Oral glucose in preterm neonates during oropharyngeal suctioning: a randomized controlled cross-over trial

Vezyroglou, Katharina; Mehler, Katrin; Kribs, Angela; Becker, Ingrid; Langhammer, Kristina; Roth, Bernhard; Hünseler, Christoph

doi:10.1007/s00431-014-2472-6

Cited by 9 publications

(9 citation statements)

References 37 publications

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“…The sample size of the studies ranged from 20 to 108, the weight of participants was more than 560 grams, and the gestational age ranged from 23 and 37 weeks. In addition, the types of respiratory support were different, including non‐invasive ventilation (Axelin et al, 2009; Rodrigues et al, 2017; Vezyroglou et al, 2015), invasive mechanical ventilation (Alinejad‐Naeini et al, 2014; Fatollahzade et al, 2020; Taplak & Bayat, 2021; Ward‐Larson et al, 2004) and both of them (Axelin et al, 2006; Desai et al, 2017; Mitchell et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Table 3 summarizes the characteristics of the interventions in each study. A total of nine non‐pharmacological interventions were reported: gentle human touch (GHT) (Fatollahzade et al, 2020), FT (Alinejad‐Naeini et al, 2014; Axelin et al, 2006, 2009; Taplak & Bayat, 2021; Ward‐Larson et al, 2004), swaddling (Desai et al, 2017), oral sucrose (Desai et al, 2017), oral glucose (OG) (Axelin et al, 2009; Rodrigues et al, 2017; Vezyroglou et al, 2015), EBM (Desai et al, 2017; Rodrigues et al, 2017), KC (Mitchell et al, 2013), breast milk smell (BMS) (Taplak & Bayat, 2021) and white noise (WN) (Taplak & Bayat, 2021). The timing of the assessment varied from 5 min before the pain procedure to 5 min after the procedure.…”

Section: Resultsmentioning

confidence: 99%

“…(Axelin et al, 2009) found that compared with opioids (5%) or FT by parents (5%), the short-term adverse reactions of OG (21.25%) are significantly increased. In another included study (Vezyroglou et al, 2015), OG delivery via nasal CPAP did not cause statistically significant serious adverse reactions, but the study found that the incidence of adverse events in the glucose group was lower than that in the placebo group. In addition, this study also found that the higher the gestational age, the lower the possibility of adverse reactions, which can partly explain the inconsistent results between the two groups.…”

Section: Abbreviationsmentioning

confidence: 94%

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Efficacy and safety of non‐pharmacological interventions for endotracheal suctioning pain in preterm infants: A systematic review

et al. 2022

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Aim To review and analyse the evidence on the efficacy and safety of non‐pharmacological interventions for preterm infants to relieve endotracheal suctioning (ES) pain. Design A systematic review per the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Methods Six databases were searched with a retrieval strategy. Parallel and crossover randomized controlled trials reporting non‐pharmacological interventions for relieving ES pain in preterm infants were identified from inception to 1 September 2021. The protocol was published in PROSPERO (CRD42021276058). Results Ten studies were retrieved, including nine different non‐pharmacological interventions. Seven studies reported that non‐pharmacological interventions in relieving pain were more effective than conventional care during ES, and three trials reported its safety. Due to the heterogeneity of pain assessment tools, time of assessment and population, only Facilitated tucking had sufficient evidence that it is a safe and effective non‐pharmacological intervention.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Abbreviationsmentioning

confidence: 94%

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Efficacy and safety of non‐pharmacological interventions for endotracheal suctioning pain in preterm infants: A systematic review

et al. 2022

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“…Vezyroglou's team believed that although the sweetener has a good analgesic effect, no serious adverse events have occurred. However, the long-term effects of sweeteners on development and neurological function are still unknown, and the dosage, concentration, and the use time of sweeteners require attention [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Summary and Analysis of Relevant Evidence for Nondrug Nursing Programs in Neonatal Operational Pain Management

Yang

Wang

2022

Emergency Medicine International

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Purpose. To summarize the relevant evidence for nondrug nursing programs in neonatal operational pain management. Methods. Computer search for the literature on neonatal procedural pain from 2015 to 2020 in Up To Date, JBI, NICE, SIGN, RNAO, NGC, PubMed, Cochrane Library, CNKI, and Wanfang database was conducted. All literature works that may meet the inclusion criteria were independently evaluated by two researchers to determine the quality grade of the articles. Results. Finally, 9 literature works were extracted, including 4 guidelines, 3 systematic reviews, and 2 evidence summaries. The relevant contents of the literature were extracted and summarized, and 20 pieces of the best evidence were obtained. Conclusion. Breast feeding, sweetener, Kangaroo mother care, sensory stimulation, nonnutritive sucking, and other nondrug nursing programs can reduce the neonatal operational pain, which has guiding significance in neonatal operational pain management.

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“…In contrast, no effect was found when applied during oropharyngeal suctioning [26]. We cannot say conclusively whether the application modified the presentation of pain-related reactions.…”

Section: Discussionmentioning

confidence: 99%

Pain-Related Reactions among Premature Infants with Gestational Age Less than 26 Weeks: An Observational Cohort Study

Martakis

Hünseler²,

Thangavelu³

et al. 2016

Neonatology

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Introduction: There is insufficient information regarding acute pain reactions among premature infants with a gestational age of less than 26 weeks and no appropriate scale for pain measurement in this age group. We hypothesized that these infants present specific reactions to a standardized pain stimulus within the first 3 days of life. Methodology: Mixed-methods, prospective, open-label, single-arm, observational study. Routine capillary or peripheral blood takes were filmed. The model consisting of a baseline, a preparatory, an interventional and a return-to-baseline phase was filmed. After a pilot evaluation, experienced medical and nursing neonatal intensive care unit (NICU) staff analysed the videos. Results: Twenty infants with gestational ages ranging from 22 weeks and 3 days to 26 weeks (mean 24 weeks) were recruited. Nineteen infants showed pain reactions, with a mean latency of 8.3 s (range 2-30). The majority presented eye movements, changes of the breath pattern and a slight increase in the mean SpO₂ value. A high degree of interrater and intrarater reliability was found. Discussion: Premature infants with a gestational age of up to 26 weeks can present a variety of discrete reactions as response to a pain stimulus within the first 72 h of life. Experienced NICU staff can perform a valid and reliable evaluation of these reactions.

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Oral glucose in preterm neonates during oropharyngeal suctioning: a randomized controlled cross-over trial

Abstract: In our study, late preterm infants in the first days of life did not benefit significantly from analgesia with glucose during oropharyngeal suctioning. The oral administration of glucose under nasal CPAP led to no serious adverse events.

Cited by 9 publications

References 37 publications

Efficacy and safety of non‐pharmacological interventions for endotracheal suctioning pain in preterm infants: A systematic review

Efficacy and safety of non‐pharmacological interventions for endotracheal suctioning pain in preterm infants: A systematic review

Summary and Analysis of Relevant Evidence for Nondrug Nursing Programs in Neonatal Operational Pain Management

Pain-Related Reactions among Premature Infants with Gestational Age Less than 26 Weeks: An Observational Cohort Study

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