Oral fucoidan improves muscle size and strength in mice

McBean, Sally E.; Church, Jarrod E; Thompson, Brett K.; Taylor, Caroline J.; Fitton, J. Helen; Stringer, Damien N.; Karpiniec, Sam; Park, Ah Young; Poel, Chris van der

doi:10.14814/phy2.14730

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…Alternatively, it could be increased muscle mass. There are reports of seaweed and skeletal muscle hypertrophy (Korivi et al., 2019 ) and muscle‐strengthening effects via fucoidan (McBean et al., 2021 ), so RS may also have a muscle‐mass‐increasing effect.…”

Section: Discussionmentioning

confidence: 99%

Lipid‐ and glucose‐lowering effects of Rhamnan sulphate from Monostroma nitidum with altered gut microbiota in mice

Shimada,

Zang,

Ishimaru

et al. 2024

Food Science & Nutrition

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Rhamnan sulphate (RS) is a sulphated polysaccharide found in green algae such as Monostroma nitidum that exhibits various biological functions, including anticoagulant, antitumour, antiviral, and anti‐obesity properties. In our previous clinical trial, we demonstrated that RS intake improves constipation. However, no specific bacteria showed a significant (p < .05) change. Notably, these results were obtained after a short RS inoculation period of only 2 weeks. In the present study, to evaluate the long‐term effects of RS on the gut microbiota, we orally administered RS to BALB/c mice for 11 weeks, analyzed their blood biochemical data, and performed 16s rRNA‐sequencing. Oral administration of RS increased body weight with increased food intake, whereas plasma total cholesterol and fasting plasma glucose levels decreased. RS‐fed mice showed lower fasting insulin levels (p < .1) and decreased homeostatic model assessment for insulin resistance (HOMA‐IR, p < .0001), suggesting that RS improved insulin resistance. In the feces of mice, the amounts of acetic and propionic acids increased. In the gut microbiota, predictive metagenomic profiling using the phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt2) revealed functional alterations in Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways in RS‐fed mice. Corresponding to the blood glucose‐lowering effect, the glycolysis and tricarboxylic acid (TCA) cycle pathways were activated. In addition, the Firmicutes/Bacteroides (F/B) ratio, which may be associated with various health outcomes, was also reduced. These results suggest that the blood glucose‐lowering effect, improvement in insulin resistance, and lipid‐lowering effect of RS may be due to changes in the intestinal microbiota.

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Section: Discussionmentioning

confidence: 99%

Lipid‐ and glucose‐lowering effects of Rhamnan sulphate from Monostroma nitidum with altered gut microbiota in mice

Shimada,

Zang,

Ishimaru

et al. 2024

Food Science & Nutrition

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“…Its neuroprotective effects against brain injury, amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease were reviewed [ 140 ]. Fucoidans supplementation in the mice mitigates the musculoskeletal changes and promotes muscle health and performance [ 141 ]. They suppress tumor cell proliferation factors and metastasis by increasing cell apoptosis and angiogenesis inhibition [ 142 ].…”

Section: Natural Products and Compounds As Possible Agents To Counter...mentioning

confidence: 99%

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Das,

Sakr,

Al-Huseini

et al. 2023

Plants

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There are various herbicides which were used in the agriculture industry. Atrazine (ATZ) is a chlorinated triazine herbicide that consists of a ring structure, known as the triazine ring, along with a chlorine atom and five nitrogen atoms. ATZ is a water-soluble herbicide, which makes it capable of easily infiltrating into majority of the aquatic ecosystems. There are reports of toxic effects of ATZ on different systems of the body but, unfortunately, majority of these scientific reports were documented in animals. The herbicide was reported to enter the body through various routes. The toxicity of the herbicide can cause deleterious effects on the respiratory, reproductive, endocrine, central nervous system, gastrointestinal, and urinary systems of the human body. Alarmingly, few studies in industrial workers showed ATZ exposure leading to cancer. We embarked on the present review to discuss the mechanism of action of ATZ toxicity for which there is no specific antidote or drug. Evidence-based published literature on the effective use of natural products such as lycopene, curcumin, Panax ginseng, Spirulina platensis, Fucoidans, vitamin C, soyabeans, quercetin, L-carnitine, Telfairia occidentalis, vitamin E, Garcinia kola, melatonin, selenium, Isatis indigotica, polyphenols, Acacia nilotica, and Zingiber officinale were discussed in detail. In the absence of any particular allopathic drug, the present review may open the doors for future drug design involving the natural products and their active compounds.

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“…Chen et al reported that dietary supplement of fucoidan can prevent cancer cachexia-associated muscle atrophy in BALB/c mice during chemotherapy, which may be associated with suppressed muscle wasting-related genes including FoxO3a, MuRF1, and MAFbx and enhanced IGF-1dependent protein synthesis [128]. Oral administration of fucoidan for 4 weeks improves cross-sectional area of extensor digitorum longus fibers and soleus fibers and enhances the expression of MHC in gastrocnemius muscles muscle in C57BL/6 mice [130].…”

Section: Polysaccharidesmentioning

confidence: 99%

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Wang

Liu²,

Quan

et al. 2021

Nutrients

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Imbalance of protein homeostasis, with excessive protein degradation compared with protein synthesis, leads to the development of muscle atrophy resulting in a decrease in muscle mass and consequent muscle weakness and disability. Potential triggers of muscle atrophy include inflammation, malnutrition, aging, cancer, and an unhealthy lifestyle such as sedentariness and high fat diet. Nutraceuticals with preventive and therapeutic effects against muscle atrophy have recently received increasing attention since they are potentially more suitable for long-term use. The implementation of nutraceutical intervention might aid in the development and design of precision medicine strategies to reduce the burden of muscle atrophy. In this review, we will summarize the current knowledge on the importance of nutraceuticals in the prevention of skeletal muscle mass loss and recovery of muscle function. We also highlight the cellular and molecular mechanisms of these nutraceuticals and their possible pharmacological use, which is of great importance for the prevention and treatment of muscle atrophy.

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Oral fucoidan improves muscle size and strength in mice

Cited by 6 publications

References 37 publications

Lipid‐ and glucose‐lowering effects of Rhamnan sulphate from Monostroma nitidum with altered gut microbiota in mice

Lipid‐ and glucose‐lowering effects of Rhamnan sulphate from Monostroma nitidum with altered gut microbiota in mice

Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

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