Oral Delivery of Curcumin Polymeric Nanoparticles Ameliorates CCl4-Induced Subacute Hepatotoxicity in Wistar Rats

Abstract

Curcumin is the major bioactive compound of Curcuma longa, an important medicinal plant used in traditional herbal formulations since ancient times. In the present study, we report that curcumin nanoparticles (ηCur) protects Wistar rats against carbon tetrachloride (CCl4)-induced subacute hepatotoxicity. Nanoparticles of sizes less than 220 nm with spherical shape were prepared using PLGA and PVA respectively as polymer and stabilizer. Test animals were injected via intraperitoneal route with 1 mL/kg CCl4 (8% in olive oil) twice a week over a period of 8 weeks to induce hepatotoxicity. On the days following the CCl4 injection, test animals were orally administered with either curcumin or its equivalent dose of ηCur. Behavioural observation, biochemical analysis of serum and histopathological examination of liver of the experimental animals indicated that ηCur offer significantly higher hepatoprotection compared to curcumin.

Hepatoprotective effects of Curcumin-Mesoporous Silica Nanoparticles on CCl 4 -induced Hepatotoxicity Wistar rats

“…(Girish and Pradhan, 2012;Hismiogullari et al, 2014;Y. Kim et al, 2014;Lee et al, 2017;Marslin et al, 2018;Paolo and Kateri, 2017;Park et al, 2000;Saygili et al, 2016;Singh et al, 2014; 117 Wu et al, 2008;Zhao et al, 2014). Hepatic damage induction using CCl4 it is easily reproducible, and it simulates human liver cirrhosis quite well by the generation of oxidative stress and induces proinflammatory and profibrotic cytokines.…”

“…Curcumin also has been loaded in nanoparticles prepared from PLGA and PVA was given four times a week with CCl4 given two times a week. That curcumin nanoparticles showed a good hepatoprotection effect as AST, ALT, and ALP value was decreased, and no damage was found in liver tissue treated with nano-curcumin (Marslin et al, 2018).…”

“…In several previous studies, C. longa was reported to have a hepatoprotective effect against CCl4 hepatic damage induction (Girish and Pradhan, 2012;Hismiogullari et al, 2014;Lee et al, 2017;Marslin et al, 2018;Paolo and Kateri, 2017;Park et al, 2000;Saygili et al, 2016;Singh et al, 2014;Wu et al, 2008;Zhao et al, 2014). Fermented C. longa is showing a hepatoprotective effect by suppressing oxidative stress caused by CCl4 .…”

Evaluation of In-Vitro Release Kinetic and Mechanisms of Curcumin Loaded-Cockle Shell-Derived Calcium Carbonate Nanoparticles

“…Usually high dose of curcumin is required to overcome such conditions thereby maximizing it's concentration in the blood to be of equal range with the therapeutic blood concentration [12,14]. These setbacks has led to curcumin's major drawbacks as a standard therapeutic agent [15,16]. However, curcumin being safe and highly efficacious could be protected from direct contact with the gastrointestinal contents via direct uptake by the cells, boycotting fast metabolism and rapid chemical degradation [8].…”

“…However, curcumin being safe and highly efficacious could be protected from direct contact with the gastrointestinal contents via direct uptake by the cells, boycotting fast metabolism and rapid chemical degradation [8]. Thus, Encapsulation within delivery vehicles to obtain a sustained release and maximum absorption of curcumin at the upper gastrointestinal tract could be achieved since drug delivery system holds a good prospect in oral drug administration [8,9,16].…”