Oral delivery of vancomycin by tetraether lipid liposomes

Uhl, Philipp; Pantze, Silvia; Storck, Philip; Parmentier, Johannes; Witzigmann, Dominik; Hofhaus, Götz; Huwyler, Jörg; Mier, Walter; Fricker, Gert

doi:10.1016/j.ejps.2017.07.013

Cited by 74 publications

(40 citation statements)

References 32 publications

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“…In an attempt to enhance the stabilization of orally administered peptide antibiotics, vancomycin was encapsulated within liposomes containing specific tetra ether lipid. The results of in vivo study on Wistar rats expressed a strong enhancement in the oral bioavailability of vancomycin using the liposomal formulation (4.82 ± 0.56%), where the given oral dose of vancomycin reached the blood after one hour, which is considered a very good achievement for the oral administration of peptide antibiotics [41]. Further, administrations of either dicloxacillin-loaded liposomes or dicloxacillin-loaded chitosan-coated liposomes were evaluated against MRSA infections.…”

Section: -Better Protection and Enhanced Antibiotics Biodistributionmentioning

confidence: 99%

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application.

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Section: -Better Protection and Enhanced Antibiotics Biodistributionmentioning

confidence: 99%

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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“…Some of the presented compounds have already been tested on vancomycin-intermediate S. aureus strains, with promising results (Blaskovich et al 2018;Yarlagadda et al 2014Yarlagadda et al , 2016Guan et al 2019). However, vancomycin is still considered to be the gold standard for the therapy of susceptible representatives of this species (Uhl et al 2017). Furthermore, it was already approved for therapeutic treatment of infections with Clostridium difficile (Bartlett 2008).…”

Section: Counteracting Strategiesmentioning

confidence: 99%

Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria

et al. 2020

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The emergence of multidrug-resistant bacteria demands innovations in the development of new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered as the “last resort” treatment of severe infections caused by Gram-positive bacteria. Since the discovery of the first vancomycin-resistant enterococci strains in the late 1980s, the number of resistances has been steadily rising, with often life-threatening consequences. As an alternative to the generation of completely new substances, novel approaches focus on structural modifications of established antibiotics such as vancomycin to overcome these resistances. Here, we provide an overview of several promising modifications of vancomycin to restore its efficacy against vancomycin-resistant enterococci.

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“…It is critical to accurately characterize liposomes and drug-liposome interactions as biophysical properties of liposomes are known to influence biological activity, biodistribution, and toxicity. Among the available techniques (Dynamic Light Scattering (DLS), Size Exclusion Chromatography (SEC), Atomic Force Microscopy (AFM), and cryo-EM), cryo-EM is the most precise and direct method to determine liposome lamellarity, size, shape and ultrastructure, which may reveal clues to mechanism of action toward the clinical endpoints of efficacy and toxicity (Aissaoui et al, 2011;Al-Ahmady et al, 2016;Baxa, 2018;Bonnaud et al, 2013;Crawford et al, 2011;De Carlo et al, 2004;Lepault et al, 1985;Uhl et al, 2017;Uhl et al, 2016;Zhang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cryo-EM sample preparation method for extremely low concentration liposomes

Tonggu

Wang

2018

Preprint

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Liposomes are widely used as delivery systems in pharmaceutical, cosmetics and food industries, as well as a system for structural and functional study of membrane proteins. To accurately characterize liposomes, cryo-Electron Microscopy (cryo-EM) has been employed as it is the most precise and direct method to determine liposome lamellarity, size, shape and ultrastructure. However, its use is limited by the number of liposomes that can be trapped in the thin layer of ice that spans holes in the perforated carbon film on EM grids. We report a long-incubation method for increasing the density of liposomes in holes. By increasing the incubation time, high liposome density was achieved even with extremely dilute (in the nanomolar range) liposome solutions. This long-incubation method has been successfully employed to study the structure of an ion channel reconstituted into liposomes. This method will also be useful for preparing other biological macromolecules / assemblies for structural studies using cryo-EM.

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Oral delivery of vancomycin by tetraether lipid liposomes

Cited by 74 publications

References 32 publications

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria

Cryo-EM sample preparation method for extremely low concentration liposomes

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