Oral cortisone therapy in allergic diseases

Friedlaender, Sidney; Friedlaender, Alex S.

doi:10.1016/0021-8707(51)90030-5

Cited by 15 publications

(3 citation statements)

References 8 publications

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“…With eosinophil blood counts, balances of chloride, sodium, sugar, potassium, and nitrogen, and study of 17ketosteroids they could find no such correlation, and it has been suggested from the findings that in asthma the beneficial effect may depend upon some special function of the hormone. The lack of any definite correlation between clinical response and the eosinophil count has been confirmed by Friedlaender and Friedlaender (1951a) and by Feinberg et al (1951).…”

Section: Discussionmentioning

confidence: 89%

“…we have a potent substance in the treatment of asthma. Friedlaender and Friedlaender (1951b) gave it to 10 severe chronic asthmatics in a dosage of 52 mg. six-hourly, intramuscularly, with total dosage of 600-870 mg. in 6-13 days They found dramatic improvement in six patients within 24-36 hours, fair response in two, and no real improvement in two. They pointed out that the relief was of brief duration before recurrence, and that seasonal hypersensitive cases should therefore give the most satisfactory results.…”

Section: Discussionmentioning

confidence: 99%

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The Treatment of Asthma with Corticotrophin

Pearson¹

1955

BMJ

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

The Treatment of Asthma with Corticotrophin

Pearson¹

1955

BMJ

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“…Parish (1959) found dexamethasone produced marked relief of symptoms in 27 of 30 cases of bronchial asthma, allergic rhinitis or allergic dermatoses, and concluded that it was 6 times as potent as prednisolone and ~O times as potent as hydrocortisone. Fried• laencler and Friedlaender (1959) obtained ~ good response in 123 of 171 allergic con? 1 • tions treated, 55 of 75 patients with bronchial asthma giving a good response.…”

Section: Chemistrymentioning

confidence: 99%

Dexamethasone: Its Place in Therapeutics: A Review of Recent Literature

Hart

1960

Int J Clinical Practice

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CORTISONE, the first of the adrenocortical steroids with glucocorticoid and mineralocorticoid actions, was demonstrated in 1949 by Hench and his colleagues as being of use in the treatment of rheumatoid arthritis. Very soon its therapeutic horizon was widely extended to cover a large number of other conditions, mostly endocrinological or inflammatory. After this, hydrocortisone (cortisol) appeared, then prednisolone and prednisone, triamcinolone, methyl prednisolone and, finally, dexamethasone. Each was brought out in the hope that side (unwanted) effects would be less while clinical (wanted) effects would be more, and claims were made for each in turn which later work failed to confirm in all instances. All compounds produced since hydrocortisone had demonstrably less sodiumretaining effect: triamcinolone differed from the others in producing a certain number of side-effects not common with its predecessors, anorexia instead of the usual tonic effect on the appetite, post-prandial flushing, giddiness and, the most important, myasthenia. Ten years after the original cortisone was produced from the laboratories of Merck & Co. in New Jersey, their new substance appeared, dexamethasone (Decadron, Merck Sharp & Doh me). The claims were that this new substance was far more potent than any of its predecessors and that it (once again, almost, one might say, inevitably) produced fewer "side" effects.One point should be emphasized here. These so-called side effects are very much intrinsic, built-in properties of the drug. Cortisone, a hormone, when given in pharmacological doses to patients with intact adrenal glands, produces, inevitably, some of the features of Cushing's disease: striae, acne, ecchymoses, moon face, overgrowth of fluffy, fine hair, osteoporosis and, occasionally, fractures, mental upsets, peptic u,Jceration, glycosuria and hyperglycaemia. So, in fact, do all

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Natural Steroid Complex ("Marisone") in Treatment of Cutaneous Diseases

Spielman¹,

Blau²

1952

Arch Dermatol

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Oral cortisone therapy in allergic diseases

Cited by 15 publications

References 8 publications

The Treatment of Asthma with Corticotrophin

The Treatment of Asthma with Corticotrophin

Dexamethasone: Its Place in Therapeutics: A Review of Recent Literature

Natural Steroid Complex ("Marisone") in Treatment of Cutaneous Diseases

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