Oral controlled and sustained drug delivery systems

Kaur, Gaganjot; Grewal, Jasleen; Jyoti, Kiran; Jain, Upendra Kumar; Chandra, Ramesh; Madan, Jitender

doi:10.1016/b978-0-12-813689-8.00015-x

Cited by 80 publications

(43 citation statements)

References 133 publications

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“…The water solubility of these polymers is pH dependent, which allows pH-dependent drug release (da Silva et al, 2017). The biggest advantage of Eudragit L100 is that it protects the drug from the acidic environment of the stomach, and allows controlled release in the intestine and colon (Kaur et al, 2018).…”

Section: Synthetic Polymersmentioning

confidence: 99%

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Stojanov

Berlec

2020

Front. Bioeng. Biotechnol.

124

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Electrospinning is a technique that uses polymer solutions and strong electric fields to produce nano-sized fibers that have wide-ranging applications. We present here an overview of the use of electrospinning to incorporate biological products into nanofibers, including microorganisms, cells, proteins, and nucleic acids. Although the conditions used during electrospinning limit the already problematic viability/stability of such biological products, their effective incorporation into nanofibers has been shown to be feasible. Synthetic polymers have been more frequently applied to make nanofibers than natural polymers. Polymer blends are commonly used to achieve favorable physical properties of nanofibers. The majority of nanofibers that contain biological product have been designed for therapeutic applications. The incorporation of these biological products into nanofibers can promote their stability or viability, and also allow their delivery to a desired tissue or organ. Other applications include plant protection in agriculture, fermentation in the food industry, biocatalytic environmental remediation, and biosensing. Live cells that have been incorporated into nanofibers include bacteria and fungi. Nanofibers have served as scaffolds for stem cells seeded on a surface, to enable their delivery and application in tissue regeneration and wound healing. Viruses incorporated into nanofibers have been used in gene delivery, as well as in therapies against bacterial infections and cancers. Proteins (hormones, growth factors, and enzymes) and nucleic acids (DNA and RNA) have been incorporated into nanofibers, mainly to treat diseases and enhance their stability. To summarize, incorporation of biological products into nanofibers has numerous advantages, such as providing protection and facilitating controlled delivery from a solid form with a large surface area. Future studies should address the challenge of transferring nanofibers with biological products into practical and industrial use.

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Section: Synthetic Polymersmentioning

confidence: 99%

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Stojanov

Berlec

2020

Front. Bioeng. Biotechnol.

124

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“…There are different ways of drug delivery. Orally [2], localized, magnetic or transdermal [3][4][5]. The controlled release of drugs is conditioned by certain aspects to increase the effectiveness of the therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Polymeric delivery agents are becoming increasingly important because of the several possibilities they offer. The permeability of the polymer matrix, glass transition temperature, viscosity, degradation, and polymer concentration represent the effective parameters that regulate the release of the drug through the matrix [2]. Hydrophilic polymers are good candidates here because they are provided with pores facilitating the release of the drug, particularly in the case of poorly soluble drugs.…”

Section: Introductionmentioning

confidence: 99%

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Abbasnezhad

Shirinbayan

Tcharkhtchi

et al. 2020

Journal of Drug Delivery Science and Technology

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Drug-eluting implants with a polymeric matrix are currently widely used and the interest of modeling their behavior is increasing. This article aims to present preliminary results of an in vitro under steady flow, study the behavior of drug-loaded polyurethane samples used as drug delivery matrices. Polyisocyanate and polyol synthesis supplied the polyurethane studied in this work. A molding and heat at 50°C for about 30 min make it possible to prepare films from these components. The prepared samples are placed in the impermeable Plexiglas tube and they are in contact with the medium (distilled water). Tests have been performed without flow and three other cases with steady flow, at a temperature of 37°C. The substance active incorporated in these films, as the drug, for carrying out the release tests is the C 20 H 24 C 12 N 2 O 3. This drug supplied in granular form is composed of a mixture in the following proportions, 15 mg of diclofenac epolamine and 50 mg of diclofenac-sodium. Four sample variants were carefully prepared: pure-PU and PU loaded in a mass ratio of 10, 20 or 30%. Weighing, DSC, FT-IR, and DMTA are the methods used to analyze the samples. In addition, SEM micrographs are used to explore qualitatively the microstructure during the release tests. The kinetics in vitro of the drug release and water absorption by the polyurethane films are discussed in detail. The results show that these two quantities depend on the initial drug loading and the flow rate value, as a function of the in vitro incubation time.

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“…Oral sustained release products provide several lucrative advantages over conventional dosage forms by maximizing the pharmacokinetic and pharmacodynamic traits of drugs. Sustained release dosage forms provide temporal and spatial control over drug release which cannot be achieved by conventional or immediate release dosage forms [12].…”

Section: Introductionmentioning

confidence: 99%

Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Öztürk¹,

Aygül²

2020

jrp

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Spray drying is an important method used in pharmaceutical product manufacturing for many years. The nano-spray dryer developed in recent years provides ultrafine powders at nanoscale and high product yields. In this study, which was aimed at prolonged release in oral use, nanoparticles-(NPs) were obtained by nanoenglobation of cefaclor monohydrate-(CEF) with Eudragit RS 100-(ERS) with the help of nano-spray drying method. The particle size (PS) of the blank formulation was 186 nm whereas PSs of CEF containing NPs were between 328 and 389 nm. The average PDI of all NP formulations were below 0.4 and all prepared NPs had a positive ZP value. The encapsulation efficiency values were a range of 78-84 %. In vitro release studies of NPs showed extended-release up to 24 hours after the first 3 hours of burst effect. The results showed that the release kinetics were fitted to the Korsmeyer-Peppas model. As a result, it was found that all pharmaceutical technology analysis results were affected by the solid concentration ratio in the feed dispersion. Antibacterial activity of NP formulations was determined by microdilution method. After minimum inhibitory concentration (MIC) determination, time-dependent activity for NP-2 was investigated by the time-kill method. MIC value for NP-2 was 4-fold lower than MIC value of CEF for Staphylococcus aureus and Escherichia coli. No growth was observed for both bacteria with NP-2 during 18 hours incubation in the time-kill method. As a result, prolonged antibiotic release and long-term antibacterial activity were obtained by NP-2, the optimum formulation of our study.

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Oral controlled and sustained drug delivery systems

Cited by 80 publications

References 133 publications

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

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