Oral gabapentin for photorefractive keratectomy pain

Abstract

When added to a standardized postoperative pain regimen, gabapentin use led to no additional improvement in PRK pain control compared with a placebo at the dose and the time intervals tested.

Gabapentin for post‐operative pain management – a systematic review with meta‐analyses and trial sequential analyses

“…A total of 135 studies were included . One hundred and thirty‐two trials with 9498 patients were included for the evaluation of benefit and furthermore, three non‐randomized studies were included for the evaluation of harm.…”

“…Sixteen trials had overall low risk of bias . Seventy‐seven trials had high and 39 trials unclear risk of bias . Reasons for unclear and high risk of bias were mainly ‘selective outcome reporting’ or ‘other bias’ (Fig.…”

The TFOS International Workshop on Contact Lens Discomfort: Report of the Subcommittee on Neurobiology

“…The c-aminobutyric acid analogues gabapentin and pengabalin have been used to limit abnormal ocular sensations, but at present only to reduce conditions that cause significant eye pain. [355][356][357][358] While these antiepileptics may also have benefit for patients with more moderate forms of ocular discomfort, no data have yet been generated. Given that these agents are administered systemically and have significant potential adverse effects, the establishment of treatment guidelines for conditions such as CLD will need to be developed.…”

Validación de un modelo clínico en humanos para la evaluación del dolor agudo postoperatorio

“…6 Destacan cuatro estudios sobre la eficacia de la gabapentina en la reducción del dolor después de PRK, que muestran resultados contradictorios. 6,[99][100][101] Nissman no encontró diferencias significativas en las valoraciones globales de dolor después de la PRK entre la gabapentina y la oxicodona/acetaminofeno 5 mg/325 mg, aunque conviene aclarar que la gabapentina se asoció con un uso significativamente más frecuente de tetracaína tópica. 6…”