Oral Fleroxacin Prophylaxis in Transurethral Surgery

Gasser, Thomas C.; Wisard, M.; Frei, Reno

doi:10.1097/00005392-199607000-00047

Cited by 6 publications

(12 citation statements)

References 19 publications

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“…Furthermore, the results show that The results of the present trial confirm and extend published studies [2][3][4][5][6]9,10] in many aspects. Furthermore, the results show that The results of the present trial confirm and extend published studies [2][3][4][5][6]9,10] in many aspects.…”

Section: Resultssupporting

confidence: 91%

Single-Dose Antibiotic Prophylaxis in Transurethral Resection of the Prostate: A Prospective Randomized Trial

et al. 1999

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Section: Resultssupporting

confidence: 91%

Single-Dose Antibiotic Prophylaxis in Transurethral Resection of the Prostate: A Prospective Randomized Trial

et al. 1999

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“…Prophylactic antimicrobials should be chosen to target these bacteria. The recommended antimicrobials to prevent UTIs after TUR‐Bt are injective CEPs and oral fluoroquinolones (FQLs) 16–20,22,28,30–35 . Attention to fluoroquinolone‐resistant Escherichia coli should be paid, however, because its prevalence has been reported 36 .…”

Section: Detailed Expositionmentioning

confidence: 99%

“…Postoperative UTIs and bacteremia were the typical complications of TUR‐P, so effective AMP is necessary. Many studies on the necessity of AMP for TUR‐P have been reported 3,13,14,46–89 . Among them, many randomized comparative studies and meta‐analysis 88,89 were included.…”

Section: Detailed Expositionmentioning

confidence: 99%

“…The recommended antimicrobials to prevent UTIs after TUR-Bt are injective CEPs and oral fluoroquinolones (FQLs). [16][17][18][19][20]22,28,[30][31][32][33][34][35] Attention to fluoroquinolone-resistant Escherichia coli should be paid , however, because its prevalence has been reported. 36 In Western countries, the dosages of antimicrobials are higher than that in Japan.…”

Section: (2) Perioperative Infections In Tur-bt 13-20mentioning

confidence: 99%

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Japanese guidelines for prevention of perioperative infections in urological field

et al. 2007

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For urologists, it is very important to master surgical indications and surgical techniques. On the other hand , the knowledge of the prevention of perioperative infections and the improvement of surgical techniques should always be considered. Although the prevention of perioperative infections in each surgical field is a very important issue, the evidence and the number of guidelines are limited. Among them, the preparation of guidelines has progressed , especially in gastrointestinal surgery. The Center for Disease Control and Prevention (CDC) proposed guidelines for the prevention of surgical site infections, which have been used worldwide. In urology, the original guidelines were different from those of general surgery, due to many endourological procedures and urine exposure in the surgical field. The Japanese Society of UTI Cooperative Study Group has thus framed these guidelines supported by The Japanese Urological Association. The guidelines consist of the following nine techniques: open surgeries, laparoscopic surgeries, transurethral resection of bladder tumor, ureterorenoscope and transurethral lithotripsy, transurethral resection of the prostate, prostate biopsy, cystourethroscope, pediatric surgeries in the urological field , and extracorporeal shock wave lithotripsy and febrile neutropenia. These are the first guidelines for the prevention of perioperative infections in the urological field in Japan. Although most of these guidelines were made using reliable evidence, there are parts without enough evidence. Therefore, if new reliable data is reported , it will be necessary for these guidelines to be revised in the future. Key words:Open surgery, Laparoscopic surgery, TUR, Prostate biopsy, Cystourethroscope, ESWL. I. General remarksUrological practice mainly consists of surgical procedures, since the field of urology is a division of surgery. Therefore, it is very important to master surgical indications and surgical techniques. On the other hand , the knowledge of the prevention of perioperative infections and the improvement of surgical techniques should always be considered. Although the prevention of perioperative infections in each surgical field is a very important issue, these evidences are limited and the number of guidelines is limited. Among them, the preparation of guidelines has progressed , especially in gastrointestinal surgery. The Center for Disease Control and Prevention (CDC) proposed guidelines for the prevention of surgical site infections), 1 which have been used worldwide. In urology, the original guidelines were different from those of general surgery, due to many endourological procedures and urine exposure in the surgical field. We have thus framed these guidelines supported by The Japanese Urological Association. I-I Definition and classification of perioperative infectionsA perioperative infection is defined as an infection that occurs within one month after an operation. These infections are divided into two groups: surgical site infections (SSIs) and remote i...

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“…In the present study, incidence of postoperative symptomatic UTIs was low in patients without using AMP. The incidence (3.4%) was equivalent to that (2.3%) in patients with single dose of fluoroquinolone, which some previous studies recommended as AMP for TURBT 1–6 . Moreover, these symptomatic UTIs were easily treated by deferred use of antibiotics.…”

Section: Discussionmentioning

confidence: 80%

Discarding antimicrobial prophylaxis for transurethral resection of bladder tumor: A feasibility study

et al. 2008

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Objectives:To evaluate the feasibility of discarding antimicrobial prophylaxis (AMP) for transurethral resection of bladder tumor (TURBT). Methods: One-hundred and sixty-two patients undergoing TURBT, with no risk factors for infectious complications were included in this prospective study between April 2006 and April 2008. Forty-four patients received single oral dose of 200 mg levofloxacin for AMP (LVFX group), and the remaining 118 received no AMP (no AMP group). Rates of postoperative infectious complications were compared between the two groups. Results: There was no significant difference between the two groups in terms of baseline characteristics, including age, sex, history of TURBT, number of tumors, duration of operation and days of catheterization. Symptomatic urinary tract infections (UTIs) occurred in four patients (3.4%) in the no AMP group and one patient (2.3%) in the LVFX group (P = 0.61). All patients having UTIs were men, and were successfully treated by immediate administration of antibiotics. No patients developed extra-urinary tract infections. Conclusions: Based on our findings, AMP for TURBT in patients with no risk factors for infectious complications is not necessary. The use of antibiotics might be deferred until postoperative infections develop.

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Oral Fleroxacin Prophylaxis in Transurethral Surgery

Abstract: The oral administration of 1 daily tablet of fleroxacin for the duration of catheterization is a safe, efficacious and clinically feasible regimen.

Cited by 6 publications

References 19 publications

Single-Dose Antibiotic Prophylaxis in Transurethral Resection of the Prostate: A Prospective Randomized Trial

Single-Dose Antibiotic Prophylaxis in Transurethral Resection of the Prostate: A Prospective Randomized Trial

Japanese guidelines for prevention of perioperative infections in urological field

Discarding antimicrobial prophylaxis for transurethral resection of bladder tumor: A feasibility study

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