Oral exposure to dibutyl phthalate exacerbates chronic lymphocytic thyroiditis through oxidative stress in female Wistar rats

Wu, Yang; Li, Jinquan; Yan, Biao; Zhu, Yuqing; Liu, Xudong; Chen, Mingqing; Li, Dai; Lee, Ching Chang; Yang, Xu; Ma, Ping

doi:10.1038/s41598-017-15533-z

Cited by 30 publications

(17 citation statements)

References 38 publications

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“…A significant negative association was found in the DBP group for the T4 level, as well as in the BPA group. In a study on rats by Wu et al (2017) the decrease in the T3 and T4 levels was demonstrated after five weeks of oral exposure to the same dose of DBP (50 mg/kg/day) [39]. Conversely to our results, the increase in the T4 level was noted in a study in which rats were orally treated with a slightly higher dose of BPA than in our experiment (40 mg/kg b.w.)…”

Section: Thyroid Hormonescontrasting

confidence: 93%

“…On the other hand, our results have demonstrated significantly increased levels of T4 in the MIX group when compared to the control with mixture showing unexpected opposite pattern to the effect of single substances. Similar results were observed in a study in which rats were given the same DBP dose in combination with thyroglobulin immunization [39]. In this study, lower T3 and T4 levels were demonstrated in groups receiving only DBP, while a mixture of DBP and thyroglobulin expressed an opposite effect, a significant increase in these hormones.…”

Section: Thyroid Hormonessupporting

confidence: 89%

“…This study has demonstrated the increased inflammatory factors (IL-1β and TNF-α) and concluded that the inflammation may play a regulatory role in lipid metabolic disorders induced by DEHP [52]. Furthermore, a study on rats reported a high correlation between the concentration of anti-thyroid peroxidase antibodies and the degree of lymphocytic infiltration of the thyroid gland after the five weeks of DBP exposure at 5 and 50 mg/kg b.w./day doses [39,60].…”

Section: Inflammationmentioning

confidence: 71%

“…Moreover, recent interests are being directed to the effects of these substances on the thyroid tissue and thyroid hormone regulation, linking the changes in thyroid function with the consequential adverse reproductive health [35,36]. To investigate the effects of phthalates on the thyroid, in vivo rodent studies have been conducted to reveal the decrease in thyroid hormones after oral exposure to DEHP [35,37,38], DBP [39], and BPA [40,41]. This is in accordance with the human biomonitoring study from the national health and nutrition examination survey (NHANES, 2007(NHANES, -2008, which included 1346 adults (ages ≥20 years) and 329 adolescents (ages 12-19 years).…”

Section: Introductionmentioning

confidence: 99%

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Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.

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Section: Thyroid Hormonescontrasting

confidence: 93%

Section: Thyroid Hormonessupporting

confidence: 89%

Section: Inflammationmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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“…While there are no data regarding phthalate exposure and RA development, this group of chemicals has been reported to affect other autoimmune diseases. In mice, exposure to dibutyl phthalate aggravated autoimmune thyroid disease andcomparable to our results-induced an increased release of the pro-inflammatory cytokines IL-1β, IL-6, and IL-17 (34,35).…”

Section: Discussionsupporting

confidence: 86%

Phthalate Exposure During the Prenatal and Lactational Period Increases the Susceptibility to Rheumatoid Arthritis in Mice

et al. 2020

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The prenatal and early postnatal period is highly sensitive to environmental exposures that may interfere with the developmental programming of the immune system leading to an altered disease risk in later life. To clarify the role of early influences in activation or exacerbation of autoimmune diseases like rheumatoid arthritis (RA) we investigated the effect of maternal exposure during the prenatal and lactational period of DBA/1 mice to the plasticizer benzyl butyl phthalate (BBP) on the development of RA in the offspring. Using a mild collagen-induced arthritis (CIA) model, maternal BBP-exposure increased both the prevalence and the severity of RA in the progeny compared to un-exposed dams. Additionally, maternal BBP exposure led to elevated serum IgG 1 and IgG 2a level in the offspring and increased the IFN-γ and IL-17 release from collagen-re-stimulated spleen cells. Transcriptome analysis of splenocytes isolated from 3-week-old pups before RA-induction revealed considerable changes in gene expression in the offspring from BBP-exposed dams. Among them were regulator of G-protein signaling 1 (rgs1), interleukin-7 receptor (il-7r) and CXC chemokine 4 (cxcr4), all genes that have previously been described as associated with RA pathology. In summary, our results demonstrate that perinatal exposure to BBP increases the susceptibility of the offspring to RA, probably via a phthalate-induced disturbed regulation of RA-relevant genes or signaling pathways.

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Phthalates and type 1 diabetes: is there any link?

Castro-Correia

Correia-Sá

Norberto

et al. 2018

Environ Sci Pollut Res

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Phthalates are a group of chemical compounds used as plasticizers in the manufacture of plastic materials. They can be present in many commonly used products. There seems to be a relationship between exposure to phthalates and the occurrence of metabolic dysfunctions, such as a decrease in glucose tolerance, oxidative stress, loss of beta cells, and a decrease in insulin synthesis. As beta cells play a key role in the onset of type 1 diabetes mellitus (T1DM), we sought to investigate the relationship between exposure to phthalates and the diagnosis of T1DM in prepubertal children. Design concentrations of phthalate metabolites were compared in the urine of a population of prepubertal children with new-onset diabetes, patients with T1DM diagnosed more than 6 months previously, and healthy control children. Although the concentrations of DBP and DiBP metabolites were statistically identical in the new-onset diabetes, diabetes, and control groups, there was a clear trend for higher levels of DiBP metabolites in the children with new-onset diabetes. In our sample, there was a trend for higher levels of DiBP metabolites in children with new-onset diabetes.

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Oral exposure to dibutyl phthalate exacerbates chronic lymphocytic thyroiditis through oxidative stress in female Wistar rats

Cited by 30 publications

References 38 publications

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Phthalate Exposure During the Prenatal and Lactational Period Increases the Susceptibility to Rheumatoid Arthritis in Mice

Phthalates and type 1 diabetes: is there any link?

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