Oral findings in osteoporosis. Part II: Relationship between residual ridge and alveolar bone resorption and generalized skeletal osteopenia

Kribbs, Patricia J.; Smith, Dale E.; Chesnut, Charles H.

doi:10.1016/0022-3913(83)90215-9

Cited by 153 publications

(83 citation statements)

References 18 publications

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“…showed an increased remodeling [16][17][18][19][20][21], a decrease in bone volume of the mandible [22] and cancellous bone loss in the mandibular condyle [23]. The estrogen deficiency-induced osteoporosis appears to be a result of the binding of the receptor activator of the nuclear factor B (RANK) and RANK ligand (RANKL), as previously reported [24][25][26].…”

Section: Introductionsupporting

confidence: 59%

“…Thus, reduced-sclerostin did not appear to be associated with diminished ER in osteocytes in the mesial region. Other studies suggested a proapoptotic effect of estrogens on osteoclasts and osteoblasts [43,44], and therefore, it was necessary to confirm whether the reduced amount of sclerostin would be It is well known that OVX stimulates osteoclastic differentiation and subsequent bone resorption in long bones, and also shows the similar effects in alveolar bone [16][17][18][19][20][21][22].…”

Section: Immunolocalization Of Er and Tunel-positive Osteocytes In Tmentioning

confidence: 99%

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Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Guo

Liu

et al. 2012

Journal of Electron Microscopy

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This study aimed to elucidate whether estrogen deficiency would affect the synthesis of an osteocyte-derived factor, sclerostin, in the mesial region of alveolar bone. Eight 9-week-old Wister female rats were ovariectomized (OVX), and the other eight rats were Sham-operated (Sham). After 4 weeks, the interradicular septa of mandibular first molar were embedded in paraffin, and then, were histochemically examined. Sclerostin-positive osteocytes were located in a superficial layer of the mesial region of Sham bone, while the OVX mesial region showed a lesser presence of the sclerostin-reactive osteocytes. There was no significant difference in the distribution of estrogen receptor  and TUNEL-positive cells in either Sham or OVX groups. Meanwhile, the Sham mesial region demonstrated many osteoclasts, but the OVX specimens showed numerous osteoclasts in association with intense immunolabeling of the receptor activator of the nuclear factor kB ligand. Complex meshwork of cement lines was seen consistent with irregularly-distributed osteocytic lacunar-canalicular system in the OVX mesial region, compared with those of the Sham specimens. In conclusion, estrogen deficiency appears to inhibit osteocytes for sclerostin synthesis in the mesial region of the interradicular septum, mediated by accelerated bone remodeling, rather than by directly effecting osteocytes. words

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Section: Introductionsupporting

confidence: 59%

Section: Immunolocalization Of Er and Tunel-positive Osteocytes In Tmentioning

confidence: 99%

Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Guo

Liu

et al. 2012

Journal of Electron Microscopy

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“…However, with standard CT it is not possible to measure the trabecular bone structure accurately. It is also generally accepted, although not without controversy, that it is not possible to compare the trabecular bone structure from other parts of the skeleton with that of the mandible [17,21,22,23,45,46]. The purpose of this study was to measure and compare the trabecular microstructures of the alveolar bone with the basal bone of the premolar region of the mandible using micro-CT.…”

Section: Introductionmentioning

confidence: 99%

The three-dimensional microstructure of the trabecular bone in the mandible

et al. 2004

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This study investigated the three dimensional (3D) trabecular microstructure of the alveolar and basal bone in the mandible using micro-CT and compared the morphometric values of the different sites. Ten specimens were prepared and scanned using a micro-CT system. Both the alveolar and basal trabecular bone of the premolar region in the mandible were measured for the structural analysis. Cross-sectional 1024·1024 pixel images were created. From the two-dimensional (2D) images produced, 3D structural images were reconstructed. After scanning the specimen, the volumes of interest (VOI) of the alveolar and basal bone regions were selected from the 3D reconstruction images, and the structural parameters such as bone volume fraction, bone surface density, trabecular thickness, trabecular separation, trabecular number and structural model index were analyzed. The trabecular structure showed a marked variation within the sites of the specimen, especially in the basal trabecular bone inferior to the mandibular canal. In both the alveolar and basal bone regions, a mixture of both plate-like and rod-like structures was observed. The alveolar region showed a more compact, plate-type trabecular structure than the basal regions. In parametric comparison with the basal bone, the alveolar bone generally had a higher bone volume fraction, bone trabecular thickness and trabecular number, and lower bone surface density, trabecular separation and structural model index. The alveolar bone consisted of a compact bone structure with a large amount of thick plate-type trabecular bone, which was effectively resistant to the masticatory forces. As the measurements were made closer to the basal bone, a loose structure was observed with lower bone volume and fewer, thin, rod-like trabeculae.

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“…4 Residual ridge and alveolar bone density showed a significant relationship to total body calcium and regional bone loss in a study conducted by Kribbs et al 13 …”

Section: Relationship Between Systemic and Mandibular Bone Mineral Dementioning

confidence: 94%

Osteoporosis: Dental Implications

Narayanan¹,

Ashok²

2011

JIAOMR

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Oral findings in osteoporosis. Part II: Relationship between residual ridge and alveolar bone resorption and generalized skeletal osteopenia

Cited by 153 publications

References 18 publications

Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

The three-dimensional microstructure of the trabecular bone in the mandible

Osteoporosis: Dental Implications

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