Oral contraceptive effectiveness according to body mass index, weight, age, and other factors

Currently available combined oral contraception

“…The only exception to this was a significant association of contraceptive failure in chlormadinone acetate-containing COC, which is highly lipophilic, among women with a high BMI (≥30 kg/m 2 ; p = 0.028) [73]. The average BMI of women enrolled in the EURAS-OC study was 22.1 ± 4.1 kg/m 2 compared with 26.3 ± 7.3 kg/m 2 in the US arm of the INAS-OC study [72,73]. Importantly, the US cohort of the INAS-OC study included a higher percentage of women in the WHO obesity classifications II and III (BMI: 35 kg/m 2 or more) [72].…”

“…There was also little variation in contraceptive failure, stratified by BMI and progesterone type for desogestrel, dienogest, drospirenone and levonorgestrel [73]. The only exception to this was a significant association of contraceptive failure in chlormadinone acetate-containing COC, which is highly lipophilic, among women with a high BMI (≥30 kg/m 2 ; p = 0.028) [73]. The average BMI of women enrolled in the EURAS-OC study was 22.1 ± 4.1 kg/m 2 compared with 26.3 ± 7.3 kg/m 2 in the US arm of the INAS-OC study [72,73].…”

“…The EURAS-OC study found no effect of BMI and weight on overall contraceptive efficacy [73]. There was also little variation in contraceptive failure, stratified by BMI and progesterone type for desogestrel, dienogest, drospirenone and levonorgestrel [73]. The only exception to this was a significant association of contraceptive failure in chlormadinone acetate-containing COC, which is highly lipophilic, among women with a high BMI (≥30 kg/m 2 ; p = 0.028) [73].…”

“…The EURAS-OC study found no effect of BMI and weight on overall contraceptive efficacy [73]. There was also little variation in contraceptive failure, stratified by BMI and progesterone type for desogestrel, dienogest, drospirenone and levonorgestrel [73].…”

“…Study on Oral Contraceptives (EURAS-OC), which followed over 100,000 women every 6 months for up to 5 years taking oral contraceptives from 2000-2008 [72,73]. The EURAS-OC study found no effect of BMI and weight on overall contraceptive efficacy [73].…”