Oral cytology: its value and its limitations

Hayes, Richard L.; Berg, Gordon W.; Ross, William L.

doi:10.14219/jada.archive.1969.0300

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…This is not the case in cytology which can only be of value when a sufficient number of cells are collected in each smear. These cells must be representative of the distinct variations which occur in all layers of the epithelium (Staats & Goldsby 1963, Hayes et al 1969, Blozis 1972, Folsom et al 1972. In this study only 8 smears out of a total of 411 produced an insufficient number of cells for measurement.…”

Section: Resultsmentioning

confidence: 99%

Quantitative Exfoliative Cytology of Normal Oral Squames: An Age, Site and Sex-Related Survey

1985

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Summary: This study describes the development of quantitative cytological techniques and their application to oral smears. Nuclear and cell size has been measured and matched with age, sex and site in an attempt to produce a baseline for comparison with identical measurements carried out on pathological smears. The results displayed a significant variation in nuclear and cytoplasmic area between different sites. Nuclear size varied significantly with advancing age; however, this was not the case for cytoplasmic area. There was no significant variation in either criterion between males and females.

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Section: Resultsmentioning

confidence: 99%

Quantitative Exfoliative Cytology of Normal Oral Squames: An Age, Site and Sex-Related Survey

1985

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“…However, Guinta et al showed, that 2.5% of oral cancers were not correctly diagnosed on the initial biopsy [19], resulting in a sensitivity of only 97.5%. Additionally, there are reports on patients whose initial scalpel biopsies were negative, but whose initial tu- mor cell positive smears subsequently prompted further biopsies that confirmed the presence of carcinomas [22,40]. A potential explanation for the bad sensitivity could be that formerly the obtainment of cells was disadvantageously performed with a cotton tip or scraper.…”

Section: Discussionmentioning

confidence: 99%

Cytologic and DNA‐Cytometric Early Diagnosis of Oral Cancer

Remmerbach

Weidenbach

Pomjanski

et al. 2001

Analytical Cellular Pathology

111

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Objective. The aim of this prospective study was to report on the diagnostic accuracy of conventional oral exfoliative cytology taken from white‐spotted, ulcerated or other suspicious oral lesions in our clinic. In addition we checked DNA‐image cytometry as an adjuvant diagnostic tool. Our hypothesis is that DNA‐aneuploidy is a sensitive and specific marker for the early identification of tumor cells in oral brushings. Study design. 251 cytological diagnoses obtained from exfoliative smears of 181 patients from macroscopically suspicious lesions of the oral mucosa and from clinically seemingly benign oral lesions which were exisiced for establishing histological diagnoses were compared with histological and/or clinical follow‐ups of the respective patients. Additionally nuclear DNA‐contents were measured after Feulgen restaining using a TV image analysis system. Results. Sensitivity of our cytological diagnosis on oral smears for the detection of cancer cells was 94.6%, specificity 99.5%, positive predictive value 98.1% and negative predictive value 98.5%. DNA‐aneuploidy was assumed if abnormal DNA‐stemlines or cells with DNA‐content greater 9c were observed. On this basis the prevalence of DNA‐aneuploidy in smears of oral squamous cell carcinomas in situ or invasive carcinomas was 96.4%. Sensitivity of DNA‐aneuploidy in oral smears for the detection of cancer cells was 96.4%, specificity 100%, positive predictive value 100% and negative 99.0%. The combination of both techniques increased the sensivity to 98.2%, specificity to 100%, positive predictive value to 100% and negative to 99.5%. Conclusions. Brush cytology of all visible oral lesions, if they are clinically considered as suspicious for cancer, are an easily practicable, cheap, non‐invasive, painless, safe and accurate screening method for detection of oral precancerous lesions, carcinoma in situ or invasive squamous cell carcinoma in all stages. We conclude that DNA‐image cytometry is a very sensitive, highly specific and objective adjuvant tool for the early identification of neoplastic epithelial cells in oral smears.

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“…A number of authors have suggested reasons for this including: inadequate sampling, technical error, misinterpretation of the findings and bias5.13.14. [16][17][18]. It is important that techniques are developed to aid in the diagnosis of early oral cancer especially in predicting the behaviour of those lesions which display epithelial dysplasia but no overt malignancy.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Exfoliative Cytology of Abnormal Oral Mucosal Smears

1988

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SummaryIn this study quantitative techniques have been applied to smears collected from the buccal mucosa and floor of the mouth. The results display an encouraging success rate for identifying premalignant and malignant lesions. 'Intrapatient' normal smears provide a satisfactory control for comparison with pathological smears. Early results indicate that quantitative cytology could be of great value for monitoring and follow-up of suspicious lesions and provide an excellent additional diagnostic test for detecting early oral malignancy.

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Oral cytology: its value and its limitations

Cited by 16 publications

References 40 publications

Quantitative Exfoliative Cytology of Normal Oral Squames: An Age, Site and Sex-Related Survey

Quantitative Exfoliative Cytology of Normal Oral Squames: An Age, Site and Sex-Related Survey

Cytologic and DNA‐Cytometric Early Diagnosis of Oral Cancer

Quantitative Exfoliative Cytology of Abnormal Oral Mucosal Smears

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