Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice

Li, Xiang; Ohgami, Nobutaka; Omata, Yasuhiro; Yajima, Ichiro; Iida, Machiko; Oshino, Reina; Ohnuma, S.; Ahsan, Nazmul; Akhand, Anwarul A.; Kato, Masashi

doi:10.1038/s41598-017-06096-0

Cited by 15 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neither randomization nor blinding investigation were used in this animal study. In brief, we exposed mice (n = 7) to 22.5 mg/L of sodium arsenite (NaAsO 2 , Sigma-Aldrich) dissolved in distilled water for 2 months via drinking water and changed the drinking water every week as previously described [ 16 ]. The exposure dose was based on the As exposure for mice at 10 and 100 ppm via drinking water in a previous study [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…In our previous study using pure tone audiometry (PTA), an association of oral exposure to As via drinking water with hearing loss in young people was shown by multivariate analysis with adjustments for confounders including age, smoking, sex and BMI [ 16 ]. However, multivariate analysis has not been performed to demonstrate the association of As levels in nails with hearing loss in humans, although age and smoking are known to be strong factors affecting hearing levels in humans [ 14 , 17 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Exposure of guniea pigs to As at 200 mg/L via intraperitoneal injection for 2 months resulted in morphological impairments of the inner ear [ 24 ]. Our previous study has showed that exposure of young mice to As via drinking water caused accumulation of As in inner ears, resulting in hearing loss [ 16 ]. However, it is not clear whether there is a correlation between As levels in inner ears and nails in mice.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Arsenic level in toenails is associated with hearing loss in humans

Ohgami

Yajima

et al. 2018

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Arsenic (As) pollution in drinking water is a worldwide health risk for humans. We previously showed hearing loss in young people who live in areas of As-polluted drinking water and in young mice orally treated with As. In this study, we epidemiologically examined associations between As levels in toenails and hearing in 145 Bangladeshi aged 12–55 years in 2014. Levels of As in toenails, but not those in urine, were shown to be significantly correlated with hearing loss at 4 kHz [odds ratio (OR) = 4.27; 95% confidence interval (CI): 1.51, 12.05], 8 kHz (OR = 3.91; 95% CI: 1.47, 10.38) and 12 kHz (OR = 4.15; 95% CI: 1.55, 11.09) by multivariate analysis with adjustments for age, sex, smoking and BMI. Our experimental study further showed a significant association between As levels in inner ears and nails (r = 0.8113, p = 0.0014) in mice orally exposed to As, suggesting that As level in nails is a suitable index to assess As level in inner ears. Taken together, the results of our study suggest that As level in nails could be a convenient and non-invasive biomarker for As-mediated hearing loss in humans.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Arsenic level in toenails is associated with hearing loss in humans

Ohgami

Yajima

et al. 2018

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our participants, contaminated drinking water was less of a problem than direct exposure of the ears, eyes, mouth, or nose to air containing high concentrations of arsenic. Furthermore, previous studies revealed that chronic arsenic exposure caused eye diseases (See et al 2007 ; Sinczuk-Walczak et al 2010 ; Chen 2014 ), hearing impairment (Kesici et al 2016 ; Li et al 2017 ), oral cavity lesions (Sarwar et al 2010 ; Syed et al 2013 ), olfactory dysfunction (Ishinishi et al 1977 ; Mukherjee et al 2014 ), and memory impairment (Tyler and Allan 2014 ). Arsenic levels in some of our participants’ hair were found to be high when the Toroku Medical Examination was first administered (10 years after exposure ended).…”

Section: Discussionmentioning

confidence: 99%

Clinical Symptoms, Neurological Signs, and Electrophysiological Findings in Surviving Residents with Probable Arsenic Exposure in Toroku, Japan

Ishii

Mochizuki

Ebihara

et al. 2018

Arch Environ Contam Toxicol

View full text Add to dashboard Cite

Chronic arsenic intoxication is known to cause multisystem impairment and is still a major threat to public health in many countries. In Toroku, a small village in Japan, arsenic mines operated from 1920 to 1962, and residents suffered serious sequelae of arsenic intoxication. We have performed annual medical examinations of these residents since 1974, allowing us to characterize participants’ long-term health following their last exposure to arsenic. The participants could not be described as having “chronic arsenic intoxication,” because their blood arsenic levels were not measured. In this study, we defined them as having “probable arsenic intoxication.” Symptoms frequently involved the sensory nervous system, skin, and upper respiratory system (89.1–97.8%). In an analysis of neurological findings, sensory neuropathy was common, and more than half of the participants complained of hearing impairment. Longitudinal assessment with neurological examinations and nerve conduction studies revealed that sensory dysfunction gradually worsened, even after exposure cessation. However, we could not conclude that arsenic caused the long-term decline of sensory function due to a lack of comparisons with age-matched healthy controls. This is the first study to characterize the longitudinal sequelae after probable arsenic exposure. Our study will be helpful to assess the prognosis of patients worldwide who still suffer from chronic arsenic intoxication.

show abstract

“…8 Oxidative stress status is an imbalance between the production of active oxygen species and the ability of a biological system to eliminate these compounds, which results in damage to the biological system and consequently organ dysfunction. 8,9 Oxidative stress is one of the ways of the main causes of renal failure. 10 It has been shown that an increase in free radical production causes loss of function in the kidneys.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Changes and Antioxidant Enzymes Status in Oxidative Stress Induction Using Sodium arsenite in Rats

Nozohour

Jalilzadeh-Amin

2019

J Apple Biotechnol Rep

View full text Add to dashboard Cite

Introduction: Arsenic toxicity has posed troublesome health concerns in the world and many of the toxic effects of arsenic are related to its effect on oxidative stress. The aim of the present study is to evaluate histopathological and antioxidant enzymes changes in oxidative stress status induced by sodium arsenite in rats. Materials and Methods: All experiments were carried out in male Wistar rats. Animal were divided into 2 groups of eight animals in each: Rats consumed distilled water (control group). Group 2: Rats consumed a solution of sodium arsenite (100 ppm) daily (arsenic group). At the end of day 28 arsenic exposure, the enzyme level in rat liver and kidney tissues was measured using the assay kits. The remaining liver, kidney, and heart tissue were fixed in 10% neutral-buffered formalin and used for histological observation. Results: The results showed a significant decrease in values of glutathione peroxidase (GPx), superoxide dismutase (SOD), total antioxidant capacity (TAC) and catalase (CAT) in serum and tissue in kidney and liver rat (P < 0.05). But, malondialdehyde (MDA) levels were increased significantly (P < 0.05). Arsenic caused severe degenerative changes in tubular cells and acute tubular necrosis, hepatocyte cell degeneration, severe hemorrhage, and infiltration and formation of Kupffer cells nodules, fragmentation, and degeneration of muscle fibers with pyknotic nuclei in heart tissue. Conclusions: The finding of the present study revealed that the administration of Sodium arsenite caused significant oxidative stress, decreased antioxidant enzymes activity and severe tissue damage.

show abstract

Oral exposure to arsenic causes hearing loss in young people aged 12–29 years and in young mice

Cited by 15 publications

References 26 publications

Arsenic level in toenails is associated with hearing loss in humans

Arsenic level in toenails is associated with hearing loss in humans

Clinical Symptoms, Neurological Signs, and Electrophysiological Findings in Surviving Residents with Probable Arsenic Exposure in Toroku, Japan

Histopathological Changes and Antioxidant Enzymes Status in Oxidative Stress Induction Using Sodium arsenite in Rats

Contact Info

Product

Resources

About