Oral Decontamination of Orthodontic Patients Using Photodynamic Therapy Mediated by Blue-Light Irradiation and Curcumin Associated with Sodium Dodecyl Sulfate

Panhóca, Vitor Hugo; Florez, Fernando Luis Esteban; Corrêa, Thaila Quatrini; Paolillo, Fernanda Rossi; Souza, Clóvis Wesley Oliveira de; Bagnato, Vanderlei Salvador

doi:10.1089/pho.2015.4080

Cited by 48 publications

(27 citation statements)

References 28 publications

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“…A clinical study using the combination of aBL (450 ± 10nm) with curcumin for oral decontamination in orthodontic patients was carried out by Panhoca et al (Panhoca et al, 2016). The result showed that aBL irradiated curcumin significantly reduced the S. mutans survival rate (from 6.33 ± 0.92 to 5.78 ± 0.96 log 10 CFU, P < 0.05).…”

Section: Synergism Of Antimicrobial Blue Light With Other Agentsmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

221

192

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As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

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Section: Synergism Of Antimicrobial Blue Light With Other Agentsmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

221

192

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“…Periodontal diseases have also been treated successfully by aPDI mediated by conventional PS [215–217]. However, de Freitas et al [218] investigated the effect of aPDI using MB-loaded poly(lactic-co-glycolic) (PLGA) NPs (MB-NP) in a clinical pilot study with 10 adult human subjects with chronic periodontitis.…”

Section: Apdi For Treating Localized Infectionsmentioning

confidence: 99%

Advances in antimicrobial photodynamic inactivation at the nanoscale

2017

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The alarming worldwide increase in antibiotic resistance amongst microbial pathogens necessitates a search for new antimicrobial techniques, which will not be affected by, or indeed cause resistance themselves. Light-mediated photoinactivation is one such technique that takes advantage of the whole spectrum of light to destroy a broad spectrum of pathogens. Many of these photoinactivation techniques rely on the participation of a diverse range of nanoparticles and nanostructures that have dimensions very similar to the wavelength of light. Photodynamic inactivation relies on the photochemical production of singlet oxygen from photosensitizing dyes (type II pathway) that can benefit remarkably from formulation in nanoparticle-based drug delivery vehicles. Fullerenes are a closed-cage carbon allotrope nanoparticle with a high absorption coefficient and triplet yield. Their photochemistry is highly dependent on microenvironment, and can be type II in organic solvents and type I (hydroxyl radicals) in a biological milieu. Titanium dioxide nanoparticles act as a large band-gap semiconductor that can carry out photo-induced electron transfer under ultraviolet A light and can also produce reactive oxygen species that kill microbial cells. We discuss some recent studies in which quite remarkable potentiation of microbial killing (up to six logs) can be obtained by the addition of simple inorganic salts such as the non-toxic sodium/potassium iodide, bromide, nitrite, and even the toxic sodium azide. Interesting mechanistic insights were obtained to explain this increased killing.

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Section: Introductionmentioning

confidence: 99%

“…Only two recent reports have studied some of the effects of PDT as oral preventive treatment in patients undergoing orthodontic treatment . These studies concluded that PDT reduces gingival index (GI) scores and Streptococcus mutans load in saliva , which could benefit orthodontically treated patients. It is important therefore to study whether the use of PDT therapy as periodontal maintenance during orthodontic treatment can improve the clinical periodontal parameters by reducing total periodontopathogenic bacteria and so modulate the host immune response and cytokine secretion profile.…”

Section: Introductionmentioning

confidence: 99%

Impact of photodynamic therapy versus ultrasonic scaler on gingival health during treatment with orthodontic fixed appliances

et al. 2018

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Objectives: Poor oral hygiene during treatment with fixed appliances results in plaque accumulation. The presence of bacteria in the gingival crevice triggers an inflammatory reaction in the gingival tissues. The aim of this study was to compare the impact of two preventive treatments, photodynamic therapy (PDT), and ultrasonic scaler (US), on gingival health in patients under fixed orthodontic treatment. Methods: Twenty orthodontic patients were randomly allocated to two groups: PDT or US. Each group received seven sessions [days 0, 15, 30, 45, 90 (3months follow-up), 180 (6-months follow-up), 270 (9months follow-up)] of experimental interventions, and clinical parameters [Plaque index(PI); gingival index-(GI); probing depth(PD)], periodontopathogens [Agreggatibacter actinomycetemcomitans; Porphyromonas gingivalis; Prevotella intermedia; Micromonas micros; Fusobacterium nucleatum; Tannerella forsythia; Campylobacter rectus; Eikenella corrodens; Capnocytopaga sp.] and protein markers [IL-1b;IL-1ra;IL-6;IL-10;TNF-a;FGF-2/FGF basic] were monitored at baseline and at 3, 6, and 9 months. ANOVA, Student's t-test with Bonferroni correction and ANOVA with multiple rank test were used to identify differences between groups (P < 0.05). Results: Clinical assessments [PI, GI, and PD] yielded no differences (P > 0.05) between groups, which showed a major decrease at the start of the trial. Reductions in total colony forming units (log CFU reduction) were observed with both treatments, although to a greater extent in the PDT group, but with no differences between groups (P > 0.05). Similar reductions in log CFU counts of P. gingivalis, P. intermedia, and F. nucleatum were observed in both groups (P > 0.05). The two groups also showed similar trends for inflammatory mediators with decreased levels of IL-1b, IL-10, and TNF-a, whereas IL-6 and IL-1ra levels remained stable and those of FGF-2 were increased after both interventions, with no differences (P > 0.05) between groups. Conclusion: Both PDT and US methods proved similar effectiveness for the treatment of gingival inflammation induced by fixed orthodontic appliances. Lasers Surg. Med. 51:256-267, 2019.

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Oral Decontamination of Orthodontic Patients Using Photodynamic Therapy Mediated by Blue-Light Irradiation and Curcumin Associated with Sodium Dodecyl Sulfate

Abstract: These results indicate that when associated with the surfactant SDS, the aPDT can be used as an adjutant and a convenient agent to promote the oral decontamination in clinical practice.

Cited by 48 publications

References 28 publications

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Advances in antimicrobial photodynamic inactivation at the nanoscale

Impact of photodynamic therapy versus ultrasonic scaler on gingival health during treatment with orthodontic fixed appliances

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