Oral Dextromethorphan Reduces Perioperative Analgesic Administration in Children Undergoing Tympanomastoid Surgery

Hasan, Rashed A.; Kartush, Jack M.; Thomas, John D.; Sigler, Diana

doi:10.1016/j.otohns.2004.06.709

Cited by 7 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirty clinical studies were identified (6–35). Two studies were subsequently excluded because of either a lack of a placebo group (15) or a lack of description of randomization (7) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 1629 patients was studied, 906 of whom received DM. Ten studies compared parenteral DM (6, 8, 10, 13, 16, 17, 22, 28, 33, 34) and 18 studies compared oral DM (9, 11, 12, 14, 18–21, 23–27, 29–32, 35) with placebo. The range of numbers of patients included in the studies was 35–120.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies scored two, six studies scored three, eight studies scored four and eight studies scored five. Three studies were conducted in children (12, 25, 31). Pain intensity was assessed using VAS in all studies except two, which used the faces pain scale (25) and the four‐point verbal rating scale (19).…”

Section: Resultsmentioning

confidence: 99%

“…However, a number of studies only presented data on the worst experienced VAS score (13, 16, 17, 22, 28, 35), and data on the mean VAS scores during the early and late post‐operative periods were therefore not extractable in these studies. VAS scores and supplemental analgesic consumption had to be extrapolated from presented graphs in 14 studies (9–11, 18, 20, 23, 24, 26, 27, 30–34) and six studies (11, 20, 21, 24, 30, 32), respectively. Details of the included studies are shown in Tables 1–4.…”

Section: Resultsmentioning

confidence: 99%

“…Clinical studies in volunteers (4, 5) have demonstrated anti‐hyperalgesic effects of DM. Several clinical studies (6–35) have been conducted in post‐operative patients, but consensus on whether DM offers clinically relevant post‐operative pain relief is still lacking.…”

mentioning

confidence: 99%

See 4 more Smart Citations

A qualitative systematic review of peri‐operative dextromethorphan in post‐operative pain

Duedahl¹,

Rømsing²,

Møiniche

et al. 2005

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Background: The N-methyl-D-aspartate (NMDA) receptor antagonist, dextromethorphan (DM), has received interest as an adjunctive agent in post-operative pain management. Clinical trials have been contradictory. This systematic review aims to evaluate the available literature examining the analgesic efficacy of DM in post-operative patients. Methods: Twenty-eight randomized, double-blind, clinical studies, with 40 comparisons, including a variety of dosing regimens comparing DM treatment with placebo, were included. Meta-analysis was intended but deemed to be inappropriate because of the substantial difference in methodology and reporting between trials. The outcome measures (pain scores at rest, time to first analgesic request and supplemental analgesic consumption) were evaluated qualitatively by significant difference (P < 0.05) as reported in the original investigations. Results: DM did not reduce the post-operative pain score with a clinically significant magnitude. The time to first analgesic request was significantly prolonged in most comparisons with DM. Significant decreases in supplemental opioid consumption were observed in the majority of parenteral DM studies and in

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%