Oral contraceptive and IUD use and endometrial cancer: A population‐based case–control study in Shanghai, China

Abstract

Oral contraceptive (OC) and intrauterine device (IUD) use have been shown to be protective factors for endometrial cancer in several epidemiological studies; however, few studies have been conducted in Chinese populations. We evaluated the association between OC and IUD use and endometrial cancer risk in a population-based case-control study among Chinese women in Shanghai, China. The study included 1,204 newly diagnosed endometrial cancer cases and 1,212 age frequency-matched healthy controls. Logistic regression models were used to estimate adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). In our study population, 18.5% cases and 24.9% controls reported having ever used OCs with an OR of 0.75 (95% CI, 0.60-0.93), after adjusting for known risk or protective factors for endometrial cancer. The risk of endometrial cancer decreased with long-term use of OCs with the OR for more than 72 months of use being 0.50 (95% CI, 0.30-0.85). The effect of OC use remained 25 or more years after cessation of use; the associated OR was 0.57 (95% CI 5 0.42-0.78) as compared to nonusers. Similarly, fewer cases than controls had ever used IUD, with the multivariable adjusted OR being 0.53 (95% CI 5 0.43-0.65). A reduction in risk was observed regardless the duration of use or age at first and last use. These results suggest that OC and IUD use may confer long-term protection against endometrial cancer. ' 2006 Wiley-Liss, Inc.

Hormonal contraception and risk of endometrial cancer: a systematic review

“…Similar trends were also observed in a large recent Chinese case-control study (Tao et al 2006;nZ1.204/1.212). The risk for ever users of COC was decreased (OR 0.75; 95% CI 0.60-0.93), the protective effect increased with duration of use (5 years or more: OR 0.50; 95% CI 0.30-0.85) and remained for 25 years Levi et al 1991, Stanford et al 1993.…”

Cytochrome P450 1B1 and Catechol-O-Methyltransferase Genetic Polymorphisms and Endometrial Cancer Risk in Chinese Women

“…The distributions of selected demographic characteristics and major risk factors of endometrial cancer among cases and controls have been reported elsewhere (10). Briefly, cases and controls had similar age distribution.…”

“…Detailed study methods have been published previously (10). In brief, this study includes 1,204 incident cases who were between 30 and 69 years of age at diagnosis and 1,212 randomly selected, age-frequency matched population controls.…”

Cost‐effectiveness analysis of prevention strategies for gynecologic cancers in Lynch syndrome

“…To our knowledge, there are no other data available concerning other nonsurgical strategies to reduce gynecologic cancer risks in this population, such as oral contraceptives (OCPs) or progestin intrauterine devices. OCPs decrease endometrial and ovarian cancer risks in the general population by approximately 50%, [34][35][36][37][38][39][40][41][42][43] and progestin intrauterine devices may reverse hyperplasia and early endometrial cancer. 44,45 Because Lynch syndrome-associated gynecologic cancers appear to be similar to sporadic cases, 4,46 these chemoprevention strategies may be beneficial with less adverse effect on quality of life than prophylactic surgery.…”