Oral Delivery of Insulin: Novel Approaches

Elsayed, Amani

doi:10.5772/52265

Cited by 3 publications

(1 citation statement)

References 112 publications

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“…Introducing therapeutic substances into the body without the support of nanotechnological carriers poses specific challenges and drawbacks. Traditional methods of drug delivery often result in low bioavailability and uncontrolled release of substances, leading to toxicity and side effects on normal cells and tissues [ 22 , 23 ]. Additionally, in the case of anticancer therapy, conventional drugs often damage healthy cells, generating undesirable side effects [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Drabczyk,

Kudłacik-Kramarczyk,

Jamroży

et al. 2024

IJMS

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Nano-sized biomaterials are innovative drug carriers with nanometric dimensions. Designed with biocompatibility in mind, they enable precise drug delivery while minimizing side effects. Controlled release of therapeutic substances enhances efficacy, opening new possibilities for treating neurological and oncological diseases. Integrated diagnostic-therapeutic nanosystems allow real-time monitoring of treatment effectiveness, which is crucial for therapy personalization. Utilizing biomaterials as nano-sized carriers in conjunction with drugs represents a promising direction that could revolutionize the field of pharmaceutical therapy. Such carriers represent groundbreaking drug delivery systems on a nanometric scale, designed with biocompatibility in mind, enabling precise drug delivery while minimizing side effects. Using biomaterials in synergy with drugs demonstrates significant potential for a revolutionary impact on pharmaceutical therapy. Conclusions drawn from the review indicate that nano-sized biomaterials constitute an innovative tool that can significantly improve therapy effectiveness and safety, especially in treating neurological and oncological diseases. These findings should guide researchers towards further studies to refine nano-sized biomaterials, assess their effectiveness under various pathological conditions, and explore diagnostic-therapeutic applications. Ultimately, these results underscore the promising nature of nano-sized biomaterials as advanced drug carriers, ushering in a new era in nanomedical therapy.

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Section: Introductionmentioning

confidence: 99%

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Drabczyk,

Kudłacik-Kramarczyk,

Jamroży

et al. 2024

IJMS

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Drug Absorption via the Nasal Route: Opportunities and Challenges

Amponsah

Adams

2023

Nasal Drug Delivery

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Synthesis of Glucose-Sensitive Microcapsules via Layer-by-Layer Assembly for Controlled Insulin Release Applications

Talusan

Baltazar

Usman

et al. 2017

AMM

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Drug delivery systems using polymeric materials have been under intensive investigation and have been reported to show effective drug targeting specificity, lowering system drug toxicity, improving treatment absorption rates, and providing enteric coatings against biochemical degradation. The layer–by–layer (Lbl) assembly of polyelectrolytes through electrostatic interactions can be readily tailored to control the size, structure, and stability of the film and microcapsules. In this study, microcapsules were fabricated by alternately depositing poly (dimethyldiallylammonium chloride) PDDA, glucose oxidase (GOx), and polyacrylic acid (PAA) to form multilayer shells on a MnCO3 template and onto insulin particles by Lbl method. Also, the physical characteristic and release mechanism of thin films incorporating insulin sandwiched between [2(dimethyl amino) ethyl methacrylate] (PDMAEMA), with polymer/GOx layers were compared with the fabricated microcapsules. The synthesized shells have shown stability at pH 4 and become unstable at neutral pH. The fabricated insulin loaded microcapsules and films showed an on–off mechanism in the presence of glucose. Exposure to glucose solutions resulted in the production of gluconic acid; as a result, there was a change in the conformation of the polymer, releasing the embedded insulin. The drug release profiles observed indicates their potential application for the controlled release of insulin.

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Oral Delivery of Insulin: Novel Approaches

Cited by 3 publications

References 112 publications

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Drug Absorption via the Nasal Route: Opportunities and Challenges

Synthesis of Glucose-Sensitive Microcapsules via Layer-by-Layer Assembly for Controlled Insulin Release Applications

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