Oral Fluoroquinolones, Retinal Detachments, and Claims Database Studies

VanderBeek, Brian L.

doi:10.1001/jamaophthalmol.2016.0240

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…This may represent a plausible mechanism for causing retinal detachment in humans [18] and animal [19]. Some FDA reports and other epidemiologic studies reported an increased risk of retinal detachment with use of different formulations of quinolones [18,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Search Methods For Identification Of Studiesmentioning

confidence: 99%

Systemic Quinolones and Risk of Retinal Detachment II: Systematic Review of Clinical Trials

Taher¹,

Mohamed²,

M³

et al. 2021

Clin Med Rev Case Rep

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Section: Search Methods For Identification Of Studiesmentioning

confidence: 99%

Systemic Quinolones and Risk of Retinal Detachment II: Systematic Review of Clinical Trials

Taher¹,

Mohamed²,

M³

et al. 2021

Clin Med Rev Case Rep

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“…Many epidemiologic studies have examined quinoloneassociated RD risk, with conflicting results [24,[33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. In 2013, the US FDA 1 flagged a safety signal for quinoloneassociated RD risk based on spontaneous reports to FAERS 2 [38,50].…”

Section: Introductionmentioning

confidence: 99%

Systemic quinolones and risk of retinal detachment III: a nested case–control study using a US electronic health records database

Taher

Crispo

Fortin

et al. 2022

Eur J Clin Pharmacol

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Background Quinolones are popular antibiotics that are known for their potency, broad coverage, and reasonable safety. Concerns have been raised about a possible association between quinolones and retinal detachment (RD). Methods We conducted a nested case–control study using electronic health records (EHR) from the Health Facts® Database. The initial cohort included all patients who were admitted between 2000 and 2016, with no history of eye disease, and had a minimum medical history of one year. Eligible cases comprised inpatients who were first admitted with a primary diagnosis of RD between 2010 and 2015. Each eligible case was matched without replacement to five unique controls by sex, race, age, and period-at-risk. We used conditional logistic regression to calculate RD risk, adjusting for exposure to other medications, and major risk factors. Results We identified 772 cases and 3860 controls. Whereas our primary analysis of all subjects revealed no quinolone-associated RD risk, elevated but non-significant risks were noted in African Americans (ciprofloxacin and levofloxacin), those aged 56–70 years old (moxifloxacin), and women (ciprofloxacin). Conclusion Our study did not identify an elevated RD risk within 30 days following systemic administration of quinolone antibiotics. Suggestions of increased risk observed in some population subgroups warrant further investigation.

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Anti-Infectives

Fraunfelder¹,

Fraunfelder²

2021

Drug-Induced Ocular Side Effects

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Oral Fluoroquinolones, Retinal Detachments, and Claims Database Studies

Cited by 6 publications

References 6 publications

Systemic Quinolones and Risk of Retinal Detachment II: Systematic Review of Clinical Trials

Systemic Quinolones and Risk of Retinal Detachment II: Systematic Review of Clinical Trials

Systemic quinolones and risk of retinal detachment III: a nested case–control study using a US electronic health records database

Anti-Infectives

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