Oral disintegrating desmopressin tablet is effective for partial congenital          nephrogenic diabetes insipidus with &lt;i&gt;AVPR2&lt;/i&gt; mutation: a case          report

Ikegawa, Kento; Hachiya, Rumi; Akiba, Kazuhisa; Hasegawa, Yukihiro

doi:10.1297/cpe.2021-0032

Cited by 1 publication

(2 citation statements)

References 20 publications

(31 reference statements)

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“…DDAVP does not inherently address the pathogenesis of NDI. However, contrary to expectations, several reports have suggested that DDAVP can be effective in specific cases of NDI (16)(17)(18)(19)(20)(21)(22)(23)(24). Fujimoto et al documented that 21.7% of patients with NDI received DDAVP, with a response rate of 33.3% for acquired NDI (16).…”

Section: Discussionmentioning

confidence: 93%

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Lithium-induced Nephrogenic Diabetes Insipidus with Efficacy of Desmopressin in Combination with Thiazide Diuretics and Non-steroidal Anti-inflammatory Drugs: A Case Report with a Review of the Literature

Jinnouchi,

Yoshimoto,

Ogino

et al. 2024

Intern. Med.

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Nephrogenic diabetes insipidus (NDI) is characterized by excessive urination and an inability to concentrate urine. Lithium is the most common cause of acquired NDI. Treatment typically involves thiazide diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs). However, the efficacy of desmopressin in NDI remains unclear. We herein report a case of lithium-induced NDI in a 71-year-old woman with lithium-induced NDI. Thiazide diuretics and NSAIDs reduced the urine output by approximately 40% compared to pretreatment, while the addition of desmopressin reduced it by approximately 70%. This case suggests that desmopressin can be a viable treatment option for lithium-induced NDI.

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Section: Discussionmentioning

confidence: 93%

“…However, how often DDAVP reduces the urine output in lithium-induced NDI is unclear. Nevertheless, reports have indicated the efficacy of high doses of DDAVP in the treatment of NDI (17)(18)(19)(20)(21)(22)(23)(24). Among these reports, only four cases of lithium-induced NDI in response to DDAVP have been documented (Table 4).…”

Section: Discussionmentioning

confidence: 99%