of a complex oral mucosal infection using metagenomic next-generation sequencing: a case report

Song

Liu

et al. 2022

J Int Med Res

View full text Add to dashboard Cite

The most commonly used methods for pathogen detection and identification in oral mucosal infectious diseases are DNA or RNA quantitative polymerase chain reaction detection, bacterial or fungal cultures, and immunohistochemical analysis. These traditional methods are time-consuming and can only detect one specific targeted pathogen at a time. An efficient and sensitive method with higher species richness is urgently needed. Metagenomic next-generation sequencing (mNGS) is a new method of pathogen detection with high efficiency and sensitivity. In this case report, mNGS was used to identify the pathogens in oral mucosal tissues of a patient with complex oral mucosal infections and oral leukoplakia. Candida albicans, human gamma herpesvirus 4, and many other pathogens were identified using this method. For complex oral mucosal infections, mNGS is a more efficient and sensitive approach that can replace conventional detection methods.

show abstract

Section: Discussionmentioning

confidence: 99%

Rapid diagnosis of a complex oral mucosal infection using metagenomic next-generation sequencing: a case report

Song

Liu

et al. 2022

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…However, recent reports of immunocompetent patients without evidence of any responsible systemic diseases or medications developing OHL have emerged. 5 , 6 , 7 The only reports of targeted immunomodulation with JAK inhibition associated with reactivation of EBV is in cohort of steroid-refractory graft-versus-host disease. 8 The pathophysiology regarding the role of the JAK pathway in the reactivation of EBV is not well understood but may involve a functional impairment in dendritic cells and natural killer lymphocytes involved in clearance of virus-infected cells.…”

Section: Discussionmentioning

confidence: 99%

The development of oral hairy leukoplakia during baricitinib therapy

Ahmed,

Rahman,

Trent

et al. 2024

JAAD Case Reports

View full text Add to dashboard Cite

“…OHL is an oral mucosal disease associated with Epstein-Barr virus infection, which predominantly occurs in immunocompromised patients (e.g., from untreated HIV, haematological malignancy, and organ and bone marrow transplantation) [19,20]. However, OHL lesions have also been sporadically described in healthy subjects [21] and are quite common, unlike OHL.…”

Section: Discussionmentioning

confidence: 99%

Lingual Lichenoid Lesion Due to Dental Amalgam Fillings: Case Report and Clinical Considerations

et al. 2022

View full text Add to dashboard Cite

Oral white lesions are quite common clinical conditions in clinical dental practice. They can be an expression of different diseases, so it is crucial to achieve a correct diagnosis to start an adequate treatment. However, differential diagnosis is not always easy because the clinical appearance of oral white lesions is often similar and non-pathognomonic. We report on a 42-year-old Caucasian woman who complained of a chronic white patch on the left border of her tongue. A provisional diagnosis of oral hairy leukoplakia was made, but the patient was HIV-negative and not immunocompromised. A patch test was performed to exclude an allergic reaction, which resulted negative. Two large amalgam fillings were removed, and the lesion regressed after two weeks, suggesting a diagnosis of oral lichenoid lesions. Amalgam-associated oral lichenoid lesions could be mistaken for hairy leukoplakia when located on the lateral border of the tongue. Patch tests for dental metal series are only sometimes helpful for a diagnosis of oral lichenoid lesions. Patients should follow a careful follow-up to monitor any neoplastic derailment of the lichenoid lesions.

show abstract

Oral Hairy Leukoplakia in Immunocompetent Patients Revisited with Literature Review

Cited by 9 publications

References 22 publications

Rapid diagnosis of a complex oral mucosal infection using metagenomic next-generation sequencing: a case report

Rapid diagnosis of a complex oral mucosal infection using metagenomic next-generation sequencing: a case report

The development of oral hairy leukoplakia during baricitinib therapy

Lingual Lichenoid Lesion Due to Dental Amalgam Fillings: Case Report and Clinical Considerations

Contact Info

Product

Resources

About