Oral Crohn′s disease

Padmavathi, BN; Sharma, Smriti; Astekar, Madhusudan; Rajan, Y; Sowmya, G V

doi:10.4103/0973-029x.141369

Cited by 9 publications

(17 citation statements)

References 14 publications

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“…Accordingly, clinical diagnosis of lip leishmaniasis is frequently a challenge with a significantly delayed diagnosis or even an erroneous clinical diagnosis of malignancy [12, 19, 25]. The most important diseases that must be taken into account in differential diagnosis are herpes labialis [26], syphilitic chancre [27], Melkersson-Rosenthal syndrome [28], orofacial granulomatosis [28], cheilitis granulomatosa [29, 30], Wegener granulomatosis [12, 19, 25], oral Crohn’s disease [31], sarcoidosis [32, 33], skin tuberculosis [34], discoid lupus erythematosus [34], lymphoma [34], foreign body giant cell granuloma [12, 19, 25, 28], leprosy [35], mycotic infection [36], fibroma, lipoma, and neuroma [37], basal cell carcinoma [38], and squamous cell carcinoma [34, 39]. The diagnosis is easier to make if typical CL lesions are present elsewhere on the skin.…”

Section: Discussionmentioning

confidence: 99%

Lip leishmaniasis: a case series with molecular identification and literature review

et al. 2017

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BackgroundMucocutaneous leishmaniasis (MCL), a protozoan infectious disease, is very rare in Iran despite the endemicity of both cutaneous and visceral forms. It is transmitted by the Phlebotomus sand fly. The lip is considered one of the extraordinary sites. Lesions usually initiate with erythematous papules, slowly enlarges and then it ulcerates. The diagnosis of MCL encompasses epidemiological, clinical and laboratory aspects. Usually, the combination of some of these elements is necessary for the final diagnosis. So, lip leishmaniasis lesions can be challenging to diagnose.Case presentationWe presented seven rare cases of lip leishmaniasis. Tissue impression smear, culture, PCR and phylogenetic analysis were carried out for explicit diagnosis. Skin scraping investigation showed several Leishmania spp. amastigotes in the cytoplasm of macrophages. Culture examination was positive for Leishmania spp. PCR was positive for L. major, L. tropica, and L. infantum. Differential diagnosis includes orofacial granulomatosis, basal cell carcinoma, squamous cell carcinoma, and mesenchymal tumors. The cases were treated with systemic meglumine antimoniate (Glucantime®). No relapses were observed during 1 year of follow-up. Early detection of the infection are necessary in order to start effective treatment and prevent more serious complications.ConclusionsIn this paper, we reported seven rare cases of lip leishmaniasis in Iran, emphasized the importance of clinical and diagnostic features of lesions, characterized the phylogenetic kinship of isolated parasites, and reviewed the literature on lip leishmaniasis.

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Section: Discussionmentioning

confidence: 99%

Lip leishmaniasis: a case series with molecular identification and literature review

et al. 2017

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“…The oral mucosa is affected by a wide variety of systemic conditions due to the dynamic oral environment and the rapid cell turnover rate [ 2 , 3 ]. When faced with granulomatous lesions of the oral cavity, we should always consider many orofacial granulomatosis (OFG) [ 2 , 3 , 7 , 9 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…In 60% of Crohn's disease patients, oral lesions may be the first sign. Although oral mucosal lesions and symptoms may be more severe during the period of disease flare, the correlation is not universal [ 2 , 7 ]. Specific oral lesions are characterized by the presence of noncaseating granuloma at the histopathology analysis.…”

Section: Introductionmentioning

confidence: 99%

“…Management principles are similar to those with typical Crohn's disease, starting with topical therapy and progressing to systemic therapy such as glucocorticoids, 5-aminosalicylic acid, immunomodulators and biologics, like anti-tumor necrosis factor (TNF) antibodies [ 2 , 3 , 6 , 7 , 9 , 12 ]. The use of anti-TNF-α (infliximab in particular) has been suggested to have a role in the management of OCD and orofacial granulomatosis (OFG) in a number of case reports and case series [ 9 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Rare Oral Crohn’s Disease: A Case Report

Veiga¹,

Leite²,

Ferrão³

et al. 2023

Cureus

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Crohn's disease is an inflammatory granulomatous and chronic disease characterized by inflammation of the gastrointestinal mucosa with extra-intestinal manifestations. Oral lesions seem to occur as specific lesions like lip swelling, cobblestone or tag lesions, or nonspecific lesions like ulcers. The present case report describes an orofacial Crohn’s disease case, a rare presentation of Crohn’s disease, managed with infliximab. Oral Crohn's disease refers to the spread of manifestations of Crohn’s disease and could precede other signs. Physicians have to be aware of oral mucosal changes. The treatment options are based on the use of corticosteroids, immune-modulators and biologics. The best plan and therapy to control oral Crohn's disease requires early and precise diagnosis.

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“…Crohn's disease (CD) and Ulcerative colitis (UC) manifest in different ways. CD is typically characterized by granulomatous inflammation that can affect any part of the gastrointestinal tract (GIT) and involve all mucosal layers, while the inflammation in UC is limited to the colon and only affects the mucosa and superficial submucosa ( 42 – 44 ). The variability in location and the transmural nature of CD leads to a wide variety of presentations and in severe cases, patients may present with systemic symptoms, including fever, anorexia, and weight loss ( 45 , 46 ).…”

Section: Oral and Gut Manifestations Of Ibdmentioning

confidence: 99%

The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers?

2021

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The oral cavity is continuous with the gastrointestinal tract and in children, oral health may be closely linked with the overall health of the GI tract. In the case of pediatric Crohn's disease (CD), oral manifestations are an important clinical indicator of intestinal disease. Recent studies of the microbiome in IBD suggest that translocation of oral microbes to the gut may be a common feature of the microbial dysbiosis which is a signature of both CD and ulcerative colitis (UC). Murine studies suggest that translocation of oral bacteria and yeasts to the lower GI tract may trigger inflammation in susceptible hosts, providing a mechanistic link to the development of IBD. Conversely, some studies have shown that dysbiosis of the oral microbiome may occur, possibly as a result of inflammatory responses and could represent a useful source of biomarkers of GI health. This review summarizes our current knowledge of the oral microbiome in IBD and presents current hypotheses on the potential role of this community in the pathogenesis of these diseases.

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Oral Crohn′s disease

Cited by 9 publications

References 14 publications

Lip leishmaniasis: a case series with molecular identification and literature review

Lip leishmaniasis: a case series with molecular identification and literature review

Rare Oral Crohn’s Disease: A Case Report

The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers?

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