Oral disintegration tablets of stavudine for HIV management: A new technological approach

Abstract

Stavudine oral disintegration tablets were formulated to minimize the bitter taste and to reduce the first-pass hepatic metabolism. The various precompression parameters like the angle of repose, bulk density, compressibility index and Hausner's ratio were determined for the powder blend. In this study, 14 formulations of stavudine oral disintegration tablet were prepared by direct compression method. The tablets were evaluated for weight variation, percentage friability, disintegration time, hardness, wetting time and water absorption ratio. The in vitro dissolution study results of the batch S1 (stavudine+crospovidone+sodium starch glycollate) are encouraging as highest dissolution rate (99.2% in 100 min) and lowest time of disintegration (56 s) was achieved. The in vivo drug release studies were carried out in rabbits and the relative bioavailability of formulation S1 was found to be 2.83 times greater than that of conventional tablets.

Preparation and Evaluation of Rosuvastatin Calcium Nanosuspension and Solid Dispersion Tablets by Wet Granulation and Direct Compression Techniques using Tamarind Gum as a Binder

“…The angle of repose values of RC and the powder blends of NRC and DRC were determined by the funnel method (Reposogram) [1] . Accurately weighed powder blend was taken in a funnel and the powder was allowed to flow through the funnel freely onto the surface.…”

“…Loose bulk density (LBD) and tapped bulk density (TBD) of RC and the powder blends of NRC and DRC were determined using a bulk density apparatus (Electrolab, India) [1] . Accurately weighed 5 g of the powdered blend was placed in a 100 ml graduated measuring cylinder and the initial volume was observed.…”

“…The disintegration time of the tablet was measured as per IP using a disintegration apparatus [1] . Each of the 6 tablets was placed in the six tubes and immersed in water bath maintained at 37°.…”

“…In vitro drug release of the samples was carried out according to the USP dissolution method [1] (type II dissolution apparatus, paddle type). The dissolution medium (900 ml of phosphate buffer at pH 6.8) was placed in the dissolution basket at a temperature of 37±0.5° and rpm of 50.…”

“…Among the various routes of delivery available, the oral route is the most preferred route of administration, with advantages like high patient compliance and better pharmacokinetic profile [1] . Tablets constitute a major portion of drug delivery systems that are currently available in the market.…”