Oral focal mucinosis of the hard palate and gingiva

Tobouti, Priscila Lie; Horikawa, Fernando Kendi; Matuck, Bruno Fernandes; Sousa, Suzana Cantanhede Orsini Machado de; Alves, Fábio Abreu

doi:10.4322/acr.2018.044

Cited by 7 publications

(30 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since then, approximately 100 well-documented cases of OFM have been reported in the literature. [1][2][3][4][5] To the best of our knowledge, this study represents the largest series of OFM cases reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to CFM, which is more prevalent in males, 2,6,38 our review of the literature showed that most oral cases affect adult women in the fourth and fifth decade of life, with a mean age of 39.1 years and 2.1:1 female-to-male ratio ( Occurrence in the retromolar region and lips ( Figure 2C-D), as observed in our series, are excessively rare, with only a few welldocumented cases published in the literature ( Table 2). The time of evolution of both entities from diagnosis to treatment is variable, ranging from some months to years.…”

Section: F I G U R E 2 Macroscopic Appearance Of Oral Focal Mucinosismentioning

confidence: 91%

“…The time of evolution of both entities from diagnosis to treatment is variable, ranging from some months to years. 2 The clinical features of OFM are not specific. 1,3,4 Most cases present as asymptomatic sessile or pedunculated lesions with fibrous or hyperplasic appearance, 1,4,7,11,12 and are diagnosed as reactive or inflammatory lesions and benign tumors.…”

Section: F I G U R E 2 Macroscopic Appearance Of Oral Focal Mucinosismentioning

confidence: 99%

“…7,8 The gingiva and palate are the most affected sites. 2,8 Other reported sites include buccal mucosa, 9,10 tongue, 1,7,11 retromolar trigone, 11 and lips. 7 Considering the non-specific clinical appearance of OFM that makes its clinical recognition very unlikely, as well as its microscopic similarity with other oral myxoid lesions, accurate diagnosis requires careful morphological evaluation.…”

mentioning

confidence: 99%

“…1,3,4 OFM presents an indolent clinical behavior, with no tendency to recur after conservative surgical excision. 3,4 Since the first description by Tomich et al in 1974, approximately 100 cases of OFM have been reported in the English-language literature, [1][2][3][4][5] most of them as single case reports or small series.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Oral focal mucinosis: A multi‐institutional study and literature review

et al. 2020

View full text Add to dashboard Cite

Background: Oral focal mucinosis (OFM) is a rare benign condition of unknown etiology, considered the oral counterpart of cutaneous focal mucinosis. We report the clinicopathologic features of 21 cases of OFM in conjunction with a review of the literature. Methods: Clinical data were collected from the records of five oral and maxillofacial pathology services. All cases were evaluated by hematoxylin and eosin staining, histochemistry, and immunohistochemistry (vimentin, S-100, α-SMA, CD34, and mast cell). Results: The series comprised 14 females (66.7%) and seven males (33.3%), with a mean age of 48.2 ± 20.7 years (range: 8-77 years) and a 2:1 female-to-male ratio. Most of the lesions affected the gingiva (n = 6, 28.6%) and presented clinically as asymptomatic sessile or pedunculated nodules with fibrous or hyperplasic appearance. All cases were negative for S-100 protein, CD34, and α-SMA and positive for Alcian blue staining. Conservative surgical excision was the treatment in all cases, and there was only one recurrence. Conclusion: OFM is a rare benign disorder that is often clinically misdiagnosed as reactive lesions or benign proliferative processes. Dermatologists and pathologists should consider OFM in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located in the gingiva. K E Y W O R D S connective tissue diseases, diagnosis, oral focal mucinosis, oral pathology 1 | INTRODUCTION Oral focal mucinosis (OFM) is considered to be the oral counterpart of cutaneous focal mucinosis (CFM) that likely develops due to an overproduction of hyaluronic acid by fibroblasts. 1-3 As a result, a well-demarcated myxomatous tissue positive for Alcian blue (pH 2.5) is observed microscopically; which may mimic other oral myxoid lesions, such as soft-tissue myxoma, fibrous hyperplasia with myxoid degeneration, nerve sheath myxoma (NSM), myxoid neurofibroma, and mucocele. 1

