Oral epithelial-derived mediators suppress RANKL expression in human mandibular-derived bone cells
Pakchisa Khonsuphap
Abstract:Prostaglandin E2 (PGE2) accumulates in inflamed periodontal tissue and induces RANKL/RANK/OPG signaling associated with bone resorption. Although oral epithelial cells maintain tissue homeostasis, the role of oral epithelial cells in RANKL regulation remains unknown. To investigate the epithelial mediators involved in regulating RANKL expression in PGE2-stimulated human mandibular bone-derived cells (HMBCs) and RANKL driven osteoclastic-cell activity. HMBCs were stimulated with 0.1 μM PGE2 for 24 h to increase… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.