Oral Controlled-Release Delivery of Ivermectin in Cattle via an Osmotic Pump

Llamas and alpacas in Europe: Endoparasites of the digestive tract and their pharmacotherapeutic control

“…Oral administration (0.2 mg/kg BW) did not lead to detectable plasma levels (Jarvinen et al, 2002). This finding is in agreement with the data obtained in cattle, sheep and horses showing a lower bioavailability of ivermectin after oral dosing than after SC administration (Pope et al, 1985;Marriner et al, 1987;Bogan and McKellar, 1988;Chiu et al, 1990). It was suggested that ivermectin binds to ingesta and that this influences the systemic availability of ivermectin after oral administration, however, ATPbinding cassette (ABC)-transporters in the gut might well account for reduced bioavailability.…”

Use of Ivermectin in Cattle, Sheep, Goats, and Swine

“…Initial trials utilizing an osmotic pump to deliver ivermectin at steady-state rate (Pope et al 1985) over 28 days demonstrated that prophylaxis against newly ingested larvae (Egerton, Suhayda, and Eary 1986), as well as therapy against established infections could be accomplished with a dose of 40 JLg/kg/day (Baggott, Batty, and Ross 1986). The same dose prevented the engorgement by adult female multihost ticks (Soil, Carmichael, and Gross 1987).…”

Effects of Gastrointestinal Helminth Parasites on Ruminant Nutrition

“…Systems to control infection include medication of feed or drinking water (Downey et al 1974;Jones et al 1978) and intraruminal devices for cattle providing either pulsed or continuous medication with anthelmintics such as morantel tartrate (Armour et al 1981 ;Jones 1981 ; Borgsteede et al 1985), oxfenbendazole (Morgan & Rowlands, 1986;Jacobs et al 1987;Mitchell, 1987) and ivermectin (Pope et al 1985;Egerton et al 1986;Sol1 et al 1988).…”