show abstract

Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 2 Macroscopic Appearance Of Oral Focal Mucinosismentioning

confidence: 91%

Section: F I G U R E 2 Macroscopic Appearance Of Oral Focal Mucinosismentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Oral focal mucinosis: A multi‐institutional study and literature review

et al. 2020

View full text Add to dashboard Cite

show abstract

Peripheral calcifying odontogenic cyst in maxillary anterior gingiva: A case report

Alsabbagh,

Speakman,

Wang

et al. 2024

Clin Adv Periodontics

View full text Add to dashboard Cite

BackgroundCalcifying odontogenic cysts (Gorlin cysts) most commonly present centrally and have only rarely been reported in peripheral locations. The purpose of this report is to describe a new case of peripheral calcifying odontogenic cyst (PCOC) occurring in the anterior maxillary gingiva and to review the management and differential diagnosis of such a lesion.MethodsA 37‐year‐old female presented with a long‐standing submucosal nodule on the gingiva between the maxillary central incisors, with asymptomatic growth over the last three years. Following an initial incisional biopsy, a diagnosis of PCOC was established. To exclude the possibility of a central process, a corresponding small field of view cone beam CT scan was obtained and the patient returned for a 6 mm excisional biopsy to the depth of the periosteum.ResultsResults of these additional assessments supported the original diagnosis of PCOC. Following uneventful healing of the second biopsy, no recurrence or other clinical findings were noted at 1‐year follow‐up.ConclusionWhile rare, the peripheral variant of calcifying odontogenic cyst, and other peripheral counterparts to recognized central cysts and tumors, should be considered in a differential diagnosis for a benign gingival nodule. Gingival tissue should be submitted for histologic evaluation to ensure a neoplastic process is not present.Key points Various lesions may present on the gingiva as a “bump”; these can represent common clinical entities, such as pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, and fibroma, or more rare conditions that may not be adequately considered in the differential diagnosis. A rarely documented case of peripheral calcifying odontogenic cyst (PCOC; Gorlin cyst) on the maxillary anterior gingiva of an adult female is reported here and compared with the few other similar PCOC cases in the literature. A biopsy of gingival lesions is always necessary to establish the correct diagnosis and provide the appropriate treatment. Plain language summarySeveral different lesions can appear on the gingiva (gums). Some are quite common, and some are rare. This report documents the occurrence of a new case of calcifying odontogenic cyst (Gorlin cyst), a type of cyst that has been rarely found outside the jawbone, presenting as a “bump” on the gingiva between the maxillary central incisor teeth of an adult female. Because of the patient history, a peripheral calcifying odontogenic cyst (PCOC) was not initially suspected. Following a biopsy, a PCOC diagnosis was given. The possibility of a lesion within the bone was then excluded by an X‐ray (cone beam CT) scan examination. A second, more extensive biopsy confirmed the diagnosis and the removal of the lesion. The patient had no complications or recurrence for the following 12 months. This case highlights the need to always biopsy lesions presenting on the gums to obtain a proper diagnosis and provide the correct treatment.

show abstract

Reactive Lesions

Stoufi

2023

Periodontal Manifestations of Local and Systemic Diseases

View full text Add to dashboard Cite

Oral focal mucinosis of the hard palate and gingiva

Cited by 7 publications

References 21 publications

Oral focal mucinosis: A multi‐institutional study and literature review

Oral focal mucinosis: A multi‐institutional study and literature review

Peripheral calcifying odontogenic cyst in maxillary anterior gingiva: A case report

Reactive Lesions

Contact Info

Product

Resources

About