Oral drug reactions

Tack, D. Alan; Rogers, Roy S.

doi:10.1046/j.1529-8019.2002.01532.x

Cited by 16 publications

(18 citation statements)

References 50 publications

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“…Many adverse effects are attributed to anti-metabolic drugs [6,15]. Del Pozo et al [16] described skin ulcers as consequence of methotrexate toxicity.…”

Section: Discussionmentioning

confidence: 99%

Methotrexate delayed wound healing of a pyogenic granuloma in a child with juvenile idiopathic arthritis.

Schwarzmeier

Kitakawa

Rosa

et al. 2019

BDS

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A nine-year-old girl with of juvenile idiopathic arthritis (JIA) in use of methotrexate complained of a self-bleeding ulcerated lesion exhibiting a red surface in the lower lip. Pyogenic granuloma was confirmed by histopathological analysis. After the 7th and 15th days, the lip where biopsy had been done exhibited a deficient healing. The case was discussed with the physician for temporary suspension of methotrexate. Complete wound healing of the biopsied site occurred after temporary interruption of the medication. Wound healing after methotrexate temporary suspension allowed concluding that the drug delayed surgical wound healing was a consequence of drug cytotoxicity.

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“…Many adverse effects are attributed to anti-metabolic drugs [6,15]. Del Pozo et al [16] described skin ulcers as consequence of methotrexate toxicity.…”

Section: Discussionmentioning

confidence: 99%

Methotrexate delayed wound healing of a pyogenic granuloma in a child with juvenile idiopathic arthritis.

Schwarzmeier

Kitakawa

Rosa

et al. 2019

BDS

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“…It is important to identify which drug can be suspected because their discontinuation is the definitive treatment of gingival bleeding. The patient may have significant discomfort prior to the resolution of the reaction that requires palliative measures (Tack & Rogers, ).…”

Section: Introductionmentioning

confidence: 99%

“…Drugs can also be a cause of gingival bleeding, through an effect on vascular permeability, coagulation or platelet function or number (Tack & Rogers, 2002;Little et al, 2008;Aster, Curtis, McFarland, & Bougie, 2009). It is important to identify which drug can be suspected because their discontinuation is the definitive treatment of gingival bleeding.…”

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confidence: 99%

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Gingival bleeding, a possible “serious” adverse drug reaction: An observational study in the French PharmacoVigilance Database

Bondon‐Guitton

Mourgues

Rousseau

et al. 2017

J Clinic Periodontology

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Gingival bleeding can be an adverse drug reaction, often "serious" and rarely fatal. Patients older than 50 years and women are particularly at risk. Among drugs known to increase the risk of gingival bleeding, the most frequently involved were fluindione, furosemide, paracetamol, amiodarone, amoxicillin, paroxetine or ketoprofen. We also identified signal for drugs not usually known to be involved in bleeding, like zolpidem, enalapril or ramipril.

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“…However, there is a big gap when we observe the low scientific productivity of oral lesions on soft tissue, affecting the oral health of pediatric patients 4,[6][7][8] . It is essential to the affirmation of the high incidence of these lesions in children; and the certainty that, in most cases, these injuries do not get a quick diagnosis that enables a ready treatment 9,10 . There are many myths, mysteries and superstitions surrounding families and professionals with respect to these pathologies.…”

Section: Introductionmentioning

confidence: 99%

Lesões bucais na infância: revisão sistemática de interesse da fonoaudiologia

Matos

Sá²,

Pereira³

et al. 2016

Rev. CEFAC

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The background of this study is speech therapists, physicians and dentists that are professionals that in their professional actions, conduct intraoral examinations on their patients. Many children, from birth, have affection for oral lesions that can bring temporary inconvenience to daily life. The purpose is to provide health professionals a systematic review about the most common oral lesions in children and the interests of speech therapy. Health professionals should always seek to increase their knowledge by improving health care for their patients. Keywords: Oral Health; Stomatitis; Mucocele RESUMO Este estudo tem como tema, fonoaudiólogos, médicos e dentistas que são profissionais que, frequentemente, em suas ações profissionais, realizam exames intrabucais em seus pacientes. Muitas crianças, desde seu nascimento, apresentam o acometimento por lesões bucais que podem trazer transtornos temporários ao cotidiano. O objetivo é apresentar aos profissionais de saúde uma revisão sistemática acerca das lesões bucais mais frequentes em crianças e de interesse da fonoaudiologia. Os profissionais de saúde devem buscar sempre aumentar seus conhecimentos melhorando a atenção à saúde de seus pacientes.

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Oral drug reactions

Cited by 16 publications

References 50 publications

Methotrexate delayed wound healing of a pyogenic granuloma in a child with juvenile idiopathic arthritis.

Methotrexate delayed wound healing of a pyogenic granuloma in a child with juvenile idiopathic arthritis.

Gingival bleeding, a possible “serious” adverse drug reaction: An observational study in the French PharmacoVigilance Database

Lesões bucais na infância: revisão sistemática de interesse da fonoaudiologia

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