Oral disposition index as a predictor of changes in glucose tolerance status over time

Abstract

Diabetes (to include epidemiology, pathophysiology) Regressors(n = 45) Non-regressors (n = 56) PAge (years) 57.1 ± 11.6 53.1 ± 11.2 0.084 Female -n (%) 32 (71.1) 39 (69.9) 0.874 BMI (kg/m 2 ) 33 ± 6.1 36.5 ± 6.8 0.725Waist circumference (cm) 105.9 ± 13.9 108.3 ± 12.7 0.369 Fasting glucose (mg/dL) 106 (100 -118.5) 108 (97.5 -115.5) 0.128 2-hour glucose (mg/dL) 202 (161.5 -240.5) 170 (157 -219.5) 0.184 A1c (%) 6.1 (5.7 -6.6) 6.1 (5.7 -6.9) 0.862 Time of follow-up (months) 26 ( (cm) 96 ± 14.8 103.6 ± 12.7 105.4 ± 13.2 0.005105.4 (63.8 -196.6) 80.6 (55.1 -120.5) 68.4 (45.5 -91.9) -HOMA-IR (%) 1.9 (1 -3.1) 2.5 (1.7 -3.9) 3.5 (2.6 -5.4) - Therefore, the objective is to assess the validity of DIo in our population and to determine whether DIo predicts regression to a better GTS. References• A total of 47.5% of patients regressed to a better glucose tolerance status while participating in a program with multiple interventions for the treatment of hyperglycemia.The Oral Disposition Index in our population was able to predict the regression to a better glucose tolerance status. It was proved to be reproducible and could be applied for DM research in the Brazilian population. Our outpatient clinic presents regression and progression rates of the glucose tolerance statuts compatible with epidemiologic studies.• Longitudinal study• At first evaluation, 179 patients from an outpatient clinic were submitted to a 75g-OGTT and classified according to different degrees of glucose tolerance based on ADA criteria.• Patients with prediabetes (PDM) and DM had their data recollected, and patients were classified as regressors and non-regressors to a better GTS.• Insulin sensitivity was estimated as 1/fasting insulin and β-cell function as the ratio of the change in insulin to the change in glucose from 0 to 30 (∆I0-30/∆G0-30). The DIo was calculated as (∆I0-30/∆G0-30 x 1/fasting insulin).• Data are presented as mean ± standard deviation (SD), median (P25-P75), unless otherwise specified. A two-sided P value <0.05 was considered significant. OBJECTIVES METHODS RESULTS CONCLUSIONS ORAL DISPOSITION INDEX AS A PREDICTOR OF CHANGES IN GLUCOSE TOLERANCE STATUS OVER TIME SUBJECTS'S CHARACTERISTICS AT FIRST EVALUATION BASAL AND FINAL CHARACTERISTICS OF THE RE-EVALUATED SUBJECTS