Oral discomfort at menopause

Wardrop, Robert; Hailes, Jean; Burger, Henry G.; Reade, Peter C.

doi:10.1016/0030-4220(89)90269-7

Cited by 161 publications

(88 citation statements)

References 27 publications

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“…Furthermore, menopausal women on hormone replacement therapy showed improvements in a number of oral health-related complaints, such as dry mouth, glossalgia, periodontal disease, oral stickiness, and dysgeusia. (44,45) In this study, a significant effect was observed in the amount of saliva; oxidative stress levels showed a decreasing trend, and the interaction between isoflavone intake and the presence of SS was confirmed regarding the items ”dry mouth” and ”need water when eating” by the intake of 25 mg of soybean isoflavones (23 mg as aglycone) per day for two months in 15 subjects who recognized dry mouth symptoms. Therefore, the intake of isoflavones was thought to be effective in the relief of dry mouth that occurs in menopause and SS and of the general physical complaints of SS-affected individuals who presented with serious dry mouth.…”

Section: Discussionsupporting

confidence: 56%

“…(41) Menopausal women with rapidly declining estrogen levels were reported to show decreased salivary secretion and intraoral discomfort. (42–44) In addition, considering reports that ERs are found in the salivary glands and that estrogen itself is secreted in the saliva, decreasing estrogen levels are assumed to affect salivary secretion. Furthermore, menopausal women on hormone replacement therapy showed improvements in a number of oral health-related complaints, such as dry mouth, glossalgia, periodontal disease, oral stickiness, and dysgeusia.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic effects of isoflavones on impaired salivary secretion

Ryo

Takahashi

Tamaki³

et al. 2014

J. Clin. Biochem. Nutr.

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Dry mouth, which is characterized by decreased salivation, has a number of causes; the involvement of estrogen has been suggested as symptoms typically develop in middle-aged females. However, there is a lack of consensus regarding the treatment of this condition. Soy isoflavones, a subgroup of flavonoids, are abundantly found in the soy germ. They are thought to exert a number of effects by specifically binding to estrogen receptors due to their structural similarity to estrogen. Recently, soy isoflavones have been found to exert antioxidant effects, ameliorating disorders caused by reactive oxygen/free radicals. Based on these observations, the effects of soybean isoflavones on impaired salivary secretion were studied in patients with dry mouth. Soy isoflavone aglycones were administered at 25 mg per day to 15 subjects with an average age of 67.9 ± 8.0 years for 2 months, and salivary secretion was analyzed. The results showed a significant improvement based on the saliva flow rate and self-completed questionnaire, thus suggesting the usefulness of isoflavones in improving the symptoms of salivary gland hypofunction.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of isoflavones on impaired salivary secretion

Ryo

Takahashi

Tamaki³

et al. 2014

J. Clin. Biochem. Nutr.

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“…Some controversial studies exist on the effect of the use of HT on the occurrence of oral symptoms, such as the sensations of burning mouth, dry mouth, and temporomandibular joint disorders [1][2][3][4]. We have reported that the sensations of painful mouth or dry mouth were not associated with the use of HT in menopause age women in a questionnaire study on 3,173 women [5].…”

Section: Introductionmentioning

confidence: 91%

Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

et al. 2011

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This study aims to investigate salivary flow and biochemical constituents of menopausal-age women with the hypothesis that women using hormone therapy (HT) might present better saliva values than non-users. Two hundred HT users and 200 non-users were selected at random from a cohort study of 3,173 peri- and postmenopausal women and invited to a 2-year clinical follow-up study. Clinical examination with saliva sampling was made at baseline and 2 years later. Salivary total protein, albumin, and immunoglobulin (Ig) concentrations were analyzed. Final material included 106 consistent HT users and 55 non-users. Backward logistic regression analysis was made to determine the risk factors for higher or lower than medium salivary protein values. No difference was seen in salivary flow rate, total protein, and IgA values between baseline and follow-up measurements or between the groups. Albumin, IgG, and IgM concentrations were significantly lower in the 2-year samples of the HT group when compared with baseline. IgA and IgM values were higher in the non-HT 2-year samples when compared with the corresponding HT samples. The only significant explanatory factor for higher than median salivary albumin concentration was the number of teeth both at baseline and 2 years later. HT possibly improved epithelial integrity since the concentrations of serum components albumin, IgG, and IgM decreased during the follow-up. HT as such does not seem to affect saliva, although it may modify it. The clinical relevance of these results needs to be assessed in future studies.

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“…Aktuelle Über-sichtsarbeiten beschreiben besonders häufig klinische Manifestationen wie eine Reduktion des Speichelflusses, Mundtrockenheit, eine Reduktion der epithelialen Keratinisierung, Rötungen oder Blutungen beim Putzen oder Sondieren [2,5,7,8,11,[13][14][15][16]18]. » Peri-und postmenopausale Patientinnen berichten häufiger über orale Missempfindungen…”

Section: Häufige Beschwerdebilder In Der Zahnarztpraxisunclassified

Menopause und Mundgesundheit

Bruckmann

2016

Gynäkologische Endokrinologie

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Dass im Klimakterium auch orale Probleme häufiger auftreten, ist zu wenig bekannt. Zu Mundtrockenheit, Schleimhautschmerzen und Zungenbrennen kann es kommen, da auch die orale Mukosa Hormonrezeptoren aufweist. Praktische Ärzte, Gynäko-logen und Zahnärzte sollten diese Probleme in der Kommunikation offen ansprechen. Von Patientinnen werden sie häufig nicht mit den Wechseljahren in Zusammenhang gebracht und daher auch oft nicht angegeben.

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Oral discomfort at menopause

Cited by 161 publications

References 27 publications

Therapeutic effects of isoflavones on impaired salivary secretion

Therapeutic effects of isoflavones on impaired salivary secretion

Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

Menopause und Mundgesundheit

